Effects of Chinese herbal medicine Feiyanning Decoction on the ratio of CD4+CD25+ regulatory T cells and expression of transcription factor Foxp3 in mice bearing Lewis lung carcinoma

2012 ◽  
Vol 10 (5) ◽  
pp. 584-590 ◽  
Author(s):  
J Guo
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Herbal Medicine ◽  
Regulatory T Cells ◽  
Lung Carcinoma ◽  
Chinese Herbal Medicine ◽  
Lewis Lung Carcinoma ◽  
Lewis Lung ◽  
Chinese Herbal

scholarly journals P3.02c-071 Spatially Selective Depletion of Regulatory T Cells with near Infrared Photoimmunotherapy for Syngeneic Lewis Lung Carcinoma

2017 ◽  
Vol 12 (1) ◽  
pp. S1319-S1320
Author(s):  
Kazuhide Sato ◽  
Noriko Sato ◽  
Biying Xu ◽  
Peter Choyke ◽  
Yoshinori Hasegawa ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Near Infrared ◽  
Lewis Lung ◽  
Selective Depletion

scholarly journals Yifei Tongluo, a Chinese Herbal Formula, Suppresses Tumor Growth and Metastasis and Exerts Immunomodulatory Effect in Lewis Lung Carcinoma Mice

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 731
Author(s):  
Qiuchen Qi ◽  
Yanhong Hou ◽  
Ang Li ◽  
Yueyue Sun ◽  
Siying Li ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Herbal Formula ◽  
Lewis Lung ◽  
Mesenchymal Transition ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Tumor Bearing ◽  
Model Control

This study was aimed to investigate the anti-tumor, anti-metastasis and immunomodulatory effects of Yifei Tongluo (YFTL), a Chinese herbal formula, in Lewis lung carcinoma mice and to explore the underlying mechanisms. LLC cells were inoculated subcutaneously in C57BL/6 mice to establish the Lewis lung carcinoma model. We observed that YFTL effectively inhibited tumor growth and prolonged the overall survival of tumor-bearing mice. Additionally, YFTL treatment resulted in a significantly decreased number of surface lung metastatic lesions compared with the model control group. Meanwhile, TUNEL staining confirmed that the tumors from YFTL-treated mice exhibited a markedly higher apoptotic index. The results suggest that Akt and mitogen-activated protein kinase (MAPKs) pathways may be involved in YFTL-induced apoptosis. The results show that YFTL also inhibited the vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMP)-2, MMP-9, N-cadherin, and Vimentin expression, but increased E-cadherin expression. Mechanistic studies indicated that YFTL could suppress the angiogenesis and the epithelial-mesenchymal transition (EMT) of the tumor through Akt/ERK1/2 and TGFβ1/Smad2 pathways. In addition, YFTL also showed immunomodulatory activities in improving the immunosuppressive state of tumor-bearing mice. Therefore, our findings could support the development of YFTL as a potential antineoplastic agent and a potentially useful anti-metastatic agent for lung carcinoma therapy.

scholarly journals Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

2020 ◽  
Vol 11 ◽  
Author(s):  
Robert D. Hoffman ◽  
Chang-Yu Li ◽  
Kai He ◽  
Xiaoxing Wu ◽  
Bai-Cheng He ◽  
...  
Keyword(s):  
T Cells ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Regulatory Effects

Immunomodulation of T cells by the Chinese herbal medicine Ling Zhi (Ganoderma lucidum)

2003 ◽  
Vol 111 (2) ◽  
pp. S320 ◽  
Author(s):  
M. Wen ◽  
A. Teper ◽  
K.D. Srivastava ◽  
C. Huang ◽  
B. Schofield ◽  
...  
Keyword(s):  
T Cells ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Ganoderma Lucidum ◽  
Chinese Herbal

scholarly journals Intranasal Administration of Codium fragile Polysaccharide Elicits Anti-Cancer Immunity against Lewis Lung Carcinoma

2021 ◽  
Vol 22 (19) ◽  
pp. 10608
Author(s):  
Yuhua Wang ◽  
Eun-Koung An ◽  
So-Jung Kim ◽  
SangGuan You ◽  
Jun-O Jin
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
Lung Carcinoma ◽  
Intranasal Administration ◽  
Lewis Lung Carcinoma ◽  
Mediastinal Lymph Node ◽  
Lavage Fluid ◽  
Lewis Lung ◽  
Codium Fragile ◽  
Lung Carcinoma Cells

Natural polysaccharides have shown promising effects on the regulation of immunity in animals. In this study, we examined the immune stimulatory effect of intranasally administered Codium fragile polysaccharides (CFPs) in mice. Intranasal administration of CFPs in C57BL/6 mice induced the upregulation of surface activation marker expression in macrophages and dendritic cells (DCs) in the mediastinal lymph node (mLN) and the production of interleukin-6 (IL-6), IL-12p70, and tumor necrosis factor-α in bronchoalveolar lavage fluid. Moreover, the number of conventional DCs (cDCs) was increased in the mLNs by the upregulation of C-C motif chemokine receptor 7 expression, and subsets of cDCs were also activated following the intranasal administration of CFP. In addition, the intranasal administration of CFPs promoted the activation of natural killer (NK) and T cells in the mLNs, which produce pro-inflammatory cytokines and cytotoxic mediators. Finally, daily administration of CFPs inhibited the infiltration of Lewis lung carcinoma cells into the lungs, and the preventive effect of CFPs on tumor growth required NK and CD8 T cells. Furthermore, CFPs combined with anti-programmed cell death-ligand 1 (PD-L1) antibody (Ab) improved the therapeutic effect of anti-PD-L1 Ab against lung cancer. Therefore, these data demonstrated that the intranasal administration of CFP induced mucosal immunity against lung cancer.

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