Practical applications of supramolecular chemistry

2017 ◽  
Vol 46 (9) ◽  
pp. 2385-2390 ◽  
Author(s):  
Igor V. Kolesnichenko ◽  
Eric V. Anslyn
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Supramolecular Chemistry ◽  
Metal Extraction ◽  
Practical Applications

Supramolecular chemistry has branched into many different subfields, finding practical applications in sensing, molecular imaging, metal extraction, and drug delivery.

scholarly journals The Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 119
Author(s):  
Simone A.G. Langeveld ◽  
Inés Beekers ◽  
Gonzalo Collado-Lara ◽  
Antonius F. W. van der Steen ◽  
Nico de Jong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
High Speed ◽  
Phase Distribution ◽  
Direct Method ◽  
Ultrasound Contrast Agents ◽  
Lipid Phase ◽  
Acoustic Behavior ◽  
Ultrasound Molecular Imaging ◽  
The Impact

Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the acoustic behavior of microbubbles. Cholesterol was used to modify the lateral molecular packing of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)-based microbubbles. To assess the effect of lipid handling, microbubbles were produced by a direct method, i.e., lipids directly dispersed in an aqueous medium or indirect method, i.e., lipids first dissolved in an organic solvent. The lipid phase and ligand distribution in the microbubble coating were investigated using confocal microscopy, and the acoustic response was recorded with the Brandaris 128 ultra-high-speed camera. In microbubbles with 12 mol% cholesterol, the lipids were miscible and all in the same phase, which resulted in more buckle formation, lower shell elasticity and higher shell viscosity. Indirect DSPC microbubbles had a more uniform response to ultrasound than direct DSPC and indirect DSPC-cholesterol microbubbles. The difference in lipid handling between direct and indirect DSPC microbubbles significantly affected the acoustic behavior. Indirect DSPC microbubbles are the most promising candidate for ultrasound molecular imaging and drug delivery applications.

scholarly journals Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

2019 ◽  
Vol 87 (3) ◽  
pp. 20 ◽  
Author(s):  
Miléna Lengyel ◽  
Nikolett Kállai-Szabó ◽  
Vince Antal ◽  
András József Laki ◽  
István Antal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Freeze Drying ◽  
Delivery Systems ◽  
The Novel ◽  
Practical Applications ◽  
Inhaled Insulin ◽  
Formulation Factors ◽  
Novel Drug ◽  
Significant Production

Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1–1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.

Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications

2013 ◽  
Vol 37 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Eun Hye Jeong ◽  
Giyoung Jung ◽  
Cheol Am Hong ◽  
Hyukjin Lee
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Gold Nanoparticle ◽  
Biomedical Applications

Core-Shell Nanoparticles for Drug Delivery and Molecular Imaging

2007 ◽  
Author(s):  
Sung Kyun Han ◽  
Ree Sun Kim ◽  
Jin Ho Lee ◽  
Giyoong Tae ◽  
Sun Hang Cho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Applications of Nanomaterials for Theranostics of Melanoma

2020 ◽  
Vol 1 (1) ◽  
pp. 39-55
Author(s):  
Guanqiao Jin ◽  
Pohlee Cheah ◽  
Jing Qu ◽  
Lijuan Liu ◽  
Yongfeng Zhao
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Early Diagnosis ◽  
Real Time ◽  
Treatment Plan ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Diagnostic Methods ◽  
Therapeutic Drug

Melanoma is an aggressive form of skin cancer with a very high mortality rate. Early diagnosis of the disease, the utilization of more potent pharmacological agents, and more effective drug delivery systems are essential to achieve an optimal treatment plan. The applications of nanotechnology to improve therapeutic efficacy and early diagnosis for melanoma treatment have received great interest among researchers and clinicians. In this review, we summarize the recent progress of utilizing various nanomaterials for theranostics of melanoma. The key importance of using nanomaterials for theranostics of melanoma is to improve efficacy and reduce side effects, ensuring safe implementation in clinical use. As opposed to conventional in vitro diagnostic methods, in vivo medical imaging technologies have the advantages of being a type of non-invasive, real-time monitoring. Several common nanoparticles, including ultrasmall superparamagnetic iron oxide nanoparticles, silica nanoparticles, and carbon-based nanoparticles, have been applied to deliver chemotherapeutic agents for the theranostics of melanoma. The application of nanomaterials for theranostics in molecular imaging (MRI, PET, US, OI, etc.) plays an important role in targeting drug delivery of melanoma, by monitoring the distribution site of the molecular imaging probe and the therapeutic drug in the body in real-time. Hence, it is worthwhile to anticipate the approval of these nanomaterials for theranostics in molecular imaging by the US Food and Drug Administration in clinical trials.

scholarly journals Lipid-Shelled Vehicles: Engineering for Ultrasound Molecular Imaging and Drug Delivery

2009 ◽  
Vol 42 (7) ◽  
pp. 881-892 ◽  
Author(s):  
Katherine W. Ferrara ◽  
Mark A. Borden ◽  
Hua Zhang
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Ultrasound Molecular Imaging

In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine

Breast Cancer ◽  
2008 ◽  
Vol 15 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Motohiro Takeda ◽  
Hiroshi Tada ◽  
Hideo Higuchi ◽  
Yoshio Kobayashi ◽  
Masaki Kobayashi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Sentinel Node ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Molecular Targeting ◽  
Molecular Targeting Drug

Using Approximate Bayesian Computation to Assess the Reliability of Nanocomponents of a Nanosystem

2016 ◽  
Vol 23 (02) ◽  
pp. 1650009 ◽  
Author(s):  
Nader Ebrahimi ◽  
Kristin McCullough
Keyword(s):  
Drug Delivery ◽  
Design Process ◽  
Approximate Bayesian Computation ◽  
Protective Coatings ◽  
Computational Algorithms ◽  
Bayesian Computation ◽  
Solar Panels ◽  
Practical Applications ◽  
Approximate Bayesian ◽  
Overall Reliability

Nanosystems have great potential in practical applications such as: sensors, circuits, solar panels, super strong materials, protective coatings, and drug delivery. Much research is devoted to designing and fabricating these nanosystems. However, the question of reliability is often overlooked during the design process. Specifically, the ability to analyze the reliability of the nanocomponents is lost. In this paper, we introduce the use of Approximate Bayesian Computation to assess nanocomponent reliability. Data on the lifetime of the nanocomponents is not required with this approach; instead data on the lifetime of the nanosystem is utilized. The proposed statistical and computational algorithms result in a more comprehensible understanding of the nanosystem in order to improve the overall reliability.

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