scholarly journals miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells

2013 ◽  
Vol 45 (11) ◽  
pp. 963-972 ◽  
Author(s):  
Y. Fang ◽  
H. Shen ◽  
H. Li ◽  
Y. Cao ◽  
R. Qin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Akt Pathway ◽  
Gastric Cancer Cells

miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN

Toxicology ◽  
2013 ◽  
Vol 306 ◽  
pp. 162-168 ◽  
Author(s):  
Shou-mei Yang ◽  
Cheng Huang ◽  
Xiao-feng Li ◽  
Ming-zhe Yu ◽  
Yong He ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Gastric Cancer Cells

scholarly journals Down-regulation of HIF-1α inhibits the proliferation, migration, and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Jingjing Zhang ◽  
Jun Xu ◽  
Yonghong Dong ◽  
Bo Huang
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Akt Pathway ◽  
Migration And Invasion ◽  
Vegf Expression ◽  
Gastric Cancer Cells ◽  
Tumor Tissues ◽  
Sirna Silencing ◽  
Gastric Cancer Patients

In view of the high incidence of gastric cancer and the functions of hypoxia-inducible factor 1α (HIF-1α), our study aimed to investigate the functionality of HIF-1α in gastric cancer, and to explore the diagnostic and prognostic values of HIF-1α for this disease. Expression of HIF-1α in tumor tissues and adjacent healthy tissues as well as serum collected from both gastric cancer patients and normal healthy controls was detected by qRT-PCR. Survival analysis was performed using Kaplan–Meier method. HIF-1α siRNA silencing cell lines were established. Effects of HIF-1α siRNA silencing as well as PI3K activator sc3036 on proliferation, migration, and invasion of gastric cancer cells were detected by Cell counting kit (CCK-8) assay, and Transwell migration and invasion assay. Effects of HIF-1α siRNA silencing on AKT and VEGF were detected by Western blot. Expression of HIF-1α was significantly down-regulated in tumor tissues than in adjacent healthy tissues in most gastric cancer patients. Serum levels of HIF-1α were also higher in gastric cancer patients than in normal healthy people. Serum HIF-1α showed promising diagnostic and prognostic values for gastric cancer. HIF-1α siRNA silencing inhibited the proliferation, migration, and invasion of gastric cancer cells, while PI3K activator sc3036 treatment reduced those inhibitory effects. Down-regulation of HIF-1α can inhibit the proliferation, migration, and invasion of gastric cancer possibly by inhibiting PI3K/AKT pathway and VEGF expression.

scholarly journals RNF138 confers cisplatin resistance in gastric cancer cells via activating Chk1 signaling pathway

2018 ◽  
Vol 19 (12) ◽  
pp. 1128-1138 ◽  
Author(s):  
Yalan Lu ◽  
Deqiang Han ◽  
Wenjie Liu ◽  
Rong Huang ◽  
Jinhuan Ou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cisplatin Resistance ◽  
Gastric Cancer Cells

scholarly journals MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1

2016 ◽  
Vol 12 (12) ◽  
pp. 1437-1447 ◽  
Author(s):  
Yajie Zhang ◽  
Wenxia Xu ◽  
Pan Ni ◽  
Aiping Li ◽  
Jianwei Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals MCM3AP‑AS1 promotes cisplatin resistance in gastric cancer cells via the miR‑138/FOXC1 axis

2021 ◽  
Vol 21 (3) ◽  
Author(s):  
Han Sun ◽  
Ping Wu ◽  
Bao Zhang ◽  
Xia Wu ◽  
Weixu Chen
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Gastric Cancer Cells
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