scholarly journals RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells

Oncogene ◽  
2013 ◽  
Vol 33 (11) ◽  
pp. 1458-1467 ◽  
Author(s):  
S H Lee ◽  
S C Bae ◽  
K W Kim ◽  
Y M Lee
Keyword(s):  
Gastric Cancer ◽  
Protein Stability ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Gastric Cancer Cells ◽  
Prolyl Hydroxylases ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Hypoxia regulates CD44 expression via hypoxia-inducible factor-1α in human gastric cancer cells

2016 ◽  
Vol 13 (2) ◽  
pp. 967-972 ◽  
Author(s):  
Gai Liang ◽  
Shuang Li ◽  
Wei Du ◽  
Qinghua Ke ◽  
Jun Cai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Cd44 Expression ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1α

2012 ◽  
Vol 28 (6) ◽  
pp. 2239-2246 ◽  
Author(s):  
YOON SUK OH ◽  
HA YON KIM ◽  
IK-CHAN SONG ◽  
HWAN-JUNG YUN ◽  
DEOG-YEON JO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Biological Activity ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Cxcr4 Expression ◽  
Gastric Cancer Cells ◽  
Hypoxia Inducible Factor 1Α

scholarly journals HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability

2013 ◽  
Vol 456 (2) ◽  
pp. 195-204 ◽  
Author(s):  
I-Ju Yeh ◽  
Ndiya Ogba ◽  
Heather Bensigner ◽  
Scott M. Welford ◽  
Monica M. Montano
Keyword(s):  
Protein Stability ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Post Translational Modifications ◽  
Hypoxia Inducible Factor 1Α ◽  
Direct Target ◽  
Inducible Protein ◽  
Insight Into

Our studies provide new insight into the inhibition of HIF-1α (hypoxia-inducible factor 1α). We report that HIF-1α is a direct target of HEXIM1 (hexamethylene-bis-acetamide-inducible protein-1) and that HEXIM1 modulates post-translational modifications of HIF-1α. Thus HEXIM1 is a critical regulator of HIF-1α activities in cancer cells.

DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells

2015 ◽  
Vol 469 (3) ◽  
pp. 469-480 ◽  
Author(s):  
Shanshan Qiao ◽  
Weiwei Guo ◽  
Lujian Liao ◽  
Lin Wang ◽  
Zheng Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Stability ◽  
Cancer Cells ◽  
Tumour Suppressor ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

The protein stability and polyubiquitination of PAQR3, a tumour suppressor, are modulated by DDB2. The proliferation and migration of gastric cancer cells are altered by DDB2. Therefore DDB2 functions as a post-translational regulator of PAQR3 and modulates tumorigenesis.

Alpha-fetoprotein producing gastric cancer cells lack transcription factor AT-motif binding factor 1 (ATBF1)

2001 ◽  
Vol 120 (5) ◽  
pp. A31-A31
Author(s):  
H KATAOKA ◽  
T JOH ◽  
T OHSHIMA ◽  
Y ITOH ◽  
K SENOO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Alpha Fetoprotein ◽  
Gastric Cancer Cells ◽  
Binding Factor
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