scholarly journals miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma

2011 ◽  
Vol 124 (17) ◽  
pp. 2997-3005 ◽  
Author(s):  
Min Deng ◽  
Hailin Tang ◽  
Yanhong Zhou ◽  
Ming Zhou ◽  
Wei Xiong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Growth ◽  
Tumor Growth And Invasion

scholarly journals PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (15) ◽  
pp. 13434-13447 ◽  
Author(s):  
Arthur Kwok Leung Cheung ◽  
Joseph Chok Yan Ip ◽  
Adrian Chi Hang Chu ◽  
Yue Cheng ◽  
Merrin Man Long Leong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Growth ◽  
Akt Signaling ◽  
Tumor Growth And Invasion

scholarly journals HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Chun Cheng ◽  
Jun Yang ◽  
Si-Wei Li ◽  
Guofu Huang ◽  
Chenxi Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Growth ◽  
Therapeutic Target ◽  
Histone Deacetylases ◽  
Migration And Invasion ◽  
Poor Overall Survival ◽  
Mesenchymal Transition ◽  
E Cadherin

AbstractHistone deacetylases (HDACs) are involved in tumor progression, and some have been successfully targeted for cancer therapy. The expression of histone deacetylase 4 (HDAC4), a class IIa HDAC, was upregulated in our previous microarray screen. However, the role of HDAC4 dysregulation and mechanisms underlying tumor growth and metastasis in nasopharyngeal carcinoma (NPC) remain elusive. Here, we first confirmed that the HDAC4 levels in primary and metastatic NPC tissues were significantly increased compared with those in normal nasopharyngeal epithelial tissues and found that high HDAC4 expression predicted a poor overall survival (OS) and progression-free survival (PFS). Functionally, HDAC4 accelerated cell cycle G1/S transition and induced the epithelial-to-mesenchymal transition to promote NPC cell proliferation, migration, and invasion in vitro, as well as tumor growth and lung metastasis in vivo. Intriguingly, knockdown of N-CoR abolished the effects of HDAC4 on the invasion and migration abilities of NPC cells. Mechanistically, HDAC3/4 binds to the E-cadherin promoter to repress E-cadherin transcription. We also showed that the HDAC4 inhibitor tasquinimod suppresses tumor growth in NPC. Thus, HDAC4 may be a potential diagnostic marker and therapeutic target in patients with NPC.

TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth

Cytokine ◽  
2015 ◽  
Vol 74 (1) ◽  
pp. 157-163 ◽  
Author(s):  
Mehdi Bourouba ◽  
Ahmed-Amine Zergoun ◽  
Joseph S. Maffei ◽  
Dalia Chila ◽  
Djamel Djennaoui ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Growth ◽  
Carcinoma Tumor

miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

2014 ◽  
Vol 450 (1) ◽  
pp. 857-862 ◽  
Author(s):  
Hongling Zhu ◽  
Jin Fang ◽  
Jichen Zhang ◽  
Zefei Zhao ◽  
Lianyong Liu ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Tumor Growth ◽  
Papillary Thyroid ◽  
Tumor Growth And Invasion

Composite Waves for a Cell Population System Modeling Tumor Growth and Invasion

2014 ◽  
pp. 401-429 ◽  
Author(s):  
Min Tang ◽  
Nicolas Vauchelet ◽  
Ibrahim Cheddadi ◽  
Irene Vignon-Clementel ◽  
Dirk Drasdo ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cell Population ◽  
System Modeling ◽  
Population System ◽  
A Cell ◽  
Tumor Growth And Invasion
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