scholarly journals The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1 gene in patients with bronchial asthma

2012 ◽  
Author(s):  
Janusz Szemraj
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Bronchial Asthma ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals ASSOCIATION OF IL5, CCL26 AND CCL5 GENE POLYMORPHISMSWITH ATOPIC BRONCHIAL ASTHMA

2010 ◽  
Vol 7 (6) ◽  
pp. 20-24
Author(s):  
O E Voronko ◽  
E V Dmitrieva-Zdorova ◽  
E A Latysheva ◽  
M G Aksenova ◽  
G I Storozhakov ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Single Nucleotide Polymorphisms ◽  
Bronchial Asthma ◽  
Asthma Severity ◽  
Moscow Region ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Atopic Bronchial Asthma ◽  
Healthy Donors

The purpose of the work. In order to investigate whether single nucleotide polymorphisms С(-703)Т in IL5 gene, T(+2497)G in CCL26 and A(-403)G in CCL5 gene contribute to atopic bronchial asthma development we performed a comparative analysis of alleles and genotypes frequencies of these polymorphisms in Russian patients from Moscow region. Materials and methods. DNA samples from 283 patients with atopic bronchial asthma and 227 healthy donors were genotyped. Results. There were associations neither of С(-703)Т in IL5 gene, T(+2497)G in CCL26 and A(-403)G in CCL5 gene with asthma nor with asthma severity. Conclusion. Therefore, we may conclude that genes responsible for activation and chemotaxis of eosinophils play an insignificant role in susceptibility to development of atopic bronchial asthma, and probably may influence indirectly specific processes that occur in asthma.-

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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