Streptococcus intermedius -brain abscess in chronic granulomatous disease

1999 ◽  
Vol 158 (10) ◽  
pp. 872-873 ◽  
Author(s):  
T. Nagatomo ◽  
S. Ohga ◽  
M. Saito ◽  
H. Takada ◽  
Y. Sasaki ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Brain Abscess ◽  
Granulomatous Disease ◽  
Streptococcus Intermedius

scholarly journals A Streptococcus Intermedius Brain Abscess Causing Obstructive Hydrocephalus and Meningoventriculitis in an Adult Patient With Chronic Granulomatous Disease

1970 ◽  
Vol 10 (2) ◽  
Author(s):  
Fareed Kamar MD ◽  
Vinay Dhingra MD, FRCPC
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Granulomatous Disease ◽  
Brain Abscess ◽  
Obstructive Hydrocephalus ◽  
Genetic Defect ◽  
Central Nervous System Infection ◽  
Recurrent Infection ◽  
Granulomatous Disease ◽  
Streptococcus Intermedius

An inherited abnormality of phagocytosis, chronic granulomatous disease (CGD), represents an immunodeficiency characterized by recurrent infection and granuloma formation due to a genetic defect in NADPH oxidase. The 36-year-old male patient with CGD described in this case featured a brain abscess due to Streptococcus intermedius infection, complicated by meningoventriculitis and obstructive hydrocephalus. His condition was managed with broad-spectrum antibiotics, interferon gamma-1b, and bilateral external ventricular drains. This report addresses a particular paucity in the literature involving Streptococcus intermedius central nervous system infection in the adult CGD population.

scholarly journals Clinical and Demographic Pattern of Chronic Granulomatous Disease (CGD) from a Multicenter Perspective: Malaysia’s Experience Over 26 Years

2021 ◽  
Author(s):  
Lokman Mohd Noh ◽  
Amir Hamzah Abdul Latiff ◽  
Intan Hakimah Ismail ◽  
Rahim Md N ◽  
Asrul Abdul Wahab ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Brain Abscess ◽  
Positive Family History ◽  
Clinical Manifestations ◽  
Ethnic Composition ◽  
Chromobacterium Violaceum ◽  
Granulomatous Disease ◽  
Age Of Diagnosis ◽  
Patient Series ◽  
The Brain

Abstract Background:A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia.Methods: Data from the Malaysia Primary Immunodeficiency Network (MyPIN) with cases of CGD diagnosed from 1991 until 2016 were collated and analysed.Results: Twenty patients were diagnosed as CGD. Males (N=13, 65%) outnumber females (N=7, 35%). The mean age of diagnosis was 3.7 years. There was a positive family history in 40 %. Abscess was the main presenting feature in 16 patients (80%) with one involving the brain (brain abscess). Pneumonia occurred in 10 (50%) with one (1) with complicated bronchiectasis. Catalase-positive bacteria were the most commonly isolated pathogen with Chromobacterium violaceum (C violaceum) predominating, N=5 (25%) with consequent high mortality, N=4 (80%). CGD is commonest amongst the Malays (65%) followed by the Chinese (15.0%), Indians (10.0%) and natives of Borneo (10.0%) reflective of the ethnic composition of the country.Conclusion: This study has shown CGD occurs in the major ethnic groups of Malaysia. To the best of our knowledge, this is the earliest and the largest series of chronic granulomatous disease in South East Asia (SE Asia) which may be reflective of similar clinical pattern in the region. Chromobacterium violaceum infection is associated with a higher mortality in CGD patients in Malaysia. All the CGDs with (C violaceum) infection in this patient series displayed CD4+ (T helper) lymphopenia. We recorded rare clinical manifestation of CGD viz. brain abscess and bronchiectasis.

Alternaria infectoria brain abscess in a child with chronic granulomatous disease

2008 ◽  
Vol 28 (4) ◽  
pp. 377-380 ◽  
Author(s):  
E. Hipolito ◽  
E. Faria ◽  
A. F. Alves ◽  
G. S. Hoog ◽  
J. Anjos ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Brain Abscess ◽  
Granulomatous Disease ◽  
Alternaria Infectoria
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