HIV type-1 drug resistance in treatment-naive patients monitored using minority species assays: a systematic review and meta-analysis

2011 ◽  
Vol 16 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Andrew J Buckton ◽  
Ross J Harris ◽  
Deenan Pillay ◽  
Patricia A Cane
Keyword(s):  
Systematic Review ◽  
Drug Resistance ◽  
Meta Analysis ◽  
Minority Species ◽  
Treatment Naïve ◽  
Hiv Type 1

Drug Resistance Mutations of HIV Type 1 Non-B Viruses to Integrase Inhibitors in Treatment-Naive Patients from Sub-Saharan Countries and Discordant Interpretations

2012 ◽  
Vol 28 (9) ◽  
pp. 1157-1160 ◽  
Author(s):  
Marjorie Monleau ◽  
Avelin F. Aghokeng ◽  
Benedicte A. Nkano ◽  
Marie-Laure Chaix ◽  
Martine Peeters, and the AC11/AC12 ANRS Wor
Keyword(s):  
Drug Resistance ◽  
Integrase Inhibitors ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Treatment Naïve ◽  
Hiv Type 1 ◽  
Sub Saharan

HIV type-1 drug resistance in antiretroviral treatment-naive adults infected with non-B subtype virus in the United Kingdom

2010 ◽  
Vol 15 (7) ◽  
pp. 985-991 ◽  
Author(s):  
Daniella N Chilton ◽  
◽  
Hannah Castro ◽  
Sam Lattimore ◽  
Linda J Harrison ◽  
...  
Keyword(s):  
Drug Resistance ◽  
United Kingdom ◽  
Antiretroviral Treatment ◽  
The United Kingdom ◽  
Treatment Naïve ◽  
Hiv Type 1

Prevalence of Drug Resistance-Related Polymorphisms in Treatment-Naive Individuals Infected with Nonsubtype B HIV Type 1 in Cameroon

2012 ◽  
Vol 28 (7) ◽  
pp. 675-684
Author(s):  
Ae S. Youngpairoj ◽  
George A. Alemnji ◽  
Laura T. Eno ◽  
Esther J. Lyonga ◽  
Mbia A Eloundou ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Treatment Naïve ◽  
Hiv Type 1

scholarly journals Transmitted drug resistance in newly diagnosed and treatment-naïve HIV type 1-infected patients in Hungary

2020 ◽  
Vol 20 ◽  
pp. 124-130
Author(s):  
Éva Áy ◽  
Viktor Müller ◽  
Mária Mezei ◽  
Ágnes Pocskay ◽  
Anita Koroknai ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Newly Diagnosed ◽  
Treatment Naïve ◽  
Hiv Type 1

Time in range for multiple technologies in type 1 diabetes: a systematic review and network meta-analysis

2020 ◽  
Author(s):  
Anthony Pease ◽  
Clement Lo ◽  
Arul Earnest ◽  
Velislava Kiriakova ◽  
Danny Liew ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 1 Diabetes ◽  
Closed Loop ◽  
Meta Analysis ◽  
Management Strategies ◽  
Glucose Testing ◽  
Closed Loop Systems ◽  
Percent Time ◽  
Time In Range

<b>Background: </b>Time-in-range is a key glycaemic metric, and comparisons of management technologies for this outcome are critical to guide device selection. <p><b> </b></p> <p><b>Purpose: </b>We conducted a systematic review and network meta-analysis to compare and rank technologies for time in glycaemic ranges.</p> <p> </p> <p><b>Data sources: </b>We searched All Evidenced Based Medicine Reviews, CINAHL, EMBASE, MEDLINE, MEDLINE In-Process and other non-indexed citations, PROSPERO, PsycINFO, PubMed, and Web of Science until 24 April, 2019.</p> <p> </p> <p><b>Study selection: </b>We included randomised controlled trials <u>></u>2 weeks duration comparing technologies for management of type 1 diabetes in adults (<u>></u>18 years of age), excluding pregnant women. </p> <p> </p> <p><b>Data extraction: </b>Data were extracted using a predefined template. Outcomes were percent time with sensor glucose levels 3.9–10.0mmol/l (70–180mg/dL), >10.0mmol/L (180mg/dL), and <3.9mmol/L (70mg/dL). </p> <p><b> </b></p> <p><b>Data synthesis: </b>We identified 16,772 publications, of which 14 eligible studies compared eight technologies comprising 1,043 participants. Closed loop systems lead to greater percent time-in-range than any other management strategy and was 17.85 (95% predictive interval [PrI] 7.56–28.14) higher than usual care of multiple daily injections with capillary glucose testing. Closed loop systems ranked best for percent time-in-range or above range utilising surface under the cumulative ranking curve (SUCRA–98.5 and 93.5 respectively). Closed loop systems also ranked highly for time below range (SUCRA–62.2). </p> <p><b> </b></p> <p><b>Limitations: </b>Overall risk of bias ratings were moderate for all outcomes. Certainty of evidence was very low.</p> <p><b> </b></p> <p><b>Conclusions: </b>In the first integrated comparison of multiple management strategies considering time-in-range, we found that the efficacy of closed loop systems appeared better than all other approaches. </p>

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