scholarly journals A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

10.3791/55571 ◽  
2017 ◽  
Author(s):  
Christopher B. Erickson ◽  
Nichole Shaw ◽  
Nancy Hadley-Miller ◽  
Michael S. Riederer ◽  
Melissa D. Krebs ◽  
...  
Keyword(s):  
Growth Plate ◽  
Injury Model ◽  
Repair Mechanisms ◽  
Regeneration Strategies ◽  
Growth Plate Injury ◽  
Tibial Growth Plate

Characterization of a small animal growth plate injury model using microcomputed tomography

Bone ◽  
2010 ◽  
Vol 46 (6) ◽  
pp. 1555-1563 ◽  
Author(s):  
Rhima M. Coleman ◽  
Jennifer E. Phillips ◽  
Angela Lin ◽  
Zvi Schwartz ◽  
Barbara D. Boyan ◽  
...  
Keyword(s):  
Growth Plate ◽  
Small Animal ◽  
Microcomputed Tomography ◽  
Injury Model ◽  
Animal Growth ◽  
Growth Plate Injury

scholarly journals Comparison of mesenchymal stem cell sheets and chondrocyte sheets in a rabbit growth plate injury model

2020 ◽  
Vol 50 (4) ◽  
pp. 1082-1096
Author(s):  
Alper GÜLTEKİN ◽  
Yücel AĞIRDİL ◽  
Büşra Öncel DUMAN ◽  
Cansu Subaşı DEMİR ◽  
Erdal KARAÖZ
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Growth Plate ◽  
Cell Sheets ◽  
Injury Model ◽  
Growth Plate Injury

An ultrastructural study of mitotic chondrocytes in the proliferative zone of the rat tibial growth plate

1993 ◽  
Vol 175 (1) ◽  
pp. 41-45 ◽  
Author(s):  
S. Shibata ◽  
O. Baba ◽  
M. Niikura ◽  
S. Suzuki ◽  
Y. Yamashita ◽  
...  
Keyword(s):  
Growth Plate ◽  
Ultrastructural Study ◽  
Proliferative Zone ◽  
Tibial Growth Plate

scholarly journals Local Changes to the Distal Femoral Growth Plate Following Injury in Mice

2017 ◽  
Vol 139 (7) ◽  
Author(s):  
Lauren M. Mangano Drenkard ◽  
Meghan E. Kupratis ◽  
Katie Li ◽  
Louis C. Gerstenfeld ◽  
Elise F. Morgan
Keyword(s):  
Growth Plate ◽  
Skeletal Development ◽  
Global Changes ◽  
Mineral Density ◽  
Injury Site ◽  
Hypertrophic Zone ◽  
Proliferative Zone ◽  
Spatial Changes ◽  
Zonal Organization ◽  
Growth Plate Injury

Injury to the growth plate is associated with growth disturbances, most notably premature cessation of growth. The goal of this study was to identify spatial changes in the structure and composition of the growth plate in response to injury to provide a foundation for developing therapies that minimize the consequences for skeletal development. We used contrast-enhanced microcomputed tomography (CECT) and histological analyses of a murine model of growth plate injury to quantify changes in the cartilaginous and osseous tissue of the growth plate. To distinguish between local and global changes, the growth plate was divided into regions of interest near to and far from the injury site. We noted increased thickness and CECT attenuation (a measure correlated with glycosaminoglycan (GAG) content) near the injury, and increased tissue mineral density (TMD) of bone bridges within the injury site, compared to outside the injury site and contralateral growth plates. Furthermore, we noted disruption of the normal zonal organization of the physis. The height of the hypertrophic zone was increased at the injury site, and the relative height of the proliferative zone was decreased across the entire injured growth plate. These results indicate that growth plate injury leads to localized disruption of cellular activity and of endochondral ossification. These local changes in tissue structure and composition may contribute to the observed retardation in femur growth. In particular, the changes in proliferative and hypertrophic zone heights seen following injury may impact growth and could be targeted when developing therapies for growth plate injury.

scholarly journals Talus Arthritis Pattern in Juvenile Idiopathic Arthritis (JIA)

2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0009
Author(s):  
Mohammad Alkhreisat ◽  
Jayasree Ramas Ramaskandhan ◽  
Malik Siddique
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Growth Plate ◽  
Demographic Data ◽  
Weight Bearing ◽  
Joint Destruction ◽  
Time Frame ◽  
Valgus Deformity ◽  
X Rays ◽  
Number Of Patients ◽  
Tibial Growth Plate

Category: Ankle Arthritis Introduction/Purpose: Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age persist for more than 6 weeks. It is one of the main diseases affecting Paediatric age group Joints in a form of a chronic, long standing and debilitating disease. It is estimated that 1 in 1000 children present with JIA in the UK alone. Radiographic progression of the disease occurs early, and if not addressed may result in permanent joint destruction and poor functional outcomes. The ankle is frequently involved, but it is unclear whether this is due to synovitis, tenosynovitis. To date, no evidence of combined therapies or integrated care for juvenile idiopathic arthritis patients with F&A problems exists. Methods: JIA patients with ankle involvement presented to orthopedic foot and ankle services between 2012-2017 were include. All patients had weight bearing x-rays ankle measuring Tibio talar angle, also underwent Ankle MRI following standard hospital MRI protocols. The MRI scans were used to measure the affected areas in talus. Talus was divided into 4 anatomical regions (Anterio-medial, Anterio-lateral, posterior-medial, posterolateral). lesion involving wider areas were recorded as two or more regions accordingly, i.e.: AM and PM involvement at the same time were given yes for area of involvement in both region and recorded separately. Bilateral Ankles involvement were also recorded. Tibial growth plate involvement in these patients on the MRI scan was recorded. Demographic data was collected along with side, disease pattern, age at diagnosis and age at presentation to F&A speciality and patients requiring surgical intervention. Measurements were carried out by two in dependent orthopaedics F&A surgeons. Results: 14 patients were included in this study with a total of 17 ankles. 12 were females (N=12, 85.7%). Mean age was between 8-21 years (15.0 ± 4.08, M±SD). Time to presentation was 2.9 to 8.4 years (5.1 ± 1.4 years). 5 had Oligo-articular involvement (37.5%),9 patients had polyA (64.2%). 11/17 Right Ankles (64.7%), 3 left (21.4%). 3 bilateral (21.4%). 11/17 Ankles in Varus (64.7%), 1/17 valgus (5.8%), 5/17 neutral (29.4%). Mean Tibiotalar angle was 80° ± 13.5° (Range 49° - 100°). 12/17(70.5%) had involvement of the antero-medial part of the talus,1/17(5.8%)antero-lateral, 8/17 postero-medial(47.06%), 3/17(17.6%) postero-lateral . All the patients with postero-lateral involvement, they also had postero-medial involvement. (p=0.043). 13/17 ankles (76.4%) had tibial growth plate involvement. 5 patients (35.7%) had subsequent operations. Conclusion: This study shows a pattern of involvement in the talus and the effect this disease has on Tibiotalar alignment. This needs to be confirmed on a larger number of patients. And highlights the need for an earlier presentation of these patients to F&A surgeon to prevent the disease sequela. Further research is required to study the tibial growth plate involvement for its contribution to the varus / valgus deformity in a chronological method. Further research is also required to quantify the time frame for disease and deformity progression in the Tibiotalar Joint.

scholarly journals Adipose-derived stromal vascular fraction prevent bone bridge formation on growth plate injury in rat (in vivo studies) an experimental research

2020 ◽  
Vol 60 ◽  
pp. 211-217
Author(s):  
Panji Sananta ◽  
Rahaditya I Gede Made Oka ◽  
Prof Respati Suryanto Dradjat ◽  
Heri Suroto ◽  
Edi Mustamsir ◽  
...  
Keyword(s):  
Growth Plate ◽  
Experimental Research ◽  
Stromal Vascular Fraction ◽  
In Vivo Studies ◽  
Bone Bridge ◽  
Bridge Formation ◽  
Growth Plate Injury
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