scholarly journals Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1α expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells

2014 ◽  
Vol 7 (5) ◽  
pp. 1401-1408 ◽  
Author(s):  
JING ZHANG ◽  
HUA GUO ◽  
JIN-SHUI ZHU ◽  
YU-CHEN YANG ◽  
WEI-XIONG CHEN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Hypoxia Inducible Factor ◽  
Akt Pathway ◽  
Gastric Cancer Cells ◽  
Hypoxia Inducible Factor 1Α ◽  
Phosphoinositide 3 Kinase

scholarly journals Hypoxia regulates CD44 expression via hypoxia-inducible factor-1α in human gastric cancer cells

2016 ◽  
Vol 13 (2) ◽  
pp. 967-972 ◽  
Author(s):  
Gai Liang ◽  
Shuang Li ◽  
Wei Du ◽  
Qinghua Ke ◽  
Jun Cai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Cd44 Expression ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1α

2012 ◽  
Vol 28 (6) ◽  
pp. 2239-2246 ◽  
Author(s):  
YOON SUK OH ◽  
HA YON KIM ◽  
IK-CHAN SONG ◽  
HWAN-JUNG YUN ◽  
DEOG-YEON JO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Biological Activity ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Cxcr4 Expression ◽  
Gastric Cancer Cells ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Down-regulation of HIF-1α inhibits the proliferation, migration, and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Jingjing Zhang ◽  
Jun Xu ◽  
Yonghong Dong ◽  
Bo Huang
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Akt Pathway ◽  
Migration And Invasion ◽  
Vegf Expression ◽  
Gastric Cancer Cells ◽  
Tumor Tissues ◽  
Sirna Silencing ◽  
Gastric Cancer Patients

In view of the high incidence of gastric cancer and the functions of hypoxia-inducible factor 1α (HIF-1α), our study aimed to investigate the functionality of HIF-1α in gastric cancer, and to explore the diagnostic and prognostic values of HIF-1α for this disease. Expression of HIF-1α in tumor tissues and adjacent healthy tissues as well as serum collected from both gastric cancer patients and normal healthy controls was detected by qRT-PCR. Survival analysis was performed using Kaplan–Meier method. HIF-1α siRNA silencing cell lines were established. Effects of HIF-1α siRNA silencing as well as PI3K activator sc3036 on proliferation, migration, and invasion of gastric cancer cells were detected by Cell counting kit (CCK-8) assay, and Transwell migration and invasion assay. Effects of HIF-1α siRNA silencing on AKT and VEGF were detected by Western blot. Expression of HIF-1α was significantly down-regulated in tumor tissues than in adjacent healthy tissues in most gastric cancer patients. Serum levels of HIF-1α were also higher in gastric cancer patients than in normal healthy people. Serum HIF-1α showed promising diagnostic and prognostic values for gastric cancer. HIF-1α siRNA silencing inhibited the proliferation, migration, and invasion of gastric cancer cells, while PI3K activator sc3036 treatment reduced those inhibitory effects. Down-regulation of HIF-1α can inhibit the proliferation, migration, and invasion of gastric cancer possibly by inhibiting PI3K/AKT pathway and VEGF expression.

scholarly journals miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells

2013 ◽  
Vol 45 (11) ◽  
pp. 963-972 ◽  
Author(s):  
Y. Fang ◽  
H. Shen ◽  
H. Li ◽  
Y. Cao ◽  
R. Qin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Akt Pathway ◽  
Gastric Cancer Cells
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