scholarly journals Photobiomodulation with near infrared light mitigates Alzheimer’s disease-related pathology in cerebral cortex – evidence from two transgenic mouse models

2014 ◽  
Vol 6 (1) ◽  
pp. 2 ◽  
Author(s):  
Sivaraman Purushothuman ◽  
Daniel M Johnstone ◽  
Charith Nandasena ◽  
John Mitrofanis ◽  
Jonathan Stone
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Near Infrared ◽  
Infrared Light ◽  
Transgenic Mouse Models ◽  
Near Infrared Light

scholarly journals Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

2018 ◽  
Vol 56 (5) ◽  
pp. 3341-3355 ◽  
Author(s):  
Michele M. Comerota ◽  
Batbayar Tumurbaatar ◽  
Balaji Krishnan ◽  
Rakez Kayed ◽  
Giulio Taglialatela
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Near Infrared ◽  
Light Treatment ◽  
Infrared Light ◽  
Transgenic Mouse Models ◽  
Near Infrared Light ◽  
Tau Oligomers

Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia

2015 ◽  
Vol 591 ◽  
pp. 155-159 ◽  
Author(s):  
Sivaraman Purushothuman ◽  
Daniel M. Johnstone ◽  
Charith Nandasena ◽  
Janet van Eersel ◽  
Lars M. Ittner ◽  
...  
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Near Infrared ◽  
Infrared Light ◽  
Transgenic Mouse Models ◽  
Near Infrared Light

scholarly journals Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer’s Disease

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 870 ◽  
Author(s):  
Raluca Stefanescu ◽  
Gabriela Dumitriṭa Stanciu ◽  
Andrei Luca ◽  
Luminita Paduraru ◽  
Bogdan-Ionel Tamba
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Secondary Metabolites ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Beta Amyloid ◽  
Thioflavin T ◽  
Amyloid Angiopathy ◽  
Transgenic Mouse Models ◽  
Study Results

Alzheimer’s disease is a neurodegenerative disorder for which there is a continuous search of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed of 40 and 42 amino acids and are considered a major cause of neuronal toxicity. They are prone to aggregation, yielding oligomers and fibrils through the inter-molecular binding between the amino acid sequences (17–42) of multiple amyloid-beta molecules. Additionally, amyloid deposition causes cerebral amyloid angiopathy. The present study aims to identify, in the existing literature, natural plant derived products possessing inhibitory properties against aggregation. The studies searched proved the anti-aggregating effects by the thioflavin T assay and through behavioral, biochemical, and histological analysis carried out upon administration of natural chemical compounds to transgenic mouse models of Alzheimer’s disease. According to our present study results, fifteen secondary metabolites from plants were identified which presented both evidence coming from the thioflavin T assay and transgenic mouse models developing Alzheimer’s disease and six additional metabolites were mentioned due to their inhibitory effects against fibrillogenesis. Among them, epigallocatechin-3-gallate, luteolin, myricetin, and silibinin were proven to lower the aggregation to less than 40%.

Aβ38 in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models

2014 ◽  
Vol 39 (4) ◽  
pp. 871-881 ◽  
Author(s):  
Jochim Reinert ◽  
Henrik Martens ◽  
Melanie Huettenrauch ◽  
Tekla Kolbow ◽  
Lars Lannfelt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Transgenic Mouse Models ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease
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