scholarly journals Prognostic Value of Serum Cystatin C in Patients after Acute Heart Failure

2012 ◽  
Vol 25 (5) ◽  
pp. 625-625
Author(s):  
Wei-fu OU-YANG ◽  
Wen-qiang JIANG ◽  
Mei-qun HUANG ◽  
Lian-zhen YE ◽  
Min-jing CHEN
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Cystatin C ◽  
Prognostic Value ◽  
Serum Cystatin C ◽  
Serum Cystatin

Prognostic value of serum cystatin C and N-terminal pro b-type natriuretic peptide in patients with acute heart failure

2012 ◽  
Vol 23 (7) ◽  
pp. 599-603 ◽  
Author(s):  
Juan Ignacio Pérez-Calvo ◽  
Francisco José Ruiz-Ruiz ◽  
Francisco Javier Carrasco-Sánchez ◽  
José Luis Morales-Rull ◽  
Sergio Manzano-Fernández ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Natriuretic Peptide ◽  
Cystatin C ◽  
Prognostic Value ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
C And N

Prognostic Value of Cystatin C-Derived Estimated Glomerular Filtration Rate in Patients with Acute Heart Failure

2020 ◽  
Vol 10 (4) ◽  
pp. 232-242 ◽  
Author(s):  
Se Yong Jang ◽  
Dong Heon Yang ◽  
Hyeon Jeong Kim ◽  
Bo Eun Park ◽  
Yoon Jung Park ◽  
...  
Keyword(s):  
Heart Failure ◽  
Glomerular Filtration ◽  
Acute Heart Failure ◽  
Cystatin C ◽  
Prognostic Value ◽  
Survival Curve ◽  
Characteristic Curve ◽  
Curve Analysis ◽  
Disease Epidemiology

Background: Renal function is closely related to cardiac function and an important prognostic marker in heart failure. Objective: We aimed to test the prognostic value of cystatin C (cysC)-derived estimated glomerular filtration rates (eGFR) in comparison with eGFRs from creatinine solely based equations in patients with acute heart failure (AHF). Methods: This study included 262 patients (65.8 ± 14.9 years old, 126 male) with AHF. Prognostic value of the eGFRs, from cysC-based equations chronic kidney disease epidemiology collaboration (CKD-EPI-cysC and CKD-EPI-creatinine [cr]-cysC equations) were compared with eGFRs calculated from serum creatinine levels only (Modification of Diet in Renal Disease [MDRD]-4 and CKD-EPI-cr equations). Prognosis was evaluated with the composite of all-cause mortality and hospitalization for heart failure within 1 year. Results: During the follow-up period (mean follow-up period, 264.0 ± 136.1 days), 67 (25.6%) events occurred. Estimated GFR using CKD-EPI-cysC was the best for predicting 1-year outcome using receiver operating characteristic curve analysis (area under curve 0.585, 0.607, 0.669, and 0.652 for eGFRs from MDRD-4, CKD-EPI-cr, CKD-EPI-cysC, and CKD-EPI-cr-cysC respectively). The Kaplan-Meier survival curve analysis showed that only the eGFRs classification from the equations based on cysC significantly predicted 1-year outcome in patients with AHF. Conclusions: Estimated GFRs calculated with cysC predicted the prognosis more accurately in patients with AHF than the eGFRs from creatinine only equations.

scholarly journals Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Chuanhe Wang ◽  
Su Han ◽  
Fei Tong ◽  
Ying Li ◽  
Zhichao Li ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cystatin C ◽  
Cardiovascular Mortality ◽  
Retrospective Cohort ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
All Cause Mortality ◽  
Long Term Prognosis

Aim: The present study was established to investigate the use of the serum cystatin C/prealbumin (Cys-C/PAB) ratio as a predictive factor for long-term prognosis in patients with chronic heart failure.Methods: We divided our retrospective cohort of 6,311 patients admitted to hospital due to an episode of heart failure (HF) into three groups according to the Cys-C/PAB ratio. The endpoints were cardiovascular and all-cause mortality. Median follow-up time were 3.3 years (2–8 years), during which 2,945 (46.7%) patients died.Results: The Cys-C/PAB ratio was revealed to be an independent predictor of cardiovascular mortality (HR: 1.12, 95% CI: 1.15–1.23, P < 0.01) and all-cause mortality (HR: 1.19, 95% CI: 1.13–1.24, P < 0.01) by multivariable Cox analysis. Integrated discrimination improvement (IDI) showed that the Cys-C/PAB ratio in conjunction with the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) conferred a significant improvement in predicting individual risks of cardiovascular (P = 0.023) and all-cause (P = 0.028) mortality. For those with a high Cys-C/PAB ratio in combination with a high NT-proBNP level, the long-term cardiovascular mortality risk ratio was 8.6-times higher than for those with low values, and 7.51-times for all-cause mortality. Our study also showed that Cys-C/PAB and NT-proBNP in combination displayed higher value for the prediction of cardiovascular and all-cause in-hospital mortality in patients with HF.Conclusions: The Cys-C/PAB ratio is valuable for predicting cardiovascular and all-cause mortality in patients with HF and offers additional information to that provided by NT-proBNP.

Diagnostic and prognostic value of cystatin C in acute heart failure

2017 ◽  
Vol 50 (18) ◽  
pp. 1007-1013 ◽  
Author(s):  
Tobias Breidthardt ◽  
Zaid Sabti ◽  
Ronny Ziller ◽  
Frank Rassouli ◽  
Raphael Twerenbold ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Cystatin C ◽  
Prognostic Value ◽  
Diagnostic And Prognostic Value
Sign in / Sign up

Export Citation Format

Share Document