scholarly journals THE ROLE OF THE KIDNEYS IN THE REGULATION OF THE ACID – BASE BALANCE OF THE BLOOD IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2021 ◽  
Vol 74 (2) ◽  
pp. 288-290
Author(s):  
Oksana V. Veremiienko ◽  
Tatyana S. Ospanova ◽  
Zhanna D. Semydotska
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Acid Base Balance ◽  
Acid Base ◽  
Obstructive Pulmonary Disease ◽  
Excretory Function ◽  
Base Balance ◽  
Group B ◽  
Renal Excretory Function

The aim: To study the regulation of acid-base balance and blood acid – renal excretory function in patients with COPD. Materials and methods: We examined 82 people, suggests that even during the most severe stages of COPD. Group 1 included 56 patients with COPD, group C. The average age was 60.54 + 2.04 years old, including 24 men and 32 women. The second group included 16 patients with COPD, group B, whose average age was 55.37 + 3.21 years old, including 7 men and 9 women. The third group included 10 healthy individuals, with an average age of 34.30 + 2.21 years, including 6 men and 4 women. Respiration function was evaluated on the basis of the forced expiratory curve recorded on a Spirolab II MIR S / N computer spirograph. The following indicators were evaluated: forced vital capacity (FVC), forced expiratory volume (FEV1) and FEV1 / FVC ratio. Results: For all patients with COPD there is a characteristic presence of acidosis (pH in patients with COPD group B – 7,34 ± 0,01, in patients with COPD group C – 7,31 ± 0,07). For patients with COPD group C there are pronounced respiratory disorders (pCO2 – 48,25 + 1,14 mm Hg, p02 – 28.07 +1.37 mm Hg). For patients with COPD group B characteristic metabolic disorders (BE--3,71 + 0,57), which increase as the disease progresses. For patients with COPD group C this figure is equal to 7.62 + 0.49. Thus, the analysis of indicators indicates the presence for all patients of mixed (respiratory and metabolic) acidosis, which increases as the chronic obstructive pulmonary disease progresses. Conclusions: There is activation of acid – renal excretory function and the inclusion of renal mechanisms in the regulation of acid-base balance.

Acid-Base Balance and Oxygen Tension During Dialysis in Uremic Patients With Chronic Obstructive Pulmonary Disease

2008 ◽  
Vol 32 (12) ◽  
pp. 973-977 ◽  
Author(s):  
Simone Manca-Di-Villahermosa ◽  
Michela Tedesco ◽  
Maurizio Lonzi ◽  
Francesca R. Della-Rovere ◽  
Anna Innocenzi ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Oxygen Tension ◽  
Chronic Obstructive ◽  
Acid Base Balance ◽  
Acid Base ◽  
Obstructive Pulmonary Disease ◽  
Base Balance ◽  
Uremic Patients

scholarly journals Рhysiotherapy in Patients with Chronic Obstructive Pulmonary Disease

2017 ◽  
Vol 5 (6) ◽  
pp. 720-723 ◽  
Author(s):  
Antoaneta Dimitrova ◽  
Nikolay Izov ◽  
Ivan Maznev ◽  
Danche Vasileva ◽  
Milena Nikolova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Therapy Program ◽  
Group A ◽  
Severity Of The Disease ◽  
Group B ◽  
Positive Effect

BACKGROUND: Physiotherapy is an essential for the treatment of patients with chronic respiratory non-inflammatory diseases especially for chronic obstructive pulmonary disease (COPD).AIM: To assess the effect of six months physiotherapy (PT) program on functional status in patients with COPD.МАTERIAL AND METHODS: The patients were divided into two groups according to the severity of the disease. Group A included 33 patients (mean age 68.6 ± 7.3; GOLD II – III stages). Group B included 32 patients (mean age 71.7 ± 6.9; GOLD I –II). They were referred to supervised PT program performed three times weekly for a half a year. All the patients were on standard medical care. At entry and after PT, six minutes walking test (6 MWT), Borg scale and modified Medical Research Council (mMRC) scale were assessed.RESULTS: Significant changes in 6 MWT (р < 0.001) and mMRC scale (р < 0.001) were found after applied physical therapy program in patients of group A. Exertional dyspnoea decreased significantly in patients with group A (р < 0.001). Positive changes were found in physical tolerance in the patients of group B (р < 0.001).CONCLUSIONS: The present study revealed the positive effect of six months physiotherapy in physical tolerance and dyspnoea in patients with COPD at different stages of the disease.

scholarly journals Neuromuscular electrostimulation as an adjuvant therapy to pulmonary rehabilitation programs in chronic obstructive pulmonary disease

2020 ◽  
pp. 80-84
Author(s):  
Daniel TRĂILĂ ◽  
Camelia PESCARU ◽  
Noemi SUPPINI POROJAN ◽  
Camil MIHUTA ◽  
Patricia HOGEA ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Muscle Mass ◽  
Pulmonary Rehabilitation ◽  
Rehabilitation Program ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lower Extremity Muscle ◽  
Group B ◽  
Neuromuscular Electrostimulation

Introduction. Chronic obstructive pulmonary disease (COPD) is commonly associated with a vicious circle of sedentary lifestyle - deconditioning - muscular dysfunction. High-frequency neuromuscular electrostimulation has demonstrated beneficial effects among subjects with muscle weakness. This study aimed to evaluate the benefits of merging pulmonary rehabilitation program (PRP) with neuromuscular electrostimulation in patients with very severe COPD. Material and methods. The study included 38 males with clinically stable COPD, who were divided in 2 groups: group A-19 patients that underwent a PRP of 5 sessions/week for 4 weeks and group B-19 patients that underwent intercostal and lower extremity muscle electrostimulation (5 sessions/week for 4 weeks, 60 min /session) in association with the same type of PRP. Saint Georges’s Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) dyspnea scale, spirometry, maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax), six minutes walking test (6MWT) and bio-electrical impedance were examined before and after the intervention. Results. Electrostimulation applied in group B increased muscle mass (50.15 ± 0.61kg vs 53.97 ± 0.87kg, p<0.001)., PEmax (5.41 ± 0.25 vs post 6.79 ± 0.22, p<0.0003) and improved mMRC score (2.68 ± 0.15 vs 2.10 ± 0.15, p<0.0109), 6MWT (369.6 ± 10.77m vs post: 445.6 ± 6.03 m) and SGRQ (61.32 ± 1.83 vs. 44.95 ± 1.94, p<0.0001). In group B only SGRQ score (55.05 ± 1.32 vs. 50.05 ± 1.51, p=0.018) was improved after PRP. Conclusion. A protocol which combines PRP with neuromuscular electrical stimulation in patients with very severe forms of COPD, has grater beneficial effect on dyspnoea, exercise tolerance, muscle mass toning and quality of life, compared with PRP alone.

scholarly journals A CLINICAL STUDY ON SAFETY AND EFFICACY OF FORMOTEROL AND TIOTROPIUM COMBINATION COMPARED TO FORMOTEROL AND TIOTROPIUM WITH ROFLUMILAST COMBINATION IN TREATMENT OF MODERATE TO SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

2018 ◽  
Vol 11 (3) ◽  
pp. 184 ◽  
Author(s):  
Kavitha Devi M ◽  
Sarumathy S ◽  
Sarath Lal Sasidharan ◽  
Sarumathy S ◽  
Mehanaz Shaik ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Comorbid Condition ◽  
Obstructive Pulmonary Disease ◽  
Safety And Efficacy ◽  
Copd Patients ◽  
Before And After ◽  
Study Population ◽  
Group B

 Objectives: The objective of this study is to assess the safety and efficacy of formoterol and tiotropium combination compared to formoterol and tiotropium with roflumilast combination in treatment of moderate-to-severe chronic obstructive pulmonary disease (COPD) patients on inhaled combination therapy. Methods: A comparative prospective interventional study was carried out in 61 COPD patients who were visiting the pulmonary medicine ward during 6 months (October 2016 to March 2017). The patients were randomized into two groups. Group A patients received a combination of formoterol and tiotropium, whereas Group B patients received roflumilast along with formoterol and tiotropium combination. Spirometry tests were done to both the study population. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were noted at the initial visit and after the treatment. All the statistical analyses such as mean and p values were calculated using SPSS 14.0 version software. Results: The average age group of the study population was 57.63±8.3 years. Comorbid condition such as diabetes mellitus was higher in the study groups. Comparison of spirometry reports before and after drug administration in both groups was done. FEV1 and FVC were found to be statistically significant between the study group (0.001, p<0.05).The average mean change of FEV1 before and after treatment in Group B was found to be improved as compared to Group B (0.66). Conclusion: Tiotropium and formoterol with roflumilast combination were found to be safe and effective in moderate-to-severe COPD patients.

scholarly journals Influence of microcirculatory disorders in patients with moderate chronic obstructive pulmonary disease and systemic arterial hypertension on acid-base and gas balance of blood.

2018 ◽  
Vol 96 (8) ◽  
pp. 729-734
Author(s):  
E. G. Zarubina ◽  
Y. E. Shaldybina ◽  
I. O. Prokhorenko
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oxygen Consumption ◽  
Arterial Hypertension ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Acid Base ◽  
Obstructive Pulmonary Disease ◽  
Doppler Flowmetry ◽  
Systemic Arterial Hypertension ◽  
Microcirculatory Disorders

Material and methods. The clinical study involved 240patients (228 men and 12 women) aged 40 to 55, they were divided into 3 groups based on the duration of the disease. Patients of the first group suffered COPD disease up to 5 years, in the second group it was up to 10 years and in the third group it was more than 10 years. The degree of disturbance of microcirculation processes was investigated using laser Doppler flowmetry at the multifunction laser diagnostic complex “LAKK-M” (Russia, 2011). The following parameters were evaluated: the average perfusion value, saturation of mixed (capillary) blood, saturation of arterial blood, relative volume of the erythrocyte fraction in the skin of the middle fingertip, the index ofperfusion oxygen saturation in the microcirculation, the index of specific oxygen consumption in the tissue. The following parameters were also calculated: the efficiency of oxygen exchange, the fluorescence indicator of oxygen consumption; analysis of the frequency spectrum in the zone of myogenic, neurogenic and respiratory fluctuations of the blood flow. Results. As part of the study it was found that the increase in the prevalence of hypertension is increased in patients with COPD, depending on the duration of the disease: 2.5 times in patients of the 2nd group and 3.7 times in patients of the 3rd group compared with the patients of the 1st group. Based on the analysis of laser Doppler flowmetry data, the microcirculation index significantly changes in patients with COPD and AH in comparison with patients with isolated COPD by 5.7% (p <0.05) in the 1st group, by 11.8% (p <0.01) and 23.5% (p<0.001) in 2 and 3rd groups, respectively. Conclusion. The role of microcirculatory disorders was established in patients with comorbid pathology in the development of disorders in the gas composition parameters and acid-base balance of blood in patients with chronic obstructive pulmonary disease and systemic arterial hypertension, as well as the relationship between the duration of the anamnesis of comorbid pathology and the severity of the revealed disorders.

scholarly journals Expression Analysis of Muscle-Specific miRNAs in Plasma-Derived Extracellular Vesicles from Patients with Chronic Obstructive Pulmonary Disease

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 502
Author(s):  
Sara Carpi ◽  
Beatrice Polini ◽  
Dario Nieri ◽  
Nevio Dubbini ◽  
Alessandro Celi ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Receiver Operating Characteristic ◽  
Pulmonary Disease ◽  
Extracellular Vesicles ◽  
Operating Characteristic ◽  
Expression Profiles ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Group B

MicroRNAs (miRNAs) are a class of short non-coding RNAs involved in the regulation of gene expression and the control of several cellular processes at physiological and pathological levels. Furthermore, extracellular vesicles (EV), which are small membrane-bound vesicles secreted by cells in the extracellular environment, contain functional miRNAs. The remarkable deregulation of many miRNAs has been demonstrated in respiratory diseases. Among them, miR-206, miR-133a-5p, and miR-133a-3p are striated muscle-specific miRNAs (myo-miRNA), related to skeletal muscle dysfunction, one of the commonest systemic manifestations in patients with chronic obstructive pulmonary disease (COPD). Nevertheless, their circulating expression in COPD patients is not demonstrated. For these reasons, we performed a pilot study to analyze the expression profiles of myo-miRNAs in plasma-derived EV from patients with COPD. We analyzed the expression profiles of selected myo-miRNAs in plasma-derived EV from COPD. Receiver operating characteristic analyses were carried out to evaluate whether selected plasma miRNAs were able to discriminate between different groups of COPD patients. We found EV-embedded myo-miRNAs in the bloodstream of COPD patients. Specifically, miR-206, miR-133a-5p and miR-133a-3p were significantly upregulated in group B patients. Receiver operating characteristic analyses of the combination of these selected miRNAs showed their high capacity to discriminate group B from other COPD patients. Our data provide evidence that myo-miRNA are present in EV in the plasma of COPD patients and their expression (miR-206, miR-133a-5p, and miR-133a-3p) can discriminate group B from group C patients. The future analysis of a larger number of patients should allow us to obtain more refined correlations.

scholarly journals Acid–base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine ward

2016 ◽  
Vol 11 ◽  
Author(s):  
Alfonso Schiavo ◽  
Maurizio Renis ◽  
Mario Polverino ◽  
Arcangelo Iannuzzi ◽  
Francesca Polverino
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Respiratory Acidosis ◽  
Chronic Obstructive ◽  
Invasive Ventilation ◽  
Internal Medicine Ward ◽  
Acid Base ◽  
Obstructive Pulmonary Disease ◽  
Non Invasive ◽  
Non Invasive Ventilation

Background: Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrolite balance are closely related. Aim of the present study was to evaluate acid–base and hydroelectrolite alterations in these subjects and the effect of non-invasive ventilation and pharmacological treatment. Methods: We retrospectively analysed 110 patients consecutively admitted to the Internal Medicine ward of Cava de’ Tirreni Hospital for acute exacerbation of hypercapnic chronic obstructive pulmonary disease. On admission all patients received oxygen with a Venturi mask to maintain arterial oxygen saturation at least >90 %, and received appropriate pharmacological treatment. Non-Invasive Ventilation (NIV) was started when, despite optimal therapy, patients had severe dyspnea, increased work of breathing and respiratory acidosis. Based on Arterial Blood Gas (ABG) data, we divided the 110 patients in 3 groups: A = 51 patients with compensated respiratory acidosis; B = 36 patients with respiratory acidosis + metabolic alkalosis; and C = 23 patients with respiratory acidosis + metabolic acidosis. 55 patients received only conventional therapy and 55 had conventional therapy plus NIV. Results: The use of NIV support was lower in the patients belonging to group B than in those belonging to group A and C (25 %, vs 47 % and 96 % respectively; p < 0.01). A statistically significant association was found between pCO2 values and serum chloride concentrations both in the entire cohort and in the three separate groups. Conclusions: Our study shows that in hypercapnic respiratory acidosis due to AECOPD, differently from previous studies, the metabolic alkalosis is not a negative prognostic factor neither determines greater NIV support need, whereas the metabolic acidosis in addition to respiratory acidosis is an unfavourable element, since it determines an increased need of NIV and invasive mechanical ventilation support.

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