scholarly journals Convergent synthesis of the tetrasaccharide repeating unit of theO-antigen ofShigella boydiitype 9

2011 ◽  
Vol 7 ◽  
pp. 1182-1188
Author(s):  
Abhishek Santra ◽  
Anup Kumar Misra
Keyword(s):  
Functional Groups ◽  
Selective Oxidation ◽  
Primary Alcohol ◽  
High Yield ◽  
Carboxylic Group ◽  
Convergent Synthesis ◽  
Shigella Boydii ◽  
Excellent Yield ◽  
Convenient Synthesis

A convenient synthesis of the tetrasaccharide repeating unit of theO-antigen ofShigella boydiitype 9 has been achieved in excellent yield using a [2 + 2] block glycosylation strategy. TEMPO-mediated selective oxidation of the primary alcohol of the tetrasaccharide derivative8to the carboxylic group followed by deprotection of the functional groups furnished target tetrasaccharide1as its 4-methoxyphenyl glycoside in high yield.

scholarly journals Convenient synthesis of phosphinecarboxamide and phosphinecarbothioamide by hydrophosphination of isocyanates and isothiocyanates

2020 ◽  
Vol 56 (3) ◽  
pp. 443-445 ◽  
Author(s):  
Masumi Itazaki ◽  
Takanari Matsutani ◽  
Tomoya Nochida ◽  
Toshiyuki Moriuchi ◽  
Hiroshi Nakazawa
Keyword(s):  
Reaction Time ◽  
Functional Group ◽  
High Yield ◽  
Convenient Synthesis

Convenient synthesis of phosphinecarboxamidein by hydrophosphination of isocyanates (and isothiocyanates) was achieved without catalyst and solvent. This system shows shorter reaction time, high yield, and good functional group tolerance.

scholarly journals A Single-Step Synthesis of Azetidine-3-Amines

2020 ◽  
Author(s):  
Brian J Wang ◽  
Matthew Duncton
Keyword(s):  
Functional Groups ◽  
Late Stage ◽  
Single Step ◽  
Secondary Amines ◽  
High Yield ◽  
Primary Amines ◽  
Privileged Structure ◽  
One Step ◽  
Alternative Procedures ◽  
Approved Drugs

<div> <p>The azetidine group is frequently encountered within contemporary medicinal chemistry where it is viewed as a privileged structure. However, the introduction of an azetidine can be synthetically challenging. Herein, a straight-forward one step synthesis of azetidine-3-amines, starting from a bench stable, commercial material is presented. The reaction tolerates functional groups commonly encountered in biological-, medicinal- and agro-chemistry, and proceeds in moderate-to-high yield with secondary amines, and moderate-to-low yield with primary amines. The methodology compares favorably to recent alternative procedures and can be utilized in “any-stage” functionalization, including late-stage azetidinylation of approved drugs and other compounds with pharmacological activity.</p> </div>

Convenient Synthesis of Oxazolo[5,4-h]pyrrolo[4,3,2-de]quino­lones via Hypervalent Iodine Mediated Intramolecular Oxidative Cyclization

Synthesis ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 4517-4522
Author(s):  
Li-Ping Sun ◽  
Chun-Meng Wang ◽  
Sheng-Wei Yang ◽  
Kai-Xiang Tang ◽  
Tian-Hong Gao ◽  
...  
Keyword(s):  
Functional Groups ◽  
Practical Method ◽  
Oxidative Cyclization ◽  
Hypervalent Iodine ◽  
Air Atmosphere ◽  
Convenient Synthesis ◽  
Reaction Proceeds ◽  
Intramolecular Oxidative Cyclization

A convenient and practical method has been developed for the synthesis of substituted oxazolo[5,4-h]pyrrolo[4,3,2-de]quinolones via the intramolecular oxidative cyclization by using PIFA as oxidant and TMSOTf as additive in DCE under an air atmosphere. The reaction proceeds in good yields and has good functional groups tolerance.

scholarly journals Pd/Au Based Catalyst Immobilization in Polymeric Nanofibrous Membranes via Electrospinning for the Selective Oxidation of 5-Hydroxymethylfurfural

Processes ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 45 ◽  
Author(s):  
Danilo Bonincontro ◽  
Francesco Fraschetti ◽  
Claire Squarzoni ◽  
Laura Mazzocchetti ◽  
Emanuele Maccaferri ◽  
...  
Keyword(s):  
Selective Oxidation ◽  
Large Scale ◽  
Catalytic Performance ◽  
High Yield ◽  
Key Factors ◽  
Hydroxymethyl Furfural ◽  
Catalyst Immobilization ◽  
Polymeric Component ◽  
Furandicarboxylic Acid ◽  
Nanofibrous Membranes

Innovative nanofibrous membranes based on Pd/Au catalysts immobilized via electrospinning onto different polymers were engineered and tested in the selective oxidation of 5-(hydroxymethyl)furfural in an aqueous phase. The type of polymer and the method used to insert the active phases in the membrane were demonstrated to have a significant effect on catalytic performance. The hydrophilicity and the glass transition temperature of the polymeric component are key factors for producing active and selective materials. Nylon-based membranes loaded with unsupported metal nanoparticles were demonstrated to be more efficient than polyacrylonitrile-based membranes, displaying good stability and leading to high yield in 2,5-furandicarboxylic acid. These results underline the promising potential of large-scale applications of electrospinning for the preparation of catalytic nanofibrous membranes to be used in processes for the conversion of renewable molecules.

scholarly journals Selective benzylic C–H monooxygenation mediated by iodine oxides

2019 ◽  
Vol 15 ◽  
pp. 602-609
Author(s):  
Kelsey B LaMartina ◽  
Haley K Kuck ◽  
Linda S Oglesbee ◽  
Asma Al-Odaini ◽  
Nicholas C Boaz
Keyword(s):  
Selective Oxidation ◽  
High Yield ◽  
Hypervalent Iodine ◽  
Iodine Species ◽  
Mechanistic Analysis ◽  
Substrate Tolerance ◽  
Iodine Oxides ◽  
Moderate Yield

A method for the selective monooxdiation of secondary benzylic C–H bonds is described using an N-oxyl catalyst and a hypervalent iodine species as a terminal oxidant. Combinations of ammonium iodate and catalytic N-hydroxyphthalimide (NHPI) were shown to be effective in the selective oxidation of n-butylbenzene directly to 1-phenylbutyl acetate in high yield (86%). This method shows moderate substrate tolerance in the oxygenation of substrates containing secondary benzylic C–H bonds, yielding the corresponding benzylic acetates in good to moderate yield. Tertiary benzylic C–H bonds were shown to be unreactive under similar conditions, despite the weaker C–H bond. A preliminary mechanistic analysis suggests that this NHPI-iodate system is functioning by a radical-based mechanism where iodine generated in situ captures formed benzylic radicals. The benzylic iodide intermediate then solvolyzes to yield the product ester.

Selective Oxidation of a Single Primary Alcohol Function in Oligopyridine Frameworks

2004 ◽  
Vol 6 (17) ◽  
pp. 2865-2868 ◽  
Author(s):  
Raymond Ziessel ◽  
Patrick Nguyen ◽  
Laurent Douce ◽  
Michèle Cesario ◽  
Claude Estournes
Keyword(s):  
Selective Oxidation ◽  
Primary Alcohol

Templated high-yield synthesis of Pt nanorods enclosed by high-index {311} facets for methanol selective oxidation

2013 ◽  
Vol 1 (25) ◽  
pp. 7316 ◽  
Author(s):  
Lini Yang ◽  
Xuehua Song ◽  
Menglu Qi ◽  
Lixin Xia ◽  
Mingshang Jin
Keyword(s):  
Selective Oxidation ◽  
High Index ◽  
High Yield ◽  
Methanol Selective Oxidation
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