HIV type-1 drug resistance in antiretroviral treatment-naive adults infected with non-B subtype virus in the United Kingdom

2010 ◽  
Vol 15 (7) ◽  
pp. 985-991 ◽  
Author(s):  
Daniella N Chilton ◽  
◽  
Hannah Castro ◽  
Sam Lattimore ◽  
Linda J Harrison ◽  
...  
Keyword(s):  
Drug Resistance ◽  
United Kingdom ◽  
Antiretroviral Treatment ◽  
The United Kingdom ◽  
Treatment Naïve ◽  
Hiv Type 1

Recombinant Strains of HIV Type 1 in the United Kingdom

2001 ◽  
Vol 17 (5) ◽  
pp. 467-474 ◽  
Author(s):  
K.L. Barlow ◽  
I.D. Tatt ◽  
P.A. Cane ◽  
D. Pillay ◽  
J.P. Clewley
Keyword(s):  
United Kingdom ◽  
Recombinant Strains ◽  
The United Kingdom ◽  
Hiv Type 1

scholarly journals Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naïve Individuals

2009 ◽  
Vol 83 (6) ◽  
pp. 2645-2654 ◽  
Author(s):  
Stéphane Hué ◽  
Robert J. Gifford ◽  
David Dunn ◽  
Esther Fernhill ◽  
Deenan Pillay
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
United Kingdom ◽  
Phylogenetic Analyses ◽  
Antiretroviral Drugs ◽  
Cross Resistance ◽  
Transmitted Drug Resistance ◽  
The United Kingdom ◽  
Immunodeficiency Virus

ABSTRACT Transmission of human immunodeficiency virus (HIV) drug resistance is well-recognized and compromises response to first-line therapy. However, the population dynamics of transmitted resistance remains unclear, although previous models have assumed that such transmission reflects direct infection from treated individuals. We investigated whether population-based phylogenetic analyses would uncover lineages of resistant viruses circulating in untreated individuals. Through the phylogenetic analysis of 14,061 HIV type 1 (HIV-1) pol gene sequences generated in the United Kingdom from both treatment-naïve and -experienced individuals, we identified five treatment-independent viral clusters containing mutations conferring cross-resistance to antiretroviral drugs prescribed today in the United Kingdom. These viral lineages represent sustainable reservoirs of resistance among new HIV infections, independent of treatment. Dated phylogenies reconstructed through Bayesian Markov chain Monte Carlo inference indicated that these reservoirs originated between 1997 and 2003 and have persisted in the HIV-infected population for up to 8 years. Since our cohort does not represent all infected individuals within the United Kingdom, our results are likely to underestimate the number and size of the resistant reservoirs circulating among drug-naïve patients. The existence of sustained reservoirs of resistance in the absence of treatment has the capacity to threaten the long-term efficacy of antiretroviral therapy and suggests there is a limit to the decline of transmitted drug resistance. Given the current decrease in resistance transmitted from treated individuals, a greater proportion of resistance is likely to come from drug-naïve lineages. These findings provide new insights for the planning and management of treatment programs in resource-rich and developing countries.

Drug Resistance Mutations of HIV Type 1 Non-B Viruses to Integrase Inhibitors in Treatment-Naive Patients from Sub-Saharan Countries and Discordant Interpretations

2012 ◽  
Vol 28 (9) ◽  
pp. 1157-1160 ◽  
Author(s):  
Marjorie Monleau ◽  
Avelin F. Aghokeng ◽  
Benedicte A. Nkano ◽  
Marie-Laure Chaix ◽  
Martine Peeters, and the AC11/AC12 ANRS Wor
Keyword(s):  
Drug Resistance ◽  
Integrase Inhibitors ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Treatment Naïve ◽  
Hiv Type 1 ◽  
Sub Saharan

Prevalence of Drug Resistance-Related Polymorphisms in Treatment-Naive Individuals Infected with Nonsubtype B HIV Type 1 in Cameroon

2012 ◽  
Vol 28 (7) ◽  
pp. 675-684
Author(s):  
Ae S. Youngpairoj ◽  
George A. Alemnji ◽  
Laura T. Eno ◽  
Esther J. Lyonga ◽  
Mbia A Eloundou ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Treatment Naïve ◽  
Hiv Type 1
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