Chitosan and chitosan/β-cyclodextrin microspheres as sustained-release drug carriers

2006 ◽  
Vol 103 (2) ◽  
pp. 1183-1190 ◽  
Author(s):  
Wei Fen Zhang ◽  
Xi Guang Chen ◽  
Pi Wu Li ◽  
Qiang Zhi He ◽  
Hui Yun Zhou
Keyword(s):  
Sustained Release ◽  
Drug Carriers ◽  
Release Drug

scholarly journals Study on montmorillonite–chlorhexidine acetate–terbinafine hydrochloride intercalation composites as drug release systems

RSC Advances ◽  
2018 ◽  
Vol 8 (38) ◽  
pp. 21369-21377 ◽  
Author(s):  
Baohong Sun ◽  
Ming Zhang ◽  
Ninglin Zhou ◽  
Xiaohong Chu ◽  
Ping Yuan ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Drug Carriers ◽  
Terbinafine Hydrochloride ◽  
Release Drug

This paper focuses on the intercalation of chlorhexidine acetate (CA) and terbinafine hydrochloride (TBH) into montmorillonite as sustained release drug carriers.

Chitosan sponges as sustained release drug carriers

1997 ◽  
Vol 156 (2) ◽  
pp. 229-237 ◽  
Author(s):  
Kwunchit Oungbho ◽  
Bernd W Müller
Keyword(s):  
Sustained Release ◽  
Drug Carriers ◽  
Release Drug

scholarly journals Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

2014 ◽  
Vol 10 ◽  
pp. 2756-2764 ◽  
Author(s):  
Kayoko Hayashida ◽  
Taishi Higashi ◽  
Daichi Kono ◽  
Keiichi Motoyama ◽  
Koki Wada ◽  
...  
Keyword(s):  
Sustained Release ◽  
Drug Carrier ◽  
Membrane Integrity ◽  
Drug Carriers ◽  
Release Mechanism ◽  
Linear Polymers ◽  
Pegylated Liposome ◽  
Release Drug ◽  
The Matrix ◽  
Preparation And Evaluation

Cyclodextrins (CDs) can form polypseudorotaxanes (PPRXs) with drugs or drug carriers possessing linear polymers such as polyethylene glycol (PEG). On the other hand, PEGylated liposomes have been utilized as a representative anticancer drug carrier. However, little is known about the formation of CD PPRX with PEGylated liposome. In the present study, we first report the formation of CD PPRX with PEGylated liposome and evaluate it as a sustained release drug carrier. PEGylated liposome encapsulating doxorubicin was disrupted by the addition of α-CD. Meanwhile, γ-CD included two PEG chains and/or one bending PEG chain of PEGylated liposome and formed PPRX without the disruption of the membrane integrity of the PEGylated liposome. Moreover, the release of doxorubicin and/or PEGylated liposome encapsulating doxorubicin from the PPRX was prolonged in accordance with the matrix type release mechanism. These findings suggest the potential of γ-CD PPRX as sustained release carriers for PEGylated liposome products.

Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

scholarly journals Recent advances in intraocular sustained-release drug delivery devices

2019 ◽  
Vol 24 (8) ◽  
pp. 1694-1700 ◽  
Author(s):  
Yiqi Cao ◽  
Karen E. Samy ◽  
Daniel A. Bernards ◽  
Tejal A. Desai
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Release Drug ◽  
Recent Advances ◽  
Drug Delivery Devices
Sign in / Sign up

Export Citation Format

Share Document