scholarly journals Effect of low-dose diuretics on the level of serum cystatin C and prognosis in patients with asymptomatic chronic heart failure

2015 ◽  
Vol 10 (6) ◽  
pp. 2345-2350 ◽  
Author(s):  
YUAN ZHANG ◽  
YANMING LI ◽  
GUANCHANG CHENG
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cystatin C ◽  
Low Dose ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Chuanhe Wang ◽  
Su Han ◽  
Fei Tong ◽  
Ying Li ◽  
Zhichao Li ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cystatin C ◽  
Cardiovascular Mortality ◽  
Retrospective Cohort ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
All Cause Mortality ◽  
Long Term Prognosis

Aim: The present study was established to investigate the use of the serum cystatin C/prealbumin (Cys-C/PAB) ratio as a predictive factor for long-term prognosis in patients with chronic heart failure.Methods: We divided our retrospective cohort of 6,311 patients admitted to hospital due to an episode of heart failure (HF) into three groups according to the Cys-C/PAB ratio. The endpoints were cardiovascular and all-cause mortality. Median follow-up time were 3.3 years (2–8 years), during which 2,945 (46.7%) patients died.Results: The Cys-C/PAB ratio was revealed to be an independent predictor of cardiovascular mortality (HR: 1.12, 95% CI: 1.15–1.23, P < 0.01) and all-cause mortality (HR: 1.19, 95% CI: 1.13–1.24, P < 0.01) by multivariable Cox analysis. Integrated discrimination improvement (IDI) showed that the Cys-C/PAB ratio in conjunction with the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) conferred a significant improvement in predicting individual risks of cardiovascular (P = 0.023) and all-cause (P = 0.028) mortality. For those with a high Cys-C/PAB ratio in combination with a high NT-proBNP level, the long-term cardiovascular mortality risk ratio was 8.6-times higher than for those with low values, and 7.51-times for all-cause mortality. Our study also showed that Cys-C/PAB and NT-proBNP in combination displayed higher value for the prediction of cardiovascular and all-cause in-hospital mortality in patients with HF.Conclusions: The Cys-C/PAB ratio is valuable for predicting cardiovascular and all-cause mortality in patients with HF and offers additional information to that provided by NT-proBNP.

scholarly journals Prognostic Value of Serum Cystatin C in Patients after Acute Heart Failure

2012 ◽  
Vol 25 (5) ◽  
pp. 625-625
Author(s):  
Wei-fu OU-YANG ◽  
Wen-qiang JIANG ◽  
Mei-qun HUANG ◽  
Lian-zhen YE ◽  
Min-jing CHEN
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Cystatin C ◽  
Prognostic Value ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals A Comparative Study of Serum Cystatin C, Serum Electrolytes, Urea and Creatinine in Early Detection of Kidney Injuries in Albino Rats Exposed to Formaldehyde

2021 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Michael Chinedu Olisah ◽  
◽  
Samuel C. Meludu ◽  
Keyword(s):  
Cystatin C ◽  
Low Dose ◽  
Control Group ◽  
Albino Rats ◽  
High Dose ◽  
Serum Cystatin C ◽  
Serum Electrolytes ◽  
Serum Cystatin ◽  
Group A ◽  
Group B

Aim: To ascertain early detection of possible kidney injuries in albino rats exposed to formaldehyde by assessing cystatin C, serum electrolytes, urea and creatinine. Materials/Methods: Thirty healthy adult male albino rats, weighing between 100 to 120 grams were randomly divided into three groups A, B and C. Group A served as control. Group B was exposed to low dose (100ppm of Formaldehyde), 3 hrs per day for four weeks, while group C was exposed to high Dose-200ppm of formaldehyde 3 hrs per day for four weeks. At the end of the exposure period, the rats were sacrificed by decapitation under chloroform anesthesia, and 4 ml of blood samples was collected from each rat into a plain bottle. The whole blood was allowed to clot, retracted and centrifuged at 3000 rpm for 10 minutes and serum separated. The serum was stored at -20˚C until analyses for serum electrolytes, creatinine and cystatin C. Serum electrolytes were determined using Ion selective electrode, urea and creatinine were determined using spectrophotometric methods while cystatin C was analyzed using Eliza. Data obtained was analyzed using SPSS. Results: The concentrations of the serum electrolytes, sodium. Potassium, bicarbonate and chloride were compared across the three group, they were not statistically significant (p>0.05). Urea was significantly higher in group C when compared with low dose B and control group A (P<0.05). Also, when the low dose group B was compared with the high dose group C, it was statistically significant. Creatinine concentrations were significantly higher in group C when compared with the control group A, while group B was not significant when compared with group A. Finally, the cystatin C concentrations were also significant when groups B, C were compared with the control group. Conclusion: Formaldehyde exposures may induce a gradual deterioration of renal functions in chronically exposed albino rats. Serum electrolytes, urea and creatinine may not be sufficient to indicate an early signs of kidney damage. From the study, serum cystatin C may be a better marker of renal impairment in early stages.

Prognostic value of serum cystatin C and N-terminal pro b-type natriuretic peptide in patients with acute heart failure

2012 ◽  
Vol 23 (7) ◽  
pp. 599-603 ◽  
Author(s):  
Juan Ignacio Pérez-Calvo ◽  
Francisco José Ruiz-Ruiz ◽  
Francisco Javier Carrasco-Sánchez ◽  
José Luis Morales-Rull ◽  
Sergio Manzano-Fernández ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Natriuretic Peptide ◽  
Cystatin C ◽  
Prognostic Value ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
C And N
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