scholarly journals Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia

2020 ◽  
Vol 11 ◽  
Author(s):  
Xinhua Lei ◽  
Chenyang Zhi ◽  
Wei Huang ◽  
Xilin Sun ◽  
Weiyang Gao ◽  
...  
Keyword(s):  
Ganoderma Lucidum ◽  
Chemotherapy Induced Neutropenia ◽  
Immunomodulatory Protein

N-Glycosylated Ganoderma lucidum immunomodulatory protein improved anti-inflammatory activity via inhibition of the p38 MAPK pathway

2021 ◽  
Vol 12 (8) ◽  
pp. 3393-3404
Author(s):  
Qi-Zhang Li ◽  
Xin Chen ◽  
Pei-Wen Mao ◽  
Meng-Yuan Jin ◽  
Qin Wu ◽  
...  
Keyword(s):  
Global Health ◽  
P38 Mapk ◽  
Ganoderma Lucidum ◽  
Mapk Pathway ◽  
Inflammatory Activity ◽  
Immunomodulatory Agents ◽  
P38 Mapk Pathway ◽  
Immunomodulatory Protein ◽  
Anti Inflammatory

The global health emergency generated by coronavirus disease-2019 has prompted the search for immunomodulatory agents.

scholarly journals Recombinant Ganoderma lucidum immunomodulatory protein modified with polyethylene glycol

2013 ◽  
Vol 7 (3) ◽  
pp. 975-980 ◽  
Author(s):  
XIPING ZHANG ◽  
FEI SUN ◽  
ZHIYI LIU ◽  
SHUQIN ZHANG ◽  
CHONGYANG LIANG
Keyword(s):  
Polyethylene Glycol ◽  
Ganoderma Lucidum ◽  
Immunomodulatory Protein

scholarly journals Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in macrophage RAW264.7 cells

2018 ◽  
Author(s):  
Xuanwei Zhou ◽  
Qizhang Li ◽  
Yuzhou Chang ◽  
Liu-Ding-Ji Li ◽  
Xiaoyu Du ◽  
...  
Keyword(s):  
Ganoderma Lucidum ◽  
Kinase Inhibitor ◽  
Mapk Signaling ◽  
Raw264.7 Cells ◽  
In Vitro Assays ◽  
Immunomodulatory Activity ◽  
Inos Mrna ◽  
Sequencing Analysis ◽  
Mrna Levels ◽  
Immunomodulatory Protein

Ganoderma lucidum, a traditional edible and medicinal fungus, holds an important status in health care systems in China and other Asian countries. Fungal immunomodulatory protein (FIP), one of the active ingredients isolated from G. lucidum, is a class of naturally occurring proteins and possesses potential biological functions. This study was conducted to explore the molecular mechanism of its immunomodulatory potency in immune responses of macrophages. In vitro assays of biological activity indicated that rFIP-glu significantly activated macrophage RAW264.7 cells, and possessed the ability of pro- and anti-inflammation the cells. RNA sequencing analysis showed that macrophage activation involved Toll-like receptors and mitogen-activated protein kinases pathways. Furthermore, qRT-PCR indicated that phosphoinositide 3 kinase inhibitor LY294002 blocked the mRNA levels of MCP-1, MEK1/2 inhibitor U0126 reduced the mRNA levels of TNF-α and MCP-1, and JNK inhibitor SP600125 prevented the up-regulation of iNOS mRNA in the rFIP-glu-induced cells. FIP-glu mediated these inflammatory effects not through a general pathway, instead through a different pathway for different inflammatory mediator. These data indicate the possibility that rFIP-glu has an important immune-regulation function and thus has potential therapeutic uses.

scholarly journals Molecular cloning of a cDNA and a gene encoding an immunomodulatory protein, Ling Zhi-8, from a fungus, Ganoderma lucidum

1991 ◽  
Vol 266 (4) ◽  
pp. 2486-2493
Author(s):  
A Murasugi ◽  
S Tanaka ◽  
N Komiyama ◽  
N Iwata ◽  
K Kino ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Ganoderma Lucidum ◽  
Gene Encoding ◽  
Immunomodulatory Protein
Sign in / Sign up

Export Citation Format

Share Document