scholarly journals Thread Embedding Acupuncture Inhibits Ultraviolet B Irradiation-Induced Skin Photoaging in Hairless Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yoon-Jung Kim ◽  
Ha-Neui Kim ◽  
Mi-Sook Shin ◽  
Byung-Tae Choi
Keyword(s):  
Western Blot ◽  
Ultraviolet B ◽  
Skin Thickness ◽  
Therapeutic Effects ◽  
Skin Damage ◽  
Hairless Mice ◽  
Regulation Of Expression ◽  
Skin Photoaging ◽  
Ultraviolet B Irradiation ◽  
Based Medicine

Thread embedding acupuncture (TEA) is an acupuncture treatment applied to many diseases in Korean medical clinics because of its therapeutic effects by continuous stimulation to tissues. It has recently been used to enhance facial skin appearance and antiaging, but data from evidence-based medicine are limited. To investigate whether TEA therapy can inhibit skin photoaging by ultraviolet B (UVB) irradiation, we performed analyses for histology, histopathology, in situ zymography and western blot analysis in HR-1 hairless mice. TEA treatment resulted in decreased wrinkle formation and skin thickness (Epidermis;P=0.001versus UV) in UVB irradiated mice and also inhibited degradation of collagen fibers (P=0.010versus normal) by inhibiting proteolytic activity of gelatinase matrix-metalloproteinase-9 (MMP-9). Western blot data showed that activation of c-Jun N-terminal kinase (JNK) induced by UVB (P=0.002versus normal group) was significantly inhibited by TEA treatment (P=0.005versus UV) with subsequent alleviation of MMP-9 activation (P=0.048versus UV). These results suggest that TEA treatment can have anti-photoaging effects on UVB-induced skin damage by maintenance of collagen density through regulation of expression of MMP-9 and related JNK signaling. Therefore, TEA therapy may have potential roles as an alternative treatment for protection against skin damage from aging.

Protective effect ofhochuekkito, a Kampo prescription, against ultraviolet B irradiation-induced skin damage in hairless mice

2013 ◽  
Vol 40 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Shigeto YANAGIHARA ◽  
Hiromi KOBAYASHI ◽  
Hisashi TAMIYA ◽  
Daisuke TSURUTA ◽  
Yuri OKANO ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ultraviolet B ◽  
Skin Damage ◽  
Hairless Mice ◽  
Ultraviolet B Irradiation

scholarly journals Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless Mice

2015 ◽  
Vol 35 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Ki-Bae Hong ◽  
Yooheon Park ◽  
Jae Hwan Kim ◽  
Jin Man Kim ◽  
Hyung Joo Suh
Keyword(s):  
Ultraviolet B ◽  
Skin Damage ◽  
Hairless Mice

scholarly journals Hydrangea serrata (Thunb.) Ser. Extract Attenuate UVB-Induced Photoaging through MAPK/AP-1 Inactivation in Human Skin Fibroblasts and Hairless Mice

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 533 ◽  
Author(s):  
Hee-Soo Han ◽  
Ji-Sun Shin ◽  
Da-Bin Myung ◽  
Hye Ahn ◽  
Sun Lee ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Mapk Signaling ◽  
Collagen Degradation ◽  
Hot Water ◽  
Mrna Levels ◽  
Skin Damage ◽  
Hairless Mice ◽  
Skin Photoaging ◽  
Mapk Signaling Pathways

Skin photoaging is mainly caused by exposure to ultraviolet (UV) light, which increases expressions of matrix metalloproteinases (MMPs) and destroys collagen fibers, consequently inducing wrinkle formation. Nutritional factors have received scientific attention for use as agents for normal skin functions. The aim of this study was to investigate the effect of hot water extracts from the leaves of Hydrangea serrata (Thunb.) Ser. (WHS) against ultraviolet B (UVB)-induced skin photoaging and to elucidate the underlying molecular mechanisms in human foreskin fibroblasts (Hs68) and HR-1 hairless mice. WHS recovered UVB-reduced cell viability and ameliorated oxidative stress by inhibiting intracellular reactive oxygen species (ROS) generation in Hs68 cells. WHS rescued UVB-induced collagen degradation by suppressing MMP expression, and reduced the mRNA levels of inflammatory cytokines. These anti-photoaging activities of WHS were associated with inhibition of the activator protein 1 (AP-1), signal transduction and activation of transcription 1 (STAT1), and mitogen-activated protein kinase (MAPK) signaling pathways. Oral administration of WHS effectively alleviated dorsal skin from wrinkle formation, epidermal thickening, collagen degradation, and skin dehydration in HR-1 hairless mice exposed to UVB. Notably, WHS suppressed UVB activation of the AP-1 and MAPK signaling pathways in dorsal mouse skin tissues. Taken together, our data indicate that WHS prevents UVB-induced skin damage due to collagen degradation and MMP activation via inactivation of MAPK/AP-1 signaling pathway.

scholarly journals Protective effect of (-)-epigallocatechin gallate on ultraviolet b-induced skin damage in hairless mice

2016 ◽  
Vol 15 (6) ◽  
pp. 1183 ◽  
Author(s):  
Chang Liu ◽  
Xin-Qiang Zheng ◽  
Li-Ping Xiang ◽  
Jian-Liang Lu ◽  
Curt Anthony Polito ◽  
...  
Keyword(s):  
Protective Effect ◽  
Epigallocatechin Gallate ◽  
Ultraviolet B ◽  
Skin Damage ◽  
Hairless Mice

scholarly journals Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice

2017 ◽  
Vol 14 (2) ◽  
pp. 1023-1036 ◽  
Author(s):  
Su-Jin Kang ◽  
Beom-Rak Choi ◽  
Seung-Hee Kim ◽  
Hae-Yeon Yi ◽  
Hye-Rim Park ◽  
...  
Keyword(s):  
Ultraviolet B ◽  
Pomegranate Juice ◽  
Hairless Mice ◽  
Beneficial Effects ◽  
Skin Photoaging
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