Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

10.3791/61593 ◽  
2021 ◽  
Author(s):  
Hirotoshi Yasui ◽  
Yuko Nishinaga ◽  
Shunichi Taki ◽  
Kazuomi Takahashi ◽  
Yoshitaka Isobe ◽  
...  
Keyword(s):  
Mouse Models ◽  
Near Infrared ◽  
Pleural Dissemination

scholarly journals Humanized Anti–Tumor-Associated Glycoprotein–72 for Submillimeter Near-Infrared Detection of Colon Cancer in Metastatic Mouse Models

2020 ◽  
Vol 252 ◽  
pp. 16-21 ◽  
Author(s):  
Hannah M. Hollandsworth ◽  
Siamak Amirfakhri ◽  
Filemoni Filemoni ◽  
Robert M. Hoffman ◽  
Justin Molnar ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Models ◽  
Near Infrared ◽  
Infrared Detection

scholarly journals Rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe

2020 ◽  
Vol 11 (12) ◽  
pp. 3141-3145
Author(s):  
Ling-Ling Wu ◽  
Qinghua Wang ◽  
Yali Wang ◽  
Na Zhang ◽  
Qingyang Zhang ◽  
...  
Keyword(s):  
Mouse Models ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Fluorogenic Probe ◽  
Live Bacteria

A new nitroreductase-responsive near-infrared fluorogenic probe can specifically image live bacteria in mouse models and does not accumulate at sites of inflammation or tumor.

Intraoperative Near-infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury: Reply

2010 ◽  
Vol 35 (3) ◽  
pp. 694-695 ◽  
Author(s):  
Jose-Luiz Figueiredo ◽  
Matthias Nahrendorf ◽  
Claudio Vinegoni ◽  
Ralph Weissleder
Keyword(s):  
Bile Duct ◽  
Mouse Models ◽  
Bile Duct Injury ◽  
Near Infrared ◽  
Fluorescent Cholangiography

scholarly journals Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Shaw-Wei D. Tsen ◽  
Luke E. Springer ◽  
Krishna Sharmah Gautam ◽  
Rui Tang ◽  
Kexian Liang ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Treatment Response ◽  
Fluorescence Imaging ◽  
Mouse Models ◽  
Near Infrared ◽  
Early Response ◽  
Annexin A2 ◽  
Whole Body ◽  
Invasive Monitoring ◽  
Non Invasive

Abstract Background The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of treatment response. Annexin A2, an inflammation-associated protein whose presence and phosphorylation levels are upregulated in RA, represents a potential molecular target for tracking RA treatment response. Methods LS301, a near-infrared dye-peptide conjugate that selectively targets tyrosine 23-phosphorylated annexin A2 (pANXA2), was evaluated for its utility in monitoring disease progression, remission, and early response to drug treatment in mouse models of RA by fluorescence imaging. The intraarticular distribution and localization of LS301 relative to pANXA2 was determined by histological and immunohistochemical methods. Results In mouse models of spontaneous and serum transfer-induced inflammatory arthritis, intravenously administered LS301 showed selective accumulation in regions of joint pathology including paws, ankles, and knees with positive correlation between fluorescent signal and disease severity by clinical scoring. Whole-body near-infrared imaging with LS301 allowed tracking of spontaneous disease remission and the therapeutic response after dexamethasone treatment. Histological analysis showed preferential accumulation of LS301 within the chondrocytes and articular cartilage in arthritic mice, and colocalization was observed between LS301 and pANXA2 in the joint tissue. Conclusions We demonstrate that fluorescence imaging with LS301 can be used to monitor the progression, remission, and early response to drug treatment in mouse models of RA. Given the ease of detecting LS301 with portable optical imaging devices, the agent may become a useful early treatment response reporter for arthritis diagnosis and drug evaluation.

scholarly journals Intraoperative Near-Infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury

2009 ◽  
Vol 34 (2) ◽  
pp. 336-343 ◽  
Author(s):  
Jose-Luiz Figueiredo ◽  
Cory Siegel ◽  
Matthias Nahrendorf ◽  
Ralph Weissleder
Keyword(s):  
Bile Duct ◽  
Mouse Models ◽  
Bile Duct Injury ◽  
Near Infrared ◽  
Fluorescent Cholangiography

scholarly journals Author response: Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

2019 ◽  
Author(s):  
Cassandra L Stowe ◽  
Thomas A Burley ◽  
Helen Allan ◽  
Maria Vinci ◽  
Gabriela Kramer-Marek ◽  
...  
Keyword(s):  
Mouse Models ◽  
Near Infrared ◽  
Bioluminescence Imaging ◽  
Author Response ◽  
Mouse Models Of Cancer

scholarly journals Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

2018 ◽  
Vol 56 (5) ◽  
pp. 3341-3355 ◽  
Author(s):  
Michele M. Comerota ◽  
Batbayar Tumurbaatar ◽  
Balaji Krishnan ◽  
Rakez Kayed ◽  
Giulio Taglialatela
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Near Infrared ◽  
Light Treatment ◽  
Infrared Light ◽  
Transgenic Mouse Models ◽  
Near Infrared Light ◽  
Tau Oligomers
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