scholarly journals Rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe

2020 ◽  
Vol 11 (12) ◽  
pp. 3141-3145
Author(s):  
Ling-Ling Wu ◽  
Qinghua Wang ◽  
Yali Wang ◽  
Na Zhang ◽  
Qingyang Zhang ◽  
...  
Keyword(s):  
Mouse Models ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Fluorogenic Probe ◽  
Live Bacteria

A new nitroreductase-responsive near-infrared fluorogenic probe can specifically image live bacteria in mouse models and does not accumulate at sites of inflammation or tumor.

scholarly journals Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against Staphylococcus aureus

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 52
Author(s):  
Atanu Naskar ◽  
Sohee Lee ◽  
Kwang-sun Kim
Keyword(s):  
Staphylococcus Aureus ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Au Nanoparticles ◽  
Synthesis Method ◽  
Antibacterial Properties ◽  
Black Phosphorus ◽  
Infrared Light ◽  
Resistant Bacteria ◽  
Near Infrared Light

Antibiotic therapy is the gold standard for bacterial infections treatment. However, the rapid increase in multidrug-resistant (MDR) bacterial infections and its recent use for secondary bacterial infections in many COVID-19 patients has considerably weakened its treatment efficacy. These shortcomings motivated researchers to develop new antibacterial materials, such as nanoparticle-based antibacterial platform with the ability to increase the chances of killing MDR strains and prevent their drug resistance. Herein, we report a new black phosphorus (BP)-based non-damaging near-infrared light-responsive platform conjugated with ZnO and Au nanoparticles as a synergistic antibacterial agent against Staphylococcus aureus species. First, BP nanosheets containing Au nanoparticles were assembled in situ with the ZnO nanoparticles prepared by a low-temperature solution synthesis method. Subsequently, the antibacterial activities of the resulting Au–ZnO–BP nanocomposite against the non-resistant, methicillin-resistant, and erythromycin-resistant S. aureus species were determined, after its photothermal efficacy was assessed. The synthesized nanocomposite exhibited excellent anti-S. aureus activity and good photothermal characteristics. The non-resistant S. aureus species did not produce drug-resistant bacteria after the treatment of multiple consecutive passages under the pressure of the proposed nanoantibiotic, but rapidly developed resistance to erythromycin. This work clearly demonstrates the excellent photothermal antibacterial properties of Au–ZnO–BP nanocomposite against the MDR S. aureus species.

Modular synthesis of silicon (IV) phthalocyanine conjugates bearing glycosylated axial ligands

2019 ◽  
Vol 23 (07n08) ◽  
pp. 850-855 ◽  
Author(s):  
Shamus A. L. Cooper ◽  
Kevin W. Graepel ◽  
Ricarda C. Steffens ◽  
David G. Dennis ◽  
Gabriel A. Cambroneo ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Clinical Utility ◽  
Near Infrared ◽  
Therapeutic Potential ◽  
Biological Fluids ◽  
Modular Approach ◽  
Specific Targeting ◽  
Axial Ligands ◽  
Carbohydrate Ligands ◽  
Reliable Methods

Phthalocyanines (Pcs) are near-infrared photosensitizers with therapeutic potential for the treatment of bacterial infections and cancer. However, their clinical utility has been hindered by poor solubility in biological fluids, lack of specificity, and limited clearance from affected tissues. Glycosylated Pcs have the potential to overcome these issues by providing increased solubility and tumor specific targeting. However, reliable methods for their synthesis remains challenging. Here we present our first approach towards the synthesis of a series of silicon (IV) phthalocyanine conjugates bearing axial carbohydrate ligands (CPcCs). The novelty of our approach lies in the installation of axial alkyne ligands which can be functionalized with readily accessible acetyl protected azido glycosides, thus providing a modular approach for the synthesis of these complex macromolecules.

scholarly journals Humanized Anti–Tumor-Associated Glycoprotein–72 for Submillimeter Near-Infrared Detection of Colon Cancer in Metastatic Mouse Models

2020 ◽  
Vol 252 ◽  
pp. 16-21 ◽  
Author(s):  
Hannah M. Hollandsworth ◽  
Siamak Amirfakhri ◽  
Filemoni Filemoni ◽  
Robert M. Hoffman ◽  
Justin Molnar ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Models ◽  
Near Infrared ◽  
Infrared Detection

scholarly journals A Highly Sensitive Fluorogenic Probe for Imaging Glycoproteins and Mucine Activity in Live Cells in the Near-Infrared Region

2018 ◽  
Vol 24 (24) ◽  
pp. 6344-6348 ◽  
Author(s):  
Cecilia Samaniego Lopez ◽  
Jimena Hebe Martínez ◽  
María Laura Uhrig ◽  
Federico Coluccio Leskow ◽  
Carla Cecilia Spagnuolo
Keyword(s):  
Near Infrared ◽  
Infrared Region ◽  
Live Cells ◽  
Fluorogenic Probe ◽  
Highly Sensitive ◽  
Near Infrared Region

scholarly journals Novel PET and Near Infrared Imaging Probes for the Specific Detection of Bacterial Infections Associated With Cardiac Devices

2019 ◽  
Vol 12 (5) ◽  
pp. 875-886 ◽  
Author(s):  
Kiyoko Takemiya ◽  
Xinghai Ning ◽  
Wonewoo Seo ◽  
Xiaojian Wang ◽  
Rafi Mohammad ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Specific Detection ◽  
Near Infrared Imaging ◽  
Cardiac Devices ◽  
Imaging Probes

A near-infrared fluorogenic probe with fast response for detecting sodium dithionite in living cells

2021 ◽  
Vol 245 ◽  
pp. 118887 ◽  
Author(s):  
Xizi Yu ◽  
Lie Xiang ◽  
Sheng Yang ◽  
Shuanglin Qu ◽  
Xianqing Zeng ◽  
...  
Keyword(s):  
Near Infrared ◽  
Fast Response ◽  
Sodium Dithionite ◽  
Living Cells ◽  
Fluorogenic Probe

Inherited Neutrophil Disorders

Hematology ◽  
2000 ◽  
Vol 2000 (1) ◽  
pp. 303-318 ◽  
Author(s):  
Mary C. Dinauer ◽  
Julie A. Lekstrom-Himes ◽  
David C. Dale
Keyword(s):  
Mouse Models ◽  
Host Defense ◽  
Neutrophil Elastase ◽  
Bacterial Infections ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone ◽  
Functional Responses ◽  
Congenital Neutropenia ◽  
Specific Granule ◽  
Cyclic Hematopoiesis

Recent advances in our understanding of the molecular basis of inherited neutrophil disorders and complementary studies in transgenic mouse models have provided new insights into the normal mechanisms regulating myelopoiesis and the functional responses of mature neutrophils. Neutrophil specific granule deficiency is a rare disorder of neutrophil function characterized by a lack of neutrophil secondary granule proteins and associated with recurrent bacterial infections. The CCAAT/enhancer binding protein (C/EBP) ϵ, a leucine zipper transcription factor expressed primarily in myeloid cells, and C/EBPϵ-deficient mice generated by gene targeting lack specific granules and have impaired host defense are discussed by Dr. Lekstrom-Himes in Section I. The similarity between these phenotypes led to the identification of a loss of function mutation in the C/EBPϵ gene in a subset of patients with specific granule deficiency. Dr. Dale reviews the clinical features and management of congenital neutropenia and cyclic hematopoiesis in Section II. Inherited mutations in the neutrophil elastase gene have recently been identified in both disorders. Specific mutations identified in cyclic and congenital neutropenia are described along with possible mechanisms for regulation of hematopoiesis by neutrophil elastase. In Section III, Dr. Dinauer reviews the molecular genetics of chronic granulomatous disease and studies in knockout mouse models. This work has revealed important features of the regulation of the respiratory burst oxidase and its role in host defense and inflammation. Results from preclinical studies and phase 1 clinical trials for gene therapy for CGD are summarized, in addition to alternative approaches using allogeneic bone marrow transplantation with nonmyeloablative conditioning.

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