Characterization of a small animal growth plate injury model using microcomputed tomography

Bone ◽  
2010 ◽  
Vol 46 (6) ◽  
pp. 1555-1563 ◽  
Author(s):  
Rhima M. Coleman ◽  
Jennifer E. Phillips ◽  
Angela Lin ◽  
Zvi Schwartz ◽  
Barbara D. Boyan ◽  
...  
Keyword(s):  
Growth Plate ◽  
Small Animal ◽  
Microcomputed Tomography ◽  
Injury Model ◽  
Animal Growth ◽  
Growth Plate Injury

scholarly journals A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

10.3791/55571 ◽  
2017 ◽  
Author(s):  
Christopher B. Erickson ◽  
Nichole Shaw ◽  
Nancy Hadley-Miller ◽  
Michael S. Riederer ◽  
Melissa D. Krebs ◽  
...  
Keyword(s):  
Growth Plate ◽  
Injury Model ◽  
Repair Mechanisms ◽  
Regeneration Strategies ◽  
Growth Plate Injury ◽  
Tibial Growth Plate

scholarly journals Comparison of mesenchymal stem cell sheets and chondrocyte sheets in a rabbit growth plate injury model

2020 ◽  
Vol 50 (4) ◽  
pp. 1082-1096
Author(s):  
Alper GÜLTEKİN ◽  
Yücel AĞIRDİL ◽  
Büşra Öncel DUMAN ◽  
Cansu Subaşı DEMİR ◽  
Erdal KARAÖZ
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Growth Plate ◽  
Cell Sheets ◽  
Injury Model ◽  
Growth Plate Injury

scholarly journals Local Changes to the Distal Femoral Growth Plate Following Injury in Mice

2017 ◽  
Vol 139 (7) ◽  
Author(s):  
Lauren M. Mangano Drenkard ◽  
Meghan E. Kupratis ◽  
Katie Li ◽  
Louis C. Gerstenfeld ◽  
Elise F. Morgan
Keyword(s):  
Growth Plate ◽  
Skeletal Development ◽  
Global Changes ◽  
Mineral Density ◽  
Injury Site ◽  
Hypertrophic Zone ◽  
Proliferative Zone ◽  
Spatial Changes ◽  
Zonal Organization ◽  
Growth Plate Injury

Injury to the growth plate is associated with growth disturbances, most notably premature cessation of growth. The goal of this study was to identify spatial changes in the structure and composition of the growth plate in response to injury to provide a foundation for developing therapies that minimize the consequences for skeletal development. We used contrast-enhanced microcomputed tomography (CECT) and histological analyses of a murine model of growth plate injury to quantify changes in the cartilaginous and osseous tissue of the growth plate. To distinguish between local and global changes, the growth plate was divided into regions of interest near to and far from the injury site. We noted increased thickness and CECT attenuation (a measure correlated with glycosaminoglycan (GAG) content) near the injury, and increased tissue mineral density (TMD) of bone bridges within the injury site, compared to outside the injury site and contralateral growth plates. Furthermore, we noted disruption of the normal zonal organization of the physis. The height of the hypertrophic zone was increased at the injury site, and the relative height of the proliferative zone was decreased across the entire injured growth plate. These results indicate that growth plate injury leads to localized disruption of cellular activity and of endochondral ossification. These local changes in tissue structure and composition may contribute to the observed retardation in femur growth. In particular, the changes in proliferative and hypertrophic zone heights seen following injury may impact growth and could be targeted when developing therapies for growth plate injury.

scholarly journals Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model

2016 ◽  
Vol 186 (3) ◽  
pp. 524-538 ◽  
Author(s):  
Michelle Melino ◽  
Victoria L. Gadd ◽  
Kylie A. Alexander ◽  
Lynette Beattie ◽  
Katie E. Lineburg ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Injury Model

Dosimetric characterization of an image-guided stereotactic small animal irradiator

2011 ◽  
Vol 56 (8) ◽  
pp. 2585-2599 ◽  
Author(s):  
R Pidikiti ◽  
S Stojadinovic ◽  
M Speiser ◽  
K H Song ◽  
F Hager ◽  
...  
Keyword(s):  
Small Animal ◽  
Image Guided

Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice

2019 ◽  
Vol 98 (2) ◽  
pp. 338-352 ◽  
Author(s):  
Priscila Medeiros ◽  
Renato Leonardo Freitas ◽  
Serena Boccella ◽  
Monica Iannotta ◽  
Carmela Belardo ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Injury Model ◽  
Chronic Constriction Injury Model
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