scholarly journals Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice

2017 ◽  
Vol 14 (2) ◽  
pp. 1023-1036 ◽  
Author(s):  
Su-Jin Kang ◽  
Beom-Rak Choi ◽  
Seung-Hee Kim ◽  
Hae-Yeon Yi ◽  
Hye-Rim Park ◽  
...  
Keyword(s):  
Ultraviolet B ◽  
Pomegranate Juice ◽  
Hairless Mice ◽  
Beneficial Effects ◽  
Skin Photoaging

scholarly journals Thread Embedding Acupuncture Inhibits Ultraviolet B Irradiation-Induced Skin Photoaging in Hairless Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yoon-Jung Kim ◽  
Ha-Neui Kim ◽  
Mi-Sook Shin ◽  
Byung-Tae Choi
Keyword(s):  
Western Blot ◽  
Ultraviolet B ◽  
Skin Thickness ◽  
Therapeutic Effects ◽  
Skin Damage ◽  
Hairless Mice ◽  
Regulation Of Expression ◽  
Skin Photoaging ◽  
Ultraviolet B Irradiation ◽  
Based Medicine

Thread embedding acupuncture (TEA) is an acupuncture treatment applied to many diseases in Korean medical clinics because of its therapeutic effects by continuous stimulation to tissues. It has recently been used to enhance facial skin appearance and antiaging, but data from evidence-based medicine are limited. To investigate whether TEA therapy can inhibit skin photoaging by ultraviolet B (UVB) irradiation, we performed analyses for histology, histopathology, in situ zymography and western blot analysis in HR-1 hairless mice. TEA treatment resulted in decreased wrinkle formation and skin thickness (Epidermis;P=0.001versus UV) in UVB irradiated mice and also inhibited degradation of collagen fibers (P=0.010versus normal) by inhibiting proteolytic activity of gelatinase matrix-metalloproteinase-9 (MMP-9). Western blot data showed that activation of c-Jun N-terminal kinase (JNK) induced by UVB (P=0.002versus normal group) was significantly inhibited by TEA treatment (P=0.005versus UV) with subsequent alleviation of MMP-9 activation (P=0.048versus UV). These results suggest that TEA treatment can have anti-photoaging effects on UVB-induced skin damage by maintenance of collagen density through regulation of expression of MMP-9 and related JNK signaling. Therefore, TEA therapy may have potential roles as an alternative treatment for protection against skin damage from aging.

scholarly journals Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174042 ◽  
Author(s):  
Hui-Wen Chiu ◽  
Cheng-Hsien Chen ◽  
Yi-Jie Chen ◽  
Yung-Ho Hsu
Keyword(s):  
Far Infrared ◽  
Ultraviolet B ◽  
Hairless Mice ◽  
Skin Photoaging

scholarly journals Protection against UVB-Induced Wrinkle Formation in SKH-1 Hairless Mice: Efficacy of Tricin Isolated from Enzyme-Treated Zizania latifolia Extract

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2254 ◽  
Author(s):  
Joo-Myung Moon ◽  
Se-Ho Park ◽  
Kwang-Hwan Jhee ◽  
Seun-Ah Yang
Keyword(s):  
Collagen Fiber ◽  
Experimental Period ◽  
Skin Damage ◽  
Hairless Mice ◽  
Zizania Latifolia ◽  
Beneficial Effects ◽  
Fiber Degradation ◽  
Skin Photoaging ◽  
Uvb Exposure ◽  
Dose Dependent

Tricin, a flavone found mainly in rice bran and sugarcane, has various beneficial effects. It has proven to be a clinically safe and selective potent inhibitor of different cancer cell lines. In this study, we evaluated the efficacy of enzyme-treated Zizania latifolia (ETZL) and its major active compound tricin on skin photoaging in SKH-1 hairless mice. Tricin (0.3 mg/kg) and ETZL (50, 150, and 300 mg/kg) were orally administrated to mice for 14 weeks; no cytotoxicity was observed during the entire experimental period. After UVB exposure, we observed significant increases in keratinization, coarse wrinkles, loss of moisture, thickened epidermis, and collagen fiber degradation in the dorsal skin. These features of photoaging were significantly suppressed after oral administration of tricin or ETZL. In addition, the protein expression of collagen effectively increased in ETZL (150 and 300 mg/kg)-treated mice, while the increased metalloproteinase (MMP)-1 and MMP-3 expressions were reduced after exposure to tricin or ETZL, although the effects were not dose-dependent. These data indicate that ETZL may be effective for attenuation of UVB-induced skin damage and photoaging in hairless mice, possibly by inhibiting MMPs expression.

Different Carotenoid Enrichment in Two Climacteric Fruits after Post- Harvest UV-B Treatment

2020 ◽  
Vol 16 (2) ◽  
pp. 102-108
Author(s):  
Carolina F. Assumpção ◽  
Médelin M. da Silva ◽  
Vanessa S. Hermes ◽  
Annamaria Ranieri ◽  
Ester A. Ferreira ◽  
...  
Keyword(s):  
Bioactive Compound ◽  
Ultraviolet B ◽  
Low Flow ◽  
Control Treatment ◽  
Carotenoid Content ◽  
Post Harvest ◽  
Beneficial Effects ◽  
Fruit Skin ◽  
Compound Synthesis ◽  
Viable Method

Background: Ultraviolet B (UV-B) radiation is a promising and environmentally friendly technique, which in a low flow rate, can induce bioactive compound synthesis. This work aimed at evaluating the effectiveness of post-harvest UV-B treatment in order to improve carotenoid content in climacteric fruits like persimmon and guava fruits. Methods: The fruits were harvested at commercial maturity and placed into climatic chambers equipped with UV-B lamps. For control treatment, the UV-B lamps were covered by a benzophenone film, known to block the radiation. This radiation was applied during 48 hours and fruits were sampled at 25, 30 and 48 hours of each treatment. HPLC analysis was performed to separate and identify carotenoid compounds from fruit skin after a saponification process. Results: Fruit from 30 hours treatment began to present a carotenoid accumulation since the majority of analyzed compounds exhibited its synthesis stimulated from this time on. In persimmon skin, it was observed that the maximum content was reached after 48 hours of UV-B treatment. Conclusion: These results suggest that this post-harvest UV-B treatment can be an innovative and a viable method to induce beneficial effects on guava and mainly on persimmon fruit.

scholarly journals 4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 365 ◽  
Author(s):  
Audrey Swiader ◽  
Caroline Camaré ◽  
Paul Guerby ◽  
Robert Salvayre ◽  
Anne Negre-Salvayre
Keyword(s):  
Lipid Peroxidation ◽  
Dermal Fibroblasts ◽  
Connective Tissues ◽  
Hairless Mice ◽  
Cultured Fibroblasts ◽  
Γh2ax Foci ◽  
Skin Photoaging ◽  
Actinic Elastosis

Solar ultraviolet A (UV-A) radiation promotes a huge variety of damages on connective tissues and dermal fibroblasts, including cellular senescence, a major contributor of skin photoaging. The mechanisms of skin photoaging evoked by UV-A partly involve the generation of reactive oxygen species and lipid peroxidation. We previously reported that 4-hydroxynonenal (HNE), a lipid peroxidation-derived aldehyde, forms adducts on elastin in the skins of UV-A irradiated hairless mice, possibly contributing to actinic elastosis. In the present study, we investigated whether and how HNE promotes fibroblast senescence in skin photoaging. Dermal fibroblasts of skins from UV-A-exposed hairless mice exhibited an increased number of γH2AX foci characteristic of cell senescence, together with an accumulation of HNE adducts partly colocalizing with the cytoskeletal protein vimentin. Murine fibroblasts exposed to UV-A radiation (two cycles of 15 J/cm2), or HNE (30 µM, 4 h), exhibited senescence patterns characterized by an increased γH2AX foci expression, an accumulation of acetylated proteins, and a decreased expression of the sirtuin SIRT1. HNE adducts were detected on vimentin in cultured fibroblasts irradiated by UV-A or incubated with HNE. The HNE scavenger carnosine prevented both vimentin modification and fibroblast senescence evoked by HNE in vitro and in the skins of UV-A-exposed mice. Altogether, these data emphasize the role of HNE and lipid peroxidation-derived aldehydes in fibroblast senescence, and confirm the protective effect of carnosine in skin photoaging.

scholarly journals Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless Mice

2015 ◽  
Vol 35 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Ki-Bae Hong ◽  
Yooheon Park ◽  
Jae Hwan Kim ◽  
Jin Man Kim ◽  
Hyung Joo Suh
Keyword(s):  
Ultraviolet B ◽  
Skin Damage ◽  
Hairless Mice

scholarly journals Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium

Antioxidants ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 128
Author(s):  
Grazia Maugeri ◽  
Agata Grazia D’Amico ◽  
Salvatore Giunta ◽  
Cesarina Giallongo ◽  
Daniele Tibullo ◽  
...  
Keyword(s):  
Corneal Epithelium ◽  
Apoptotic Cell ◽  
Ultraviolet B ◽  
Corneal Epithelial ◽  
Beneficial Effects ◽  
Pathway Activation ◽  
Dependent Protein ◽  
Radiation Induced ◽  
Ros Formation ◽  
Activity Dependent

The corneal epithelium, the outermost layer of the cornea, acts as a dynamic barrier preventing access to harmful agents into the intraocular space. It is subjected daily to different insults, and ultraviolet B (UV-B) irradiation represents one of the main causes of injury. In our previous study, we demonstrated the beneficial effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against UV-B radiation damage in the human corneal endothelium. Some of its effects are mediated through the activation of the intracellular factor, known as the activity-dependent protein (ADNP). In the present paper, we have investigated the role of ADNP and the small peptide derived from ADNP, known as NAP, in the corneal epithelium. Here, we have demonstrated, for the first time, ADNP expression in human and rabbit corneal epithelium as well as its protective effect by treating the corneal epithelial cells exposed to UV-B radiations with NAP. Our results showed that NAP treatment prevents ROS formation by reducing UV-B-irradiation-induced apoptotic cell death and JNK signalling pathway activation. Further investigations are needed to deeply investigate the possible therapeutic use of NAP to counteract corneal UV-B damage.

scholarly journals Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis

2018 ◽  
Vol 19 (11) ◽  
pp. 3551 ◽  
Author(s):  
Min Kang ◽  
Silvia Yumnam ◽  
Sun Kim
Keyword(s):  
Hyaluronic Acid ◽  
Oral Administration ◽  
Protein Expression ◽  
Ultraviolet B ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Hairless Mice ◽  
Uvb Irradiation ◽  
Collagen Peptide

Collagen peptide (CP) has beneficial effects on functions of the skin, such as skin barrier function and skin elasticity, in vivo. However, there are few studies investigating the mechanism underlying the potential effects of CP in skin epidermal moisturization after ultraviolet B (UVB) irradiation. In this study, we examined whether orally-administered CP affects the loss of skin hydration induced by UVB irradiation in hairless mice. SKH-1 hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB. The potential effects of CP were evaluated by measuring the transepidermal water loss (TEWL), skin hydration, wrinkle formation, and hyaluronic acid expression in the dorsal mice skin. We found that oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group. Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue. The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group. In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP. In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging. Therefore, we suggest that CP can be used as a nutricosmetic ingredient with potential effects on UVB-induced skin dehydration and moisture loss in addition to wrinkle formation.

scholarly journals Chemopreventive Effects of Sarcophine-diol on Ultraviolet B-induced Skin Tumor Development in SKH-1 Hairless Mice

Marine Drugs ◽  
2009 ◽  
Vol 7 (2) ◽  
pp. 153-165 ◽  
Author(s):  
Xiaoying Zhang ◽  
Ajay Bommareddy ◽  
Wei Chen ◽  
Michael Hildreth ◽  
Radhey Kaushik ◽  
...  
Keyword(s):  
Tumor Development ◽  
Ultraviolet B ◽  
Skin Tumor ◽  
Hairless Mice
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