scholarly journals Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless Mice

2015 ◽  
Vol 35 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Ki-Bae Hong ◽  
Yooheon Park ◽  
Jae Hwan Kim ◽  
Jin Man Kim ◽  
Hyung Joo Suh
Keyword(s):  
Ultraviolet B ◽  
Skin Damage ◽  
Hairless Mice

scholarly journals Protective effect of (-)-epigallocatechin gallate on ultraviolet b-induced skin damage in hairless mice

2016 ◽  
Vol 15 (6) ◽  
pp. 1183 ◽  
Author(s):  
Chang Liu ◽  
Xin-Qiang Zheng ◽  
Li-Ping Xiang ◽  
Jian-Liang Lu ◽  
Curt Anthony Polito ◽  
...  
Keyword(s):  
Protective Effect ◽  
Epigallocatechin Gallate ◽  
Ultraviolet B ◽  
Skin Damage ◽  
Hairless Mice

scholarly journals Thread Embedding Acupuncture Inhibits Ultraviolet B Irradiation-Induced Skin Photoaging in Hairless Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yoon-Jung Kim ◽  
Ha-Neui Kim ◽  
Mi-Sook Shin ◽  
Byung-Tae Choi
Keyword(s):  
Western Blot ◽  
Ultraviolet B ◽  
Skin Thickness ◽  
Therapeutic Effects ◽  
Skin Damage ◽  
Hairless Mice ◽  
Regulation Of Expression ◽  
Skin Photoaging ◽  
Ultraviolet B Irradiation ◽  
Based Medicine

Thread embedding acupuncture (TEA) is an acupuncture treatment applied to many diseases in Korean medical clinics because of its therapeutic effects by continuous stimulation to tissues. It has recently been used to enhance facial skin appearance and antiaging, but data from evidence-based medicine are limited. To investigate whether TEA therapy can inhibit skin photoaging by ultraviolet B (UVB) irradiation, we performed analyses for histology, histopathology, in situ zymography and western blot analysis in HR-1 hairless mice. TEA treatment resulted in decreased wrinkle formation and skin thickness (Epidermis;P=0.001versus UV) in UVB irradiated mice and also inhibited degradation of collagen fibers (P=0.010versus normal) by inhibiting proteolytic activity of gelatinase matrix-metalloproteinase-9 (MMP-9). Western blot data showed that activation of c-Jun N-terminal kinase (JNK) induced by UVB (P=0.002versus normal group) was significantly inhibited by TEA treatment (P=0.005versus UV) with subsequent alleviation of MMP-9 activation (P=0.048versus UV). These results suggest that TEA treatment can have anti-photoaging effects on UVB-induced skin damage by maintenance of collagen density through regulation of expression of MMP-9 and related JNK signaling. Therefore, TEA therapy may have potential roles as an alternative treatment for protection against skin damage from aging.

scholarly journals Antioxidant and Anti-Inflammatory Effects of Shungite against Ultraviolet B Irradiation-Induced Skin Damage in Hairless Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ma. Easter Joy Sajo ◽  
Cheol-Su Kim ◽  
Soo-Ki Kim ◽  
Kwang Yong Shim ◽  
Tae-Young Kang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dorsal Side ◽  
Ultraviolet B ◽  
Mouse Serum ◽  
Molecular Signaling ◽  
Skin Damage ◽  
Proinflammatory Response ◽  
Hairless Mice ◽  
Anti Inflammatory

As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored thein vivoeffects of shungite against ultraviolet B- (UVB-) induced skin damage by investigating the physiological skin parameters, immune-redox profiling, and oxidative stress molecular signaling. Toward this, mice were UVB-irradiated with 0.75 mW/cm2for two consecutive days. Consecutively, shungite was topically applied on the dorsal side of the mice for 7 days. First, we found significant improvements in the skin parameters of the shungite-treated groups revealed by the reduction in roughness, pigmentation, and wrinkle measurement. Second, the immunokine profiling in mouse serum and skin lysates showed a reduction in the proinflammatory response in the shungite-treated groups. Accordingly, the redox profile of shungite-treated groups showed counterbalance of ROS/RNS and superoxide levels in serum and skin lysates. Last, we have confirmed the involvement of Nrf2- and MAPK-mediated oxidative stress pathways in the antioxidant mechanism of shungite. Collectively, the results clearly show that shungite has an antioxidant and anti-inflammatory action against UVB-induced skin damage in hairless mice.

scholarly journals Protective Effects of Kuding Tea (Ilex kudingcha C. J. Tseng) Polyphenols on UVB-Induced Skin Aging in SKH1 Hairless Mice

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1016 ◽  
Author(s):  
Ruokun Yi ◽  
Jing Zhang ◽  
Peng Sun ◽  
Yu Qian ◽  
Xin Zhao
Keyword(s):  
Uv Light ◽  
Skin Aging ◽  
Ultraviolet B ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Precipitation Method ◽  
Protective Effects ◽  
Skin Damage ◽  
Hairless Mice ◽  
Necrosis Factor Alpha

In this study, the protective effects of Kuding tea polyphenols (KTPs) on ultraviolet B (UVB)-induced skin injury of SKH1 hairless mice were studied. The ion precipitation method was used for extraction of polyphenols from Kuding tea. High-performance liquid chromatography showed that KTPs contains chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, isochlorogenic acid A, and isochlorogenic acid C. SKH1 hairless mice were induced skin aging using 2.0 mW/s intensity of 90 mJ/cm2 UV light once a day for seven weeks. The 2.5% and 5% KTPs solution was smeared on 2 cm2 of back skin of skin aging mice twice a day. Mouse experiments showed that KTP strongly increased the serum levels of total superoxide dismutase (T-SOD) and catalase (CAT) and reduced those of malondialdehyde, interleukin 6 (IL-6), IL-1β, and tumor necrosis factor alpha (TNF-α) in mice with UVB-induced skin damage. KTP also increased the levels of type 1 collagen (Col I), hydroxyproline, and hyaluronic acid and reduced those of Col III and hydrogen peroxide in the damaged skin tissues of mice. Pathological observations of tissues stained with H & E, Masson’s trichrome, Verhoeff, and toluidine blue showed that KTPs could protect skin cells, collagen, and elastin and decrease the number of mast cells, thus inhibiting skin damage. Quantitative PCR and western blot assays showed that KTP upregulated the mRNA and protein expression of tissue inhibitor of metalloproteinase 1 (TIMP-1), TIMP-2, copper/zinc-SOD, manganese-SOD, CAT, and glutathione peroxidase and downregulated the expression of matrix metalloproteinase 2 (MMP-2) and MMP-9. In addition, the same concentration of KTP had stronger protective effects than vitamin C. The results of this study demonstrate that KTPs have good skin protective effects, as they are able to inhibit UVB-induced skin damage.

Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect

2013 ◽  
Vol 60 ◽  
pp. 123-129 ◽  
Author(s):  
Chiang-Wen Lee ◽  
Horng-Huey Ko ◽  
Chun-Ching Lin ◽  
Chee-Yin Chai ◽  
Wan-Tzu Chen ◽  
...  
Keyword(s):  
Ultraviolet B ◽  
Skin Damage ◽  
Hairless Mice ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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