scholarly journals An uncommon brain abscess caused by Streptococcus intermedius due to periodontal inflammation

2017 ◽  
Vol 18 (4) ◽  
pp. 254-257
Author(s):  
Vladimír Mihál ◽  
Marta Neklanová ◽  
Eva Klásková ◽  
David Krahulík ◽  
Kamila Michálková
Keyword(s):  
Brain Abscess ◽  
Streptococcus Intermedius ◽  
Periodontal Inflammation

scholarly journals Genome Mining and Comparative Analysis of Streptococcus intermedius Causing Brain Abscess in a Child

Pathogens ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 22 ◽  
Author(s):  
Elio Issa ◽  
Tamara Salloum ◽  
Balig Panossian ◽  
David Ayoub ◽  
Edmond Abboud ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Metal Ions ◽  
Genome Evolution ◽  
Brain Abscess ◽  
Survival Rates ◽  
Genome Mining ◽  
Genomic Islands ◽  
Polymorphism Analysis ◽  
Streptococcus Intermedius ◽  
Pan Genome

Streptococcus intermedius (SI) is associated with prolonged hospitalization and low survival rates. The genetic mechanisms involved in brain abscess development and genome evolution in comparison to other members of the Streptococcus anginosus group are understudied. We performed a whole-genome comparative analysis of an SI isolate, LAU_SINT, associated with brain abscess following sinusitis with all SI genomes in addition to S. constellatus and S. anginosus. Selective pressure on virulence factors, phages, pan-genome evolution and single-nucleotide polymorphism analysis were assessed. The structural details of the type seven secretion system (T7SS) was elucidated and compared with different organisms. ily and nanA were both abundant and conserved. Nisin resistance determinants were found in 47% of the isolates. Pan-genome and SNPs-based analysis didn’t reveal significant geo-patterns. Our results showed that two SC isolates were misidentified as SI. We propose the presence of four T7SS modules (I–IV) located on various genomic islands. We detected a variety of factors linked to metal ions binding on the GIs carrying T7SS. This is the first detailed report characterizing the T7SS and its link to nisin resistance and metal ions binding in SI. These and yet uncharacterized T7SS transmembrane proteins merit further studies and could represent potential therapeutic targets.

Brain Abscess Due To Aggregatibacter Aphrophilus and Streptococcus Intermedius: A Case Report

2017 ◽  
Author(s):  
Sevliya Öcal Demir ◽  
Eda Kepenekli Kadayifci ◽  
Gülşen Akkoç ◽  
Nurhayat Yakut ◽  
Adnan Dağçınar ◽  
...  
Keyword(s):  
Case Report ◽  
Brain Abscess ◽  
Streptococcus Intermedius ◽  
Aggregatibacter Aphrophilus

Streptococcus intermedius -brain abscess in chronic granulomatous disease

1999 ◽  
Vol 158 (10) ◽  
pp. 872-873 ◽  
Author(s):  
T. Nagatomo ◽  
S. Ohga ◽  
M. Saito ◽  
H. Takada ◽  
Y. Sasaki ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Brain Abscess ◽  
Granulomatous Disease ◽  
Streptococcus Intermedius

Medullary brain abscess secondary to dental procedure caused by Streptococcus intermedius

2021 ◽  
Vol 14 (6) ◽  
pp. e240769
Author(s):  
Amit Verma ◽  
Saad Qutab ◽  
Mahum Baig
Keyword(s):  
Early Diagnosis ◽  
Head And Neck ◽  
Brain Abscess ◽  
Medulla Oblongata ◽  
Tooth Extraction ◽  
Simple Procedure ◽  
Dental Procedure ◽  
Streptococcus Intermedius ◽  
Clinical Index ◽  
Head And Neck Infections

Brainstem abscess is an uncommon occurrence in itself and an abscess in the medulla oblongata is even rarer. Although these abscesses have established association with head and neck infections, we report the first known case of medullary abscess that was found to be strongly associated with dental procedure. Important point to note is that a simple procedure like tooth extraction can predispose spread of infective seeding to distant sites. High clinical index of suspicion and early diagnosis are essential, as if left untreated, the brainstem abscess is almost always fatal otherwise.

scholarly journals Brain abscess caused by Streptococcus intermedius: a case report

2019 ◽  
Vol 77 (2) ◽  
pp. 184-186 ◽  
Author(s):  
Mouhcine Miloudi ◽  
Lamiae Arsalane ◽  
Raja Nakhli ◽  
Ghita El Ghouat ◽  
Youssef El Kamouni ◽  
...  
Keyword(s):  
Case Report ◽  
Brain Abscess ◽  
Streptococcus Intermedius

scholarly journals Characterization of the Pathogenicity of Streptococcus intermedius TYG1620 Isolated from a Human Brain Abscess Based on the Complete Genome Sequence with Transcriptome Analysis and Transposon Mutagenesis in a Murine Subcutaneous Abscess Model

2016 ◽  
Vol 85 (2) ◽  
Author(s):  
Noriko Hasegawa ◽  
Tsuyoshi Sekizuka ◽  
Yutaka Sugi ◽  
Nobuhiro Kawakami ◽  
Yumiko Ogasawara ◽  
...  
Keyword(s):  
Brain Abscess ◽  
Genome Sequence ◽  
Transcriptome Analysis ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Antimicrobial Agents ◽  
Gc Content ◽  
Streptococcus Intermedius ◽  
Content Type

ABSTRACT Streptococcus intermedius is known to cause periodontitis and pyogenic infections in the brain and liver. Here we report the complete genome sequence of strain TYG1620 (genome size, 2,006,877 bp; GC content, 37.6%; 2,020 predicted open reading frames [ORFs]) isolated from a brain abscess in an infant. Comparative analysis of S. intermedius genome sequences suggested that TYG1620 carries a notable type VII secretion system (T7SS), two long repeat regions, and 19 ORFs for cell wall-anchored proteins (CWAPs). To elucidate the genes responsible for the pathogenicity of TYG1620, transcriptome analysis was performed in a murine subcutaneous abscess model. The results suggest that the levels of expression of small hypothetical proteins similar to phenol-soluble modulin β1 (PSMβ1), a staphylococcal virulence factor, significantly increased in the abscess model. In addition, an experiment in a murine subcutaneous abscess model with random transposon (Tn) mutant attenuation suggested that Tn mutants with mutations in 212 ORFs in the Tn mutant library were attenuated in the murine abscess model (629 ORFs were disrupted in total); the 212 ORFs are putatively essential for abscess formation. Transcriptome analysis identified 37 ORFs, including paralogs of the T7SS and a putative glucan-binding CWAP in long repeat regions, to be upregulated and attenuated in vivo. This study provides a comprehensive characterization of S. intermedius pathogenicity based on the complete genome sequence and a murine subcutaneous abscess model with transcriptome and Tn mutagenesis, leading to the identification of pivotal targets for vaccines or antimicrobial agents for the control of S. intermedius infections.

scholarly journals Braın abscess due to Streptococcus intermedius secondary to mastoiditis in a child

SpringerPlus ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Nurhayat Yakut ◽  
Eda Kepenekli Kadayifci ◽  
Ayse Karaaslan ◽  
Serkan Atici ◽  
Gulsen Akkoc ◽  
...  
Keyword(s):  
Brain Abscess ◽  
Streptococcus Intermedius
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