Effect of Z-100, an immunomodulator extracted from human type tubercle bacilli, on the pulmonary metastases of lewis lung carcinoma in attempt to regulate suppressor T cells and suppressor factor, IL-4

Biotherapy ◽  
1996 ◽  
Vol 9 (4) ◽  
pp. 249-255 ◽  
Author(s):  
Yutaka Emori ◽  
Hidetaka Sasaki ◽  
Yoshiro Hayashi ◽  
Kikuo Nomoto
Keyword(s):  
T Cells ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Pulmonary Metastases ◽  
Lewis Lung ◽  
Suppressor T Cells ◽  
Suppressor Factor ◽  
Human Type

Reduced pulmonary metastases of lewis lung carcinoma in hPAI-1 transgenic mice

1994 ◽  
Vol 8 ◽  
pp. 102 ◽  
Author(s):  
A. Poggi ◽  
E. Bellelli ◽  
L. Salvatore ◽  
M.P. Castelli ◽  
R. Marinacci ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Pulmonary Metastases ◽  
Lewis Lung

scholarly journals Intranasal Administration of Codium fragile Polysaccharide Elicits Anti-Cancer Immunity against Lewis Lung Carcinoma

2021 ◽  
Vol 22 (19) ◽  
pp. 10608
Author(s):  
Yuhua Wang ◽  
Eun-Koung An ◽  
So-Jung Kim ◽  
SangGuan You ◽  
Jun-O Jin
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
Lung Carcinoma ◽  
Intranasal Administration ◽  
Lewis Lung Carcinoma ◽  
Mediastinal Lymph Node ◽  
Lavage Fluid ◽  
Lewis Lung ◽  
Codium Fragile ◽  
Lung Carcinoma Cells

Natural polysaccharides have shown promising effects on the regulation of immunity in animals. In this study, we examined the immune stimulatory effect of intranasally administered Codium fragile polysaccharides (CFPs) in mice. Intranasal administration of CFPs in C57BL/6 mice induced the upregulation of surface activation marker expression in macrophages and dendritic cells (DCs) in the mediastinal lymph node (mLN) and the production of interleukin-6 (IL-6), IL-12p70, and tumor necrosis factor-α in bronchoalveolar lavage fluid. Moreover, the number of conventional DCs (cDCs) was increased in the mLNs by the upregulation of C-C motif chemokine receptor 7 expression, and subsets of cDCs were also activated following the intranasal administration of CFP. In addition, the intranasal administration of CFPs promoted the activation of natural killer (NK) and T cells in the mLNs, which produce pro-inflammatory cytokines and cytotoxic mediators. Finally, daily administration of CFPs inhibited the infiltration of Lewis lung carcinoma cells into the lungs, and the preventive effect of CFPs on tumor growth required NK and CD8 T cells. Furthermore, CFPs combined with anti-programmed cell death-ligand 1 (PD-L1) antibody (Ab) improved the therapeutic effect of anti-PD-L1 Ab against lung cancer. Therefore, these data demonstrated that the intranasal administration of CFP induced mucosal immunity against lung cancer.

scholarly journals P3.02c-071 Spatially Selective Depletion of Regulatory T Cells with near Infrared Photoimmunotherapy for Syngeneic Lewis Lung Carcinoma

2017 ◽  
Vol 12 (1) ◽  
pp. S1319-S1320
Author(s):  
Kazuhide Sato ◽  
Noriko Sato ◽  
Biying Xu ◽  
Peter Choyke ◽  
Yoshinori Hasegawa ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Near Infrared ◽  
Lewis Lung ◽  
Selective Depletion
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