scholarly journals Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension

2017 ◽  
Author(s):  
Ikuyo Tsukamoto ◽  
Shiori Sugawara
Keyword(s):  
Arachidonic Acid ◽  
Linoleic Acid ◽  
Linolenic Acid ◽  
Plasma Phospholipids ◽  
Low Levels

scholarly journals Recovery of Fatty Acid Composition in Mediterranean Yellowtail (Seriola dumerili, Risso 1810) fed a Fish-Oil Finishing Diet

2020 ◽  
Vol 21 (14) ◽  
pp. 4871
Author(s):  
Francesco Bordignon ◽  
Silvia Martínez-Llorens ◽  
Angela Trocino ◽  
Miguel Jover-Cerdá ◽  
Ana Tomás-Vidal
Keyword(s):  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Eicosapentaenoic Acid ◽  
Fish Oil ◽  
Linolenic Acid ◽  
Vegetable Oils ◽  
Fa Composition

The present study evaluated the effects of wash-out on the fatty acid (FA) composition in the muscles of Mediterranean yellowtail. After 109 days during which fish were fed either a fish oil (FO)-based diet (FO 100) or a diet (FO 0) in which FO was completely substituted by vegetable oils, all fish were subjected to a wash-out with FO 100 diet for 90 days. The FA profile of muscles in fish fed FO 0 diet at the beginning of the experiment reflected that of dietary vegetable oils, rich in linoleic acid (LA), and α-linolenic acid (ALA), and was deficient in AA (arachidonic acid), EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid). No essential FA were fully restored in fish previously fed FO 0 diet on 45th or 90th day of wash-out. At the end of wash-out, the FA composition showed that AA, EPA, and DHA in the white muscles increased by +33%, +16%, and +43% (p < 0.001), respectively. Similarly, AA and DHA in the red muscles increased by +33% and +41% respectively, while EPA remained similar to fish fed FO 0 diet exclusively. Therefore, a 90-d wash-out can partially improve the FA profile in muscles of Mediterranean yellowtail previously fed vegetable oil-based diets.

scholarly journals Polyunsaturated fatty acids and risk of Alzheimer’s disease: a Mendelian randomization study

2019 ◽  
Vol 59 (4) ◽  
pp. 1763-1766 ◽  
Author(s):  
Yasutake Tomata ◽  
Susanna C. Larsson ◽  
Sara Hägg
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Linolenic Acid ◽  
Mendelian Randomization ◽  
Docosapentaenoic Acid ◽  
Alpha Linolenic Acid

Abstract Purpose Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer’s disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. Methods We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of n-6 PUFAs (linoleic acid, arachidonic acid) and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for AD from a genome-wide association meta-analysis of 63,926 individuals (21,982 diagnosed AD cases, 41,944 controls). Results None of the genetically predicted PUFAs was significantly associated with AD risk; odds ratios (95% confidence interval) per 1 SD increase in PUFA levels were 0.98 (0.93, 1.03) for linoleic acid, 1.01 (0.98, 1.05) for arachidonic acid, 0.96 (0.88, 1.06) for alpha-linolenic acid, 1.03 (0.93, 1.13) for eicosapentaenoic acid, 1.03 (0.97, 1.09) for docosapentaenoic acid, and 1.01 (0.81, 1.25) for docosahexaenoic acid. Conclusions This study did not support the hypothesis that PUFAs decrease AD risk.

Fatty acid composition of tissue phospholipids of the foetal calf and neonatal lamb, deer calf and piglet as compared with the cow, sheep, deer and pig

1978 ◽  
Vol 39 (1) ◽  
pp. 45-52 ◽  
Author(s):  
E. Payne
Keyword(s):  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Acid Composition ◽  
Protein Supplements ◽  
Neonatal Piglets ◽  
Brain Phospholipids ◽  
Low Levels ◽  
Neonatal Lambs

1. The fatty acid compositions of muscle and brain phospholipids of foetal calves, neonatal lambs, deer calves and piglets, and mature cattle, sheep, deer and pigs were determined. The cattle, sheep and deer had previously grazed ryegrass–clover pastures, and the pigs had been given rations based on barley. Two steers and four sheep had been given protected polyunsaturated lipid-protein supplements.2. In muscle phospholipids the values for triene:tetraene were 1.5 for neonatal lambs and 0.3 for foetal calves. Levels of linoleic acid were low compared with those in older animals but levels of the fatty acids 22:5ω3 and 22:6ω3 were comparatively high. For arachidonic acid there was little difference between young and mature animals.3. In muscle phospholipids of neonatal piglets and deer calves values for triene:tetraene were low. The piglet also had a low value for 22:5ω3:22:6ω3 compared with those in deer, calves or lambs. This ratio showed a proportionately greater increase with maturity in the pig than in cattle and sheep. Whilst the neonatal deer had higher linoleic acid levels than the other young ruminants, the fatty acid composition of muscle phospholipids of mature deer was rather similar to that in other ruminants.4. Phospholipids of brain showed little difference in fatty acid composition between foetuses or neonates and the mature animals. There was higher 22:4ω6 content in the adult ruminant with even higher levels in sheep given protected polyunsaturated fat. Linoleic acid was barely evident in any animal. The 22:6ω3 content was as high in the foetal or neonatal ruminant brain as in the adult, and higher than in the piglet. The fatty acid composition of brain phospholipids of young deer was similar to that in other ruminants.5. In other tissue phospholipids in foetal or neonatal ruminants and piglets there were high levels of 22:6ω3 in liver and low levels in lung. The neonatal animals, in particular, had high palmitic acid levels in lung. Hearts of young ruminants contained high levels of 20:5ω3 and C16-aldehyde derived from plasmalogens. Piglet heart contained higher linoleic acid and arachidonic acid, possibly due to increased entry of linoleic acid across the placenta from the sow.

A MUTANT GENOTYPE OF FLAX (Linum usitatissimum L.) CONTAINING VERY LOW LEVELS OF LINOLENIC ACID IN ITS SEED OIL

1986 ◽  
Vol 66 (3) ◽  
pp. 499-503 ◽  
Author(s):  
A. G. GREEN
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Linum Usitatissimum ◽  
Seed Oil ◽  
Transgressive Segregation ◽  
Linolenic Acid Content ◽  
Mutant Genotype ◽  
Linum Usitatissimum L ◽  
Low Levels ◽  
Mutant Genes

Two flax (Linum usitatissimum L.) mutants having reduced linolenic acid content in their seed oil (M1589 = 19.1% linolenic; M1722 = 23.4% linolenic) were crossed to determine whether further reductions could be achieved by recombination of the mutant genes. Extensive transgressive segregation was evident in the F2 for both linolenic acid (1.2–36.6%) and linoleic acid (14.7–55.2%), which were strongly negatively correlated (r = −0.97). F2 plants homozygous for both the M1589 and M1722 mutations had very low levels of linolenic acid (<2%) and high levels of linoleic acid (>46%).Key words: Flax, linseed, Linum usitatissimum, linoleic acid, linolenic acid, seed oil

FATTY ACID COMPOSITION OF PHOSPHATIDYL ETHANOL-AMINE AND PHOSPHATIDYL SERINE FROM DOG BILE

1964 ◽  
Vol 42 (3) ◽  
pp. 309-316 ◽  
Author(s):  
U. K. Misra ◽  
D. A. Turner
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Stearic Acid ◽  
Palmitic Acid ◽  
Linolenic Acid ◽  
Phosphatidyl Ethanolamine ◽  
Phosphatidyl Serine ◽  
Fatty Acid Analysis

Phosphatidyl ethanolamine and phosphatidyl serine extracted from dog bile have been separated by means of ammonium silicate column chromatography. Concentration of phosphatidyl serine in dog bile is about seven times higher than phosphatidyl ethanolamine. Fatty acid analysis by gas chromatography showed that phosphatidyl ethanolamine contains about 26% palmitic acid, 18% stearic acid, 11% linoleic acid, 2% linolenic acid, 9% arachidonic acid, 3% C22:5 fatty acid, and 6% C22:6 fatty acid. The concentrations of these fatty acids observed in phosphatidyl serine are different; palmitic acid represents about 43%, stearic acid 9%, linoleic acid 24%, linolenic acid a trace amount, and arachidonic acid 5%; C22:5 and C22:6 fatty acids are absent.

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