scholarly journals THE DIFFERENT RELATIONSHIP IN SINGLE NUCLEOTIDE POLYMORPHISMS OF CHITINASE 3-LIKE 1 (CHI3L1) GENE, CHI3L1 SERUM LEVEL, WITH BRONCHIAL ASTHMA AND ALLERGIC RHINITIS IN TAIWAN

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 218-218
Keyword(s):  
Allergic Rhinitis ◽  
Serum Level ◽  
Single Nucleotide Polymorphisms ◽  
Bronchial Asthma ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis

2014 ◽  
Vol 78 (9) ◽  
pp. 1426-1429 ◽  
Author(s):  
Rasoul Nasiri ◽  
Masoud Movahedi ◽  
Ali Akbar Amirzargar ◽  
Armin Hirbod-Mobarakeh ◽  
Elham Farhadi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Single Nucleotide Polymorphisms ◽  
Interleukin 6 ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis

2009 ◽  
Vol 129 (2) ◽  
pp. 190-194 ◽  
Author(s):  
Luo Zhang ◽  
Luo Zhang ◽  
Xiangdong Wang ◽  
Demin Han ◽  
Hong Duan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis

2006 ◽  
Vol 51 (4) ◽  
pp. 292-297 ◽  
Author(s):  
Chun-Shi Li ◽  
Soo-Cheon Chae ◽  
Jae-Hoon Lee ◽  
Qinggao Zhang ◽  
Hun-Taeg Chung
Keyword(s):  
Allergic Rhinitis ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals HIF-1α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions

2021 ◽  
Vol 12 ◽  
Author(s):  
Jelte Kelchtermans ◽  
Xiao Chang ◽  
Michael E. March ◽  
Frank Mentch ◽  
Patrick M. A. Sleiman ◽  
...  
Keyword(s):  
Experimental Data ◽  
Allergic Rhinitis ◽  
Single Nucleotide Polymorphisms ◽  
Association Study ◽  
Acute Bronchitis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Disease Associations

Despite experimental data linking HIF-1α dysfunction to inflammatory airway conditions, the effect of single nucleotide polymorphisms within the HIF1A gene on these conditions remains poorly understood. In the current study, we complete a phenotype wide association study to assess the link between SNPs with known disease associations and respiratory phenotypes. We report two SNPs of the HIF1A gene, the intronic rs79865957 and the missense rs41508050. In these positions the A and the T allele are significantly associated with allergic rhinitis and acute bronchitis and bronchiolitis, respectively. These findings further support the role of HIF-1α in inflammatory pulmonary conditions and may serve as a basis to refine our understanding of other HIF-1α associated phenotypes.

scholarly journals Serum level and single-nucleotide polymorphisms of toll-like receptor-7 among urinary bladder cancer Iraqi patients

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Rasha M. A. Al-Humairi ◽  
Muna T. Al-Musawi ◽  
Ali H. Ad’hiah
Keyword(s):  
Bladder Cancer ◽  
Serum Level ◽  
Urinary Bladder ◽  
Single Nucleotide Polymorphisms ◽  
Mitomycin C ◽  
Urinary Bladder Cancer ◽  
Nucleotide Polymorphisms ◽  
Bacillus Calmette Guerin ◽  
Toll Like Receptor ◽  
Single Nucleotide

Abstract Background Toll-like receptor 7 (TLR7), a member of TLR family, plays a pivotal role in pathogenesis of different malignancies. Among these is urinary bladder cancer (UBC), which has not been extensively studied. Therefore, it was aimed to determine TLR7 serum level in UBC patients and evaluate its association with some demographic and clinicopathological characteristics. In addition, four TLR7 single-nucleotide polymorphisms (SNPs: rs179018, rs179019, rs179020, and rs179021) were investigated to determine their susceptibility role in UBC and inspect SNP’s impact on TLR7 level. Sixty-six UBC Iraqi patients were enrolled in this case-control study. Two control samples were also involved, 40 urinary tract infection (UTI) patients, and 48 healthy control subjects. Results Male gender, older age, and cigarette-smoking are risk factors for UBC. TLR7 level showed a significant decreased median in UBC patients compared to UTI patients or control (1.4 vs. 8.1 and 9.5 ng/ml, respectively; p < 0.001). The decrease was more pronounced in males, age group ≥ 48 years, cigarette-smokers, alcohol non-consumers, clinical stages I–II, and superficial tumor, as well as patients with family history of cancer and untreated patients. Mitomycin C and Bacillus Calmette–Guérin therapies tended to increase TLR7 level. Among the four investigated SNPs, only rs179019 C allele showed significantly uncorrected increased frequency in UBC males compared to control males (p = 0.038), while among UTI females, C allele frequency maintained a significantly corrected decreased frequency compared to control females (p = 0.005). Some SNPs influenced serum level of TLR7, but a significant impact was recorded for rs179019 in UTI females (p = 0.006). Conclusions Downregulation of TLR7 is suggested to have a role in etiology and pathogenesis of UBC, especially the male, elderly and smoker patients. Mitomycin C and Bacillus Calmette–Guérin may enhance TLR7 production in the blood of UBC patients. TLR7 SNPs are suggested to influence susceptibility to develop UBC, and their potential in impacting TLR7 serum level is augmented.

scholarly journals Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome

2019 ◽  
Author(s):  
Fatemeh Hesampour ◽  
Bahia Namavar Jahromi ◽  
Foroozan Tahmasebi ◽  
Behrouz Gharesi-Fard
Keyword(s):  
Serum Level ◽  
Single Nucleotide Polymorphisms ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Nucleotide Polymorphisms ◽  
Iranian Women ◽  
Ovary Syndrome ◽  
Single Nucleotide ◽  
Interleukin 17A

Polycystic ovary syndrome (PCOS) is correlated with low-grade chronic inflammation. Interleukin-17A (IL-17A) and Interleukin-32 (IL-32) are two members of the pro-inflammatory cytokines which act as significant components of the immune system during certain inflammatory diseases. Along with immunological processes, genetic factors play major roles in predisposition to PCOS. There are myriad single nucleotide polymorphisms (SNPs) within IL-17A and IL-32 genes that may affect their production and the susceptibility of individuals to PCOS. The objective of the present research was to investigate the association between IL-17A (rs2275913) and IL-32 (rs9927163, rs4786370) SNPs, and also their serum levels with susceptibility to PCOS in a group of Iranian women. In this case-control study, 150 PCOS patients (mean age of 29.1 years) and 150 healthy women (mean age of 26.1 years) were analyzed in terms of IL-17A and IL-32 SNPs via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Furthermore, serum levels of IL-17A and IL-32 cytokines were measured through the use of ELISA method. There were significant differences between PCOS and healthy women regarding IL-17A rs2275913 alleles, genotypes frequencies (p=0.005, and 0.01, respectively) and the allelic distribution of IL-32 rs9927163 SNP (p=0.03). Additionally, significant differences were indicated between two groups concerning the AG genotype against AA+GG genotypes (p=0.009) and the GG genotype against AA+AG genotypes (p=0.006) in IL-17A rs2275913 SNP. In the matter of IL-32 gene SNPs, GC haplotype frequency was significantly different between patients and controls (p=0.05). Furthermore, IL-32 serum level was not significantly different between the two studied groups and the serum level of IL-17A was not detectable. In conclusion, IL-17A and IL-32 SNPs might be associated with predisposition to PCOS in Iranian women.

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