scholarly journals Smart molecules for imaging, sensing and health (SMITH)

2015 ◽  
Vol 11 ◽  
pp. 2540-2548 ◽  
Author(s):  
Bradley D Smith
Keyword(s):  
Molecular Imaging ◽  
Membrane Transport ◽  
Supramolecular Chemistry ◽  
Ion Pair ◽  
Personal Account ◽  
Future Directions ◽  
Squaraine Rotaxanes

This autobiographical review provides a personal account of the author’s academic journey in supramolecular chemistry, including brief summaries of research efforts in membrane transport, molecular imaging, ion-pair receptors, rotaxane synthesis, squaraine rotaxanes, and synthtavidin technology. The article concludes with a short perspective of likely future directions in biomedical supramolecular chemistry.

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

2012 ◽  
Vol 92 (2) ◽  
pp. 897-965 ◽  
Author(s):  
Michelle L. James ◽  
Sanjiv S. Gambhir
Keyword(s):  
Molecular Imaging ◽  
Small Molecules ◽  
Cell Tracking ◽  
Imaging Techniques ◽  
Imaging Agents ◽  
Future Directions ◽  
Biochemical Processes ◽  
Disease States ◽  
Molecular Imaging Agents ◽  
Clinical Questions

Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In this review, we focus specifically on molecular imaging of intact living subjects. We provide a basic primer for those who are new to molecular imaging, and a resource for those involved in the field. We begin by describing classical molecular imaging techniques together with their key strengths and limitations, after which we introduce some of the latest emerging imaging modalities. We provide an overview of the main classes of molecular imaging agents (i.e., small molecules, peptides, aptamers, engineered proteins, and nanoparticles) and cite examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics (therapy combined with diagnostics). A step-by-step guide to answering biological and/or clinical questions using the tools of molecular imaging is also provided. We conclude by discussing the grand challenges of the field, its future directions, and enormous potential for further impacting how we approach research and medicine.

Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs

2009 ◽  
Vol 137 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Jonathan M. Miller ◽  
Arik Dahan ◽  
Deepak Gupta ◽  
Sheeba Varghese ◽  
Gordon L. Amidon
Keyword(s):  
Membrane Transport ◽  
Ion Pair ◽  
Equilibrium Analysis ◽  
Low Permeability ◽  
Quasi Equilibrium

Practical applications of supramolecular chemistry

2017 ◽  
Vol 46 (9) ◽  
pp. 2385-2390 ◽  
Author(s):  
Igor V. Kolesnichenko ◽  
Eric V. Anslyn
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Supramolecular Chemistry ◽  
Metal Extraction ◽  
Practical Applications

Supramolecular chemistry has branched into many different subfields, finding practical applications in sensing, molecular imaging, metal extraction, and drug delivery.

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