scholarly journals Residue Mutations in Murine Herpesvirus 68 Immunomodulatory Protein M3 Reveal Specific Modulation of Chemokine Binding

2020 ◽  
Author(s):  
Radka Šebová ◽  
Vladena Bauerová-Hlinková ◽  
Konrad Beck ◽  
Ivana Nemčovičová ◽  
Jacob Bauer ◽  
...  
Keyword(s):  
Immunomodulatory Protein

scholarly journals Serum protein profiling reveals a specific upregulation of the immunomodulatory protein progranulin in COVID-19

2020 ◽  
Author(s):  
Marina Rieder ◽  
Luisa Wirth ◽  
Luisa Pollmeier ◽  
Maren Jeserich ◽  
Isabella Goller ◽  
...  
Keyword(s):  
Serum Protein ◽  
Interleukin 6 ◽  
Expression Profiles ◽  
Negative Control ◽  
Adverse Outcomes ◽  
Protein Profiling ◽  
Interferon Signaling ◽  
Virus Elimination ◽  
Immunomodulatory Protein ◽  
Viral Responses

Abstract Background Severe courses of COVID-19 are associated with elevated levels of interleukin 6. However, there is a growing body of evidence pointing to a broad and more complex disorder of pro-inflammatory and anti-viral responses with disturbed interferon signaling in COVID-19. Methods In this prospective single-center registry, we included SARS-CoV-2 positive patients and patients with similar symptoms and severity of disease but negative for SARS-CoV-2 admitted to the emergency department and compared their serum protein expression profiles. Results Interleukin-6 abundance was similar in SARS-CoV-2 positive patients (n = 24) compared to SARS-CoV-2 negative control (n = 61). In contrast, we observed a specific upregulation of the immunomodulatory protein progranulin (GRN). High GRN abundance was associated with adverse outcomes and increased expression of interleukin-6 in COVID-19. Conclusion The data from this registry reveals that GRN is specifically upregulated in SARS-CoV-2 positive patients while interleukin-6 may serve as marker for disease severity. The potential of GRN as a biomarker and a possible impact of increased GRN expression on interferon signaling, virus elimination, and virus-induced lung tissue damage in COVID-19 should be further explored.

Effect and mechanism of a novel Cordyceps militaris immunomodulatory protein on the differentiation of macrophages

2021 ◽  
pp. 101268
Author(s):  
Hong-Bo Fan ◽  
Qian-Wang Zheng ◽  
Qing Han ◽  
Yuan Zou ◽  
Ying-Li Liu ◽  
...  
Keyword(s):  
Cordyceps Militaris ◽  
Immunomodulatory Protein

N-Glycosylated Ganoderma lucidum immunomodulatory protein improved anti-inflammatory activity via inhibition of the p38 MAPK pathway

2021 ◽  
Vol 12 (8) ◽  
pp. 3393-3404
Author(s):  
Qi-Zhang Li ◽  
Xin Chen ◽  
Pei-Wen Mao ◽  
Meng-Yuan Jin ◽  
Qin Wu ◽  
...  
Keyword(s):  
Global Health ◽  
P38 Mapk ◽  
Ganoderma Lucidum ◽  
Mapk Pathway ◽  
Inflammatory Activity ◽  
Immunomodulatory Agents ◽  
P38 Mapk Pathway ◽  
Immunomodulatory Protein ◽  
Anti Inflammatory

The global health emergency generated by coronavirus disease-2019 has prompted the search for immunomodulatory agents.

scholarly journals In Silico and In Vitro Studies on the Protein-Protein Interactions between Brugia malayi Immunomodulatory Protein Calreticulin and Human C1q

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106413 ◽  
Author(s):  
Sunita Yadav ◽  
Smita Gupta ◽  
Chandrabose Selvaraj ◽  
Pawan Kumar Doharey ◽  
Anita Verma ◽  
...  
Keyword(s):  
Protein Interactions ◽  
In Silico ◽  
Brugia Malayi ◽  
In Vitro Studies ◽  
Protein Protein Interactions ◽  
Immunomodulatory Protein

scholarly journals Identification of a Parasitic Immunomodulatory Protein Triggering the Development of Suppressive M1 Macrophages during African Trypanosomiasis

2009 ◽  
Vol 200 (12) ◽  
pp. 1849-1860 ◽  
Author(s):  
Julio Gómez‐Rodríguez ◽  
Benoit Stijlemans ◽  
Géraldine De Muylder ◽  
Hannelie Korf ◽  
Lea Brys ◽  
...  
Keyword(s):  
African Trypanosomiasis ◽  
M1 Macrophages ◽  
Immunomodulatory Protein
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