scholarly journals Clinical and immunological characteristics ofpatients with polyvalent food allergy in reasoning of clinical prescribing of amino acid formula

2012 ◽  
Vol 9 (1) ◽  
pp. 84-87
Author(s):  
E E Varlamov ◽  
T S Okuneva ◽  
A N Pampura
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Amino Acid ◽  
Fruits And Vegetables ◽  
Specific Ige ◽  
Food Intolerance ◽  
Cow Milk ◽  
Amino Acid Formula

Methods: 117 infants with atopic dermatitis and food allergy were enrolled. The analysis of clinical and immunological characteristics of the infants with multiple food intolerance was performed. Results: asthma, high levels of specific IgE to cow milk, egg, beef, pork, sensitization to allergens of cereals, fruits and vegetables were characterized for infants with multiple food intolerance. Conclusion: infants with multiple food intolerance possess defined clinical and immunological characteristics which can form the basis for prescribing of amino acid formula.

scholarly journals FEATURES OF DIET THERAPY IN INFANTS WITH POLYVALENTFOOD ALLERGY

2010 ◽  
Vol 7 (6) ◽  
pp. 60-63
Author(s):  
A N Pampura ◽  
E E Varlamov
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Amino Acid ◽  
Challenge Test ◽  
Specific Ige ◽  
Elimination Diet ◽  
Food Protein ◽  
Oral Challenge Test ◽  
Protein Intolerance ◽  
Amino Acid Formula

Background. Establish indications for prescription of amino acid formula to infants with atopic dermatitis. Methods. 55 infants with atopic dermatitis and food allergy were enrolled. Allergic examination included skin prick tests and evaluation of specific IgE level. Oral challenge test was performed if necessary. Results. Low efficacy of elimination diet was observed in 16 infants with multiple food protein intolerance. In the issue cluster analysis defined two subgroups. High IgE levels, specific IgE to egg and fish were considered as criterions of the first subgroup. Patients with multiple food protein intolerance and low efficacy to elimination diet received amino acid formula, SCORAD index decreased more than 50% after the first week of treatment. Conclusion. Multiple food protein intolerance is particular form of food allergy. Prescription of amino acid formula is reasonable in this category of patients.

scholarly journals DIET THERAPY IN CHILDREN WITH FOOD ALLERGY

2013 ◽  
Vol 10 (5) ◽  
pp. 70-75
Author(s):  
E E Varlamov ◽  
A N Pampura
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Amino Acid ◽  
Diet Therapy ◽  
Average Value ◽  
Multiple Food Allergy ◽  
Amino Acid Formula

Introduction. Experience of amino acid formulas application in eldest children is limited. Background. To estimate efficiency of amino acid formula at children at the age from 1 till 10 years with atopic dermatitis (AD). Methods. 9 AD children with multiple food allergy were included in the study. All patients took amino acid formula «Neocate Advance». The efficiency of diet therapy was estimated with index SCORAD. Results. The average value of index SCORAD decreased AFTER 1 week therapy, Me — 48,5 [44,5; 52,5] to Me — 18,8 [18; 37,5] a point (p=0,008), after 2 weeks — Me — 12,6 [7,8; 13,5] a point (p=0,008). Conclusion. Medical amino acid formula «Neocate Advance» is an effective diet therapy of AD children with multiple food allergy.

scholarly journals Prevention of Transcutaneous Sensitization to Cow Milk Proteins in Infants with Atopic Dermatitis: Cohort Study

2020 ◽  
Vol 19 (6) ◽  
pp. 538-544
Author(s):  
Nikolay N. Murashkin ◽  
Svetlana G. Makarova ◽  
Stepan G. Grigorev ◽  
Dmitri V. Fedorov ◽  
Roman A. Ivanov ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Maintenance Therapy ◽  
Milk Proteins ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Dispersion Analysis ◽  
Cow Milk ◽  
Group 2 ◽  
Group 1

Background. Malformations in epidermal barrier in children with atopic dermatitis (AD) can cause transcutaneous sensitization with further development of allergic diseases that can worsen the AD course and significantly reduces patients’ quality of life.Objective. The aim of the study was to determine the effect of topical treatment and maintenance therapy with pimecrolimus 1% cream (PIM) and topical glucocorticosteroids (tGCS) in infants with AD on reducing the risk of developing transcutaneous sensitization (due to the levels of specific IgE to the cow milk protein over time) and on reducing the disease severity (by the EASI scale).Methods. The study included children aged from 1 to 4 months with early manifestations of moderate and severe AD. The severity of AD was estimated via the EASI scale at start of observation, then at 6, 9 and 12 months of life. The class and level of specific IgE to cow milk proteins (CMP) were determined by the ImmunoCAP method at the point of enrolment and at the ages of 6 and 12 months. Statistical analysis of studied indicators dynamics and their comparison in research groups was carried out using multifactorial dispersion analysis.Results. The study included 36 patients. All patients have received standard tGCS therapy in combination with emollients (wet wrap) for 10 days. The maintenance therapy was prescribed in postacute period. It included topical calcineurin inhibitor PIM 2 times/day for 3 months, then double application (morning/evening) 3 times/week up to the age of 1 year old (group 1). Other group had maintenance therapy — tGCS2 times/week for 3 months, and then at AD aggravation (group 2). Group 1 has shown lower level of sensitization to CMP at the age of 6 and 12 months and more significant decrease in AD severity according to EASI scale compared to group 2.Conclusion. The treatment with PIM is effective in therapy of AD and prevention of transcutaneous sensitization in infants.

scholarly journals Camel Milk Is a Safer Choice than Goat Milk for Feeding Children with Cow Milk Allergy

ISRN Allergy ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad Ehlayel ◽  
Abdulbari Bener ◽  
Khalid Abu Hazeima ◽  
Fatima Al-Mesaifri
Keyword(s):  
Atopic Dermatitis ◽  
Prospective Study ◽  
Goat Milk ◽  
Specific Ige ◽  
Cross Reactivity ◽  
Medical Examination ◽  
Camel Milk ◽  
Cow Milk ◽  
Milk Allergy ◽  
Cow Milk Allergy

Background. Various sources of mammalian milk have been tried in CMA. Objectives. To determine whether camel milk is safer than goat milk in CMA. Methods. Prospective study conducted at Hamad Medical Corporation between April 2007 and April 2010, on children with CMA. Each child had medical examination, CBC, total IgE, cow milk-specific IgE and SPT. CMA children were tested against fresh camel and goat milks. Results. Of 38 children (median age 21.5 months), 21 (55.3%) presented with urticaria, 17 (39.5%) atopic dermatitis, 10 (26.3%) anaphylaxis. WBC was 10,039±4,735 cells/μL, eosinophil 1,143±2,213 cells/μL, IgE 694±921 IU/mL, cow's milk-specific-IgE 23.5±35.6 KU/L. Only 7 children (18.4%) tested positive to camel milk and 24 (63.2%) to goat milk. 6 (15.8%) were positive to camel, goat, and cow milks. Patients with negative SPT tolerated well camel and goat milks. Conclusions. In CMA, SPT indicates low cross-reactivity between camel milk and cow milk, and camel milk is a safer alternative than goat milk.

Skin Manifestations of Food Allergy

PEDIATRICS ◽  
2003 ◽  
Vol 111 (Supplement_3) ◽  
pp. 1617-1624 ◽  
Author(s):  
Wesley Burks
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Specific Ige ◽  
Rational Approach ◽  
Severe Atopic Dermatitis ◽  
Acute Urticaria ◽  
Skin Response ◽  
Allergic Skin ◽  
Food Challenges ◽  
Food Specific Ige

The pediatrician is faced with evaluating a panoply of skin rashes, a subset of which may be induced by food allergy. Acute urticaria is a common manifestation of an allergic skin response to food, but food is rarely a cause of chronic urticaria. Approximately one third of infants/children with moderate to severe atopic dermatitis have food allergy. Although diagnosis of acute urticaria provoked by a food may be evident from a straightforward history and confirmed by diagnostic tests to detect food-specific IgE antibody, determination of the role of food allergy in patients with atopic dermatitis is more difficult and may require additional diagnostic maneuvers, including elimination diets and oral food challenges. The immunopathologic basis of food-allergic disorders that affect the skin and a rational approach to diagnosis and treatment are discussed. Additional disorders that are caused by or mimic ones caused by food allergy are reviewed.

scholarly journals Food allergy and atopic dermatitis

2020 ◽  
Vol 2 (1) ◽  
pp. 35-38
Author(s):  
Tina Banzon ◽  
Donald Y.M. Leung ◽  
Lynda C. Schneider
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Immunoglobulin E ◽  
Growth Failure ◽  
Skin Barrier ◽  
Clinical History ◽  
Skin Inflammation ◽  
Specific Ige ◽  
Nutritional Deficiencies ◽  
Detailed Clinical History

Atopic dermatitis (AD), characterized by intense pruritus, eczematous lesions, and a relapsing disease course, is a chronic inflammatory skin disease that affects both children and adults. AD often begins in infancy and is associated with atopic diseases in the personal or family history.1 Environmental factors may trigger AD by affecting the skin barrier and by triggering inflammation. The elicitation of T-helper type 2 cytokines further impairs the epidermal barrier and leads to the penetration of irritants and allergens into the epidermis and thereby perpetuating inflammation. The presence of AD and its severity has been shown to positively correlate with risk of developing food allergy (FA). Children with AD are estimated to be six times more likely to develop FA compared with their healthy peers. It has been reported that nearly 40% of children with moderate-to-severe AD have immunoglobulin E (IgE) mediated FA compared with only 6% in the general population. Although analysis of experimental data has linked skin inflammation in AD to FA, with food challenges reproducing symptoms and avoidance diets improving AD, elimination diets are not known to cure AD and may have unfavorable consequences, such as loss of tolerance, which leads to immediate-type allergy, including anaphylaxis, nutritional deficiencies, growth failure, and reduction of quality of life for the patient and family. Exacerbation of AD can be inaccurately attributed to foods. Individuals with AD are often sensitized to foods with positive testing results, however, able to tolerate the food. In light of widespread ordering and commercial availability of serum specific IgE for FA, testing for FA is recommended only if, from a detailed clinical history, immediate-type allergic symptoms occur with ingestion of food, or in infants with AD who do not improve with optimal skin care.

scholarly journals FEATURES OF THE CYTOKINE PROFILE IN INFANTS WITH MULTIPLE FOOD PROTEIN INTOLERANCE

2012 ◽  
Vol 9 (5) ◽  
pp. 76-80
Author(s):  
E E Varlamov ◽  
T V Vinogradova ◽  
A A Chuslyaeva ◽  
A N Pampura
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Amino Acid ◽  
Inflammatory Process ◽  
Allergic Diseases ◽  
Cytokine Profile ◽  
Food Protein ◽  
Additional Indication ◽  
Protein Intolerance

Introduction. Types of the course of allergic diseases may be related to cytokine profile. Determination of the spectrum of cytokines to evaluate the mechanisms of allergic inflammatory process that improves the efficiency of management of patients with allergic diseases was performed. Background. To establish the features of cytokine profile in children with multiple food protein intolerance. Methods. 39 children with atopic dermatitis and food allergy were included in the openlabel study, 18 of whom had multiple food protein intolerance. All patients were examined with enzyme immunoassay (ELISA) to determine the concentration of IL-4, IL-5, IL-13, IL-17, IL-22, eotaxin, eotaxin2, TGF-β. Results. In children with multiple food protein intolerance the concentration of TGF-β was increased in comparison with the group of children without multiple food intolerances Me 14,04 [11,3; 18,0] against 10,3 [4,8; 12, 8] pg/ml, respectively, p = 0,038. The level of other cytokines had no difference. Conclusion. Increased concentration of TGF-β in patients with multiple food protein intolerance may be an additional indication for the amino acid formulas.

Clinical effectiveness of amino acid formula in infants with severe atopic dermatitis and cow's-milk protein allergy

2016 ◽  
Vol 91 (6) ◽  
pp. 521-527
Author(s):  
Serhiy Nyankovskyy ◽  
Olena Nyankovska ◽  
Dmytro Dobryanskyy ◽  
Oleg Shadrin ◽  
Viktoria Klimenko ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Amino Acid ◽  
Milk Protein ◽  
Clinical Effectiveness ◽  
Cow’S Milk ◽  
Severe Atopic Dermatitis ◽  
Cow's Milk ◽  
Cow’S Milk Protein ◽  
Amino Acid Formula

scholarly journals CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS

2019 ◽  
Vol 21 (5) ◽  
pp. 937-944
Author(s):  
N. A. Alkhutova ◽  
N. A. Kovyazina ◽  
O. L. Zhizhina
Keyword(s):  
Food Allergy ◽  
Clinical Signs ◽  
Specific Ige ◽  
Infants And Children ◽  
Cow Milk ◽  
School Age ◽  
Milk Allergy ◽  
Ige Antibodies ◽  
Specific Ige Antibodies ◽  
Antibody Levels

Food allergy against cow milk and its components is highly prevalent among infants and children of pre-school and young school age being a sufficient factor influencing health condition of children during the maturation period. Clinical signs of the milk allergy are non-specific, and they may be pronounced or expressed in mild form, thus enabling hypodiagnistics of this disorder. Moreover, a variety of milk antigens determines different clinical course of this allergic condition and brings additional difficulties to its diagnostics and treatment. Meanwhile, a sensibilization for the cow milk proteins may sometimes trigger a generalized atopy and bronchial asthma, being a factor delayed growth and other health disorders. At the present time, there are no distinct risk criteria for milk allergy. Therefore, its successful prophylaxis and treatment largely depends on the competence of clinical allergologist and informativity of the diagnostic techniques used. So far, however, we have no generally approved laboratory algorithms for diagnostics and monitoring of treatment efficiency in the cow milk allergy and its compomemts.We have performed a laboratory study of 187 children at the age of 3 months to 10 years. An immunochemoluminescent assay of specific IgE antibody levels to the cow milk using IMMULITE 2000/XPi analyzer has revealed its good informative value at different approaches to prediction and evaluation of food allergy treatment, both oriented for a critical cutoff value of 3 МU/L, and by monitoring a decrease in antibody levels. The authors consider rational an extended indefinity principle during the patient-oriented interpretation of IgE assay results if clinical decision is based on critical value of the index. In cases of clinical monitoring, the limit of interim reproducibility should be taken into account. The prevalence of specific cow milk antibodies among the boys was higher than among girls, however, with lesser frequency of moderate/high reactivity among the males. Moreover. the cases were detected with higher levels of anti-beta-lactalbumin IgG than those against whole milk. This finding should be considered during the screening studies.On the basis of literature analysis and own results, the authors propose an extensive study of specific IgE antibodies against cow milk and its components in blood serum of infants and children form the pre-school and junior school age groups. 

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