scholarly journals Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

2014 ◽  
Vol 10 ◽  
pp. 2756-2764 ◽  
Author(s):  
Kayoko Hayashida ◽  
Taishi Higashi ◽  
Daichi Kono ◽  
Keiichi Motoyama ◽  
Koki Wada ◽  
...  
Keyword(s):  
Sustained Release ◽  
Drug Carrier ◽  
Membrane Integrity ◽  
Drug Carriers ◽  
Release Mechanism ◽  
Linear Polymers ◽  
Pegylated Liposome ◽  
Release Drug ◽  
The Matrix ◽  
Preparation And Evaluation

Cyclodextrins (CDs) can form polypseudorotaxanes (PPRXs) with drugs or drug carriers possessing linear polymers such as polyethylene glycol (PEG). On the other hand, PEGylated liposomes have been utilized as a representative anticancer drug carrier. However, little is known about the formation of CD PPRX with PEGylated liposome. In the present study, we first report the formation of CD PPRX with PEGylated liposome and evaluate it as a sustained release drug carrier. PEGylated liposome encapsulating doxorubicin was disrupted by the addition of α-CD. Meanwhile, γ-CD included two PEG chains and/or one bending PEG chain of PEGylated liposome and formed PPRX without the disruption of the membrane integrity of the PEGylated liposome. Moreover, the release of doxorubicin and/or PEGylated liposome encapsulating doxorubicin from the PPRX was prolonged in accordance with the matrix type release mechanism. These findings suggest the potential of γ-CD PPRX as sustained release carriers for PEGylated liposome products.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

scholarly journals Study on montmorillonite–chlorhexidine acetate–terbinafine hydrochloride intercalation composites as drug release systems

RSC Advances ◽  
2018 ◽  
Vol 8 (38) ◽  
pp. 21369-21377 ◽  
Author(s):  
Baohong Sun ◽  
Ming Zhang ◽  
Ninglin Zhou ◽  
Xiaohong Chu ◽  
Ping Yuan ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Drug Carriers ◽  
Terbinafine Hydrochloride ◽  
Release Drug

This paper focuses on the intercalation of chlorhexidine acetate (CA) and terbinafine hydrochloride (TBH) into montmorillonite as sustained release drug carriers.

Coatless alginate pellets as sustained-release drug carrier for inflammatory bowel disease treatment

2016 ◽  
Vol 152 ◽  
pp. 370-381 ◽  
Author(s):  
Siti Hajar Md Ramli ◽  
Tin Wui Wong ◽  
Idanawati Naharudin ◽  
Anirbandeep Bose
Keyword(s):  
Inflammatory Bowel Disease ◽  
Sustained Release ◽  
Bowel Disease ◽  
Drug Carrier ◽  
Disease Treatment ◽  
Release Drug ◽  
Inflammatory Bowel

Chitosan and chitosan/β-cyclodextrin microspheres as sustained-release drug carriers

2006 ◽  
Vol 103 (2) ◽  
pp. 1183-1190 ◽  
Author(s):  
Wei Fen Zhang ◽  
Xi Guang Chen ◽  
Pi Wu Li ◽  
Qiang Zhi He ◽  
Hui Yun Zhou
Keyword(s):  
Sustained Release ◽  
Drug Carriers ◽  
Release Drug

Chitosan sponges as sustained release drug carriers

1997 ◽  
Vol 156 (2) ◽  
pp. 229-237 ◽  
Author(s):  
Kwunchit Oungbho ◽  
Bernd W Müller
Keyword(s):  
Sustained Release ◽  
Drug Carriers ◽  
Release Drug

scholarly journals SALICYLIC ACID INCORPORATION IN Fe3O4-BSA NANOPARTICLES FOR DRUG RELEASE

Química Nova ◽  
2021 ◽  
Author(s):  
Renata Neves ◽  
Erika Bronze-Uhle ◽  
Pâmela Santos ◽  
Paulo Lisboa-Filho ◽  
Aroldo Magdalena
Keyword(s):  
Salicylic Acid ◽  
Controlled Release ◽  
Colloidal Stability ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Release Mechanism ◽  
The Matrix ◽  
Collateral Effects ◽  
Average Size

The controlled release of Salicylic Acid (SA) influences the concentration and collateral effects of the drug. This release refers to the matrix in which the SA is incorporated. Among the matrices, Fe3O4 nanoparticles (NPs) stand out, for transporting drugs to specific sites. The functionalization of Fe3O4 by bovine serum albumin (BSA) can improve colloidal and chemical stability, in addition to increasing interactions with drugs. Thus, understanding the release kinetics of the AS incorporated in Fe3O4-BSA is essential to improve the controlled release. The study aimed the synthesis, characterization and release of the SA into the Fe3O4-BSA NPs. The results showed the functionalization of the Fe3O4-BSA NPs was effective and the average size was below 30 nm. The NPs showed colloidal stability above the pH of 7.5 which can be used as a drug carrier in blood plasma. Drug encapsulation into the NPs system was efficient (~91%) with about 30% of drug loading capability. The kinetic results showed the SA release mechanism was controlled by diffusion. The conclusion is that the incorporation of SA in Fe3O4-BSA NPs led to a release of SA in the first six hours, reaching equilibrium at 0.265 mg mL-1 and 1.83 mg.

scholarly journals Thermosensitive star polymer pompons with a core–arm structure as thermo-responsive controlled release drug carriers

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15604-15612 ◽  
Author(s):  
Na Xu ◽  
Xiaobei Huang ◽  
Guangfu Yin ◽  
Meijiao Bu ◽  
Ximing Pu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Star Polymer ◽  
Release Drug

Herein, a thermosensitive star polymer pompon with a core–arm structure was synthesized using a grafting-on method as a thermo-responsive controlled release drug carrier.

scholarly journals New Alginate/PNIPAAm Matrices for Drug Delivery

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 366 ◽  
Author(s):  
Catalina Cheaburu-Yilmaz ◽  
Catalina Lupuşoru ◽  
Cornelia Vasile
Keyword(s):  
Graft Copolymer ◽  
Near Infrared ◽  
Graft Copolymers ◽  
Drug Carrier ◽  
Chemical Imaging ◽  
Release Mechanism ◽  
Prolonged Release ◽  
The Matrix

This paper deals with a comparative study on the interpolymeric complexes of alginate poly(N-isopropyl acryl amide (PNIPAAm) and corresponding graft copolymers with various compositions in respect to their toxicity, biocompatibility and in vitro and in vivo release of theophylline (THP). Loading of the various matrices with theophylline and characterization of loaded matrices was studied by near infrared spectroscopy–chemical imaging (NIR–CI) analysis, scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). It was appreciated that THP loading is higher than 40% and the drug is relatively homogeneous distributed within all matrices because of some specific interactions between components of the system. All samples have been found to be non-toxic and biocompatible. It was established that graft copolymers having a good stability show a better drug carrier ability, a higher THP loading, a prolonged release (longer release duration for graft copolymers of 235.4–302.3 min than that for IPC 72/28 of 77.6 min, which means approximately four times slower release from the graft copolymer-based matrices than from the interpolymeric complex) and a good bioavailability. The highest values for THP loading (45%), prolonged release (302.3 min) and bioavailability (175%) were obtained for graft copolymer AgA-g-PNIPAAm 68. The drug release mechanism varies with composition and architecture of the matrix.

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