scholarly journals Gambaran protein urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Cecillia P. Tangkin ◽  
Arthur E. Mongan ◽  
Mayer F. Wowor
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Kidney Function ◽  
Urine Specimen ◽  
Comorbid Disease ◽  
Tuberculosis Patients ◽  
Negative Results ◽  
Protein Excretion ◽  
Observational Descriptive Study ◽  
Positive Results

Abstract: Tuberculosis (TB) is an infectious disease caused by Mycobacterium Tuberculosis that can affect almost any organ, especially lungs. Anti-tuberculosis drugs, such as rifampicin and streptomicin, are nephrotoxic or destructive to kidney cells. One of the markers of kidney function deficiency is increase protein excretion in urine or proteinuria. Proteinuria is one of the markers of decreased kidney function. This study was aimed to obtain the description of protein urine on pulmonary tuberculosis patients at Prof. Dr. R. D. Kandou Hospital Manado. This was an observational descriptive study on pulmonary tuberculosis patients conducted at Prof. Dr. R. D. Kandou Hospital Manado. Samples were obtained by using random urine specimen that met the predefined criteria. Most of the tesults of protein urinalysis of 30 patients were negative for protein. Some of the patients with positive results (proteinuria) had risk factors for comorbid disease that can intervened the protein urinalysis result. Conclusion: Protein urinalysis of 30 patients showed negative results in either in-patient or out-patient of pulmonary tuberculosis patients.Keywords: pulmonary tuberculosis, urinalysis, proteinuria. Abstrak: Tuberkulosis (TB) adalah suatu penyakit infeksi yang disebabkan oleh bakteri Mycobacterium tuberculosis yang dapat menyerang berbagai organ, terutama paru-paru. Obat anti-tuberkulosis (OAT), seperti rifampisin dan streptomisin, dapat bersifat nefrotoksik atau destruktif terhadap sel-sel pada ginjal. Salah satu penanda adanya perburukan fungsi ginjal adalah ditemukan peningkatan ekskresi protein pada urin atau disebut proteniuria. Proteinuria merupakan penanda adanya perburukan fungsi ginjal. Penelitian ini bertujuan untuk mengetahui gambaran protein urin pada pasien tuberkulosis dewasa di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif observasional pada pasien tuberkulosis paru dewasa yang dilakukan di RSUP Prof. Dr. R. D. Kandou Manado. Sampel penelitian ialah sampel urin sewaktu dari semua pasien tuberkulosis paru yang memenuhi kriteria yang telah ditentukan. Berdasarkan urinalisis protein urin pada 30 pasien tuberkulosis paru, sebagian besar sampel menunjukkan hasil protein urin negatif. Beberapa pasien dengan hasil protein urin positif atau proteinuria memiliki faktor resiko penyakit penyerta yang dapat mengintervensi hasil urinalisis protein. Simpulan: dari hasil penelitian dapat disimpulkan bahwa hasil urinalisis protein pada 30 pasien tuberkulosis paru menunjukkan hasil protein urin negatif baik pada pasien rawat inap maupun rawat jalan. Kata kunci: tuberkulosis paru, urinalisis, proteinuria.

scholarly journals Gambaran leukosit urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Pingkan C. Pasuhuk ◽  
Arthur E. Mongan ◽  
Mayer Wowor
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Dipstick Test ◽  
Chemical Test ◽  
Tuberculosis Patients ◽  
Negative Results ◽  
Normal Urine ◽  
Observational Descriptive Study ◽  
Positive Results ◽  
Urine Specimens

Abstract: Tuberculosis (TB) is an infectious diseases caused by Mycobacterium Tuberculosis. Consuming the anti-tuberculosis medicine such as streptomycin and rifampicin will cause nephrotoxic effect. In kidney disfunction especially the glomeruli, the number of leukocytes in the urine increase. The most common urinalysis tests are chemical test and microscopic test, especially the leukocyte urine test. These tests can be used to detect the kidney disfunction and the urinary tract infection. In normal urine, the result of the dipstick test is negative, and the result of microscopic test is 0-5/HPF. This study was aimed to obtain the description of leukocyte urinalysis in pulmonary tuberculosis patients at Prof. Dr. R. D. Kandou Hospital Manado. This was an observational descriptive study conducted in October-November 2016 at Prof. Dr. R. D. Kandou Hospital Manado. Samples were random urine specimens that met the predefined criteria. The results showed that based on the urinalysis, of 30 patients with pulmonary tuberculosis, 27 patients had negative results and 3 patients had positive results. Conclusion: There was no relationship between urine leucocyte and pulmonary tuberculosis in adult patients.Keywords: pulmonary tuberculosis, urinalysis, urine leukocyte Abstrak: Tuberkulosis (TB) merupakan penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis. Obat anti-tuberkulosis seperti streptomisn dan rifampisin memiliki efek nefrotoksik. Kerusakan ginjal terutama glomerulus dapat menimbulkan peningkatan leukosit dalam urin. Metode urinalisis yang sering digunakan yaitu uji kimia/ carik-celup dan mikroskopik. Pemeriksaan leukosit urin dapat digunakan untuk mengetahui adanya gangguan pada ginjal dan infeksi saluran kemih. Pada urin normal hasil pemeriksaan dipstick negatif dan hasil pemeriksaan mikroskopik urin 0-5 leukosit/LPB. Penelitian ini bertujuan untuk mendapatkan gambaran leukosit urin pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif observasional dan dilakukan pada bulan Oktober-November 2016 di RSUP Prof. Dr. R. D. Kandou Manado. Sampel penelitian ialah sampel urin sewaktu dari semua pasien tuberkulosis paru yang memenuhi kriteria yang telah ditentukan. Hasil urinalisis dari 30 pasien terdiagnosis penyakit tuberkulosis paru mendapatkan 27 pasien dengan hasil negatif dan 3 pasien dengan hasil positif. Simpulan: Tidak terdapat hubungan antara leukosit urin dengan tuberkulosis paru dewasa. Kata kunci: TB paru, urinalisis, leukosit urin

scholarly journals Gambaran pemeriksaan makroskopis urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Vivin Mustikawangi ◽  
Glady I. Rambert ◽  
Mayer Wowor
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Side Effect ◽  
Research Method ◽  
Urine Specimen ◽  
Tuberculosis Patients ◽  
Almost All ◽  
Macroscopic Examination ◽  
Urine Colour

Abstract: Tuberculosis (TB) is an infectious disease caused by Mycobacterium Tuberculosis. Anti-tuberculosis drugs have nephrotoxic and hepatotoxic side effect. Renal and liver damage caused by the side effect of anti-tuberculosis drugs will make some changes in macroscopic urinalysis. Research Objective: To understand the description of macroscopic urinalysis on pulmonary tuberculosis patients in RSUP Prof. Dr. R. D. Kandou Manado. Research Method: Observational descriptive, to obtain the data of macroscopic urinalysis on pulmonary tuberculosis patients conducted in October - November 2016 at RSUP Prof. Dr. R. D. Kandou Manado.The research samples were random urine specimen and 24-hour urine specimen that meet with the predefined criteria. Result: Based on macroscopic urinalysis results on 30 patients, almost all of the colour, odour, clarity and volume examination results were normal. Only a couple of patients have macroscopic changes. Although in colour examination, rifampicin changes urine colour to orange. Conclusion: Based on the result, it can be concluded that macroscopic urinalysis on pulmonary tuberculosis patients either in-patient or out patient showed that there are no abnormalities in almost all of them.Keywords: pulmonary tuberculosis, urinalysis, macroscopic examination Abstrak: Tuberkulosis (TB) adalah penyakit akibat infeksi bakteri Mycobacterium Tuberculosis. Obat yang diberikan pada pasien TB bersifat nefrotoksik dan hepatotoksik. Kerusakan ginjal dan hati yang disebabkan oleh efek samping obat tersebut akan menunjukkan perubahan pada pemeriksaan makroskopis urin. Tujuan Penelitian: untuk mengetahui gambaran pemeriksaan makroskopis urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado. Metode Penelitian: deskriptif observasional, untuk mendapatkan data tentang pemeriksaan makroskopis urin pada pasien tuberkulosis paru dewasa yang dilakukan sejak oktober-november 2016 di RSUP. Prof. Dr. R. D. Kandou Manado. Sampel penelitian adalah sampel urin sewaktu dan 24 jamdari semua pasien tuberkulosis paru yang memenuhi kriteria yang telah ditentukan. Hasil: Berdasarkan urinalisis pemeriksaan makroskopis pada 30 pasien, pemeriksaan warna, bau, kejernihan, dan volume sebagian besar normal. Hanya beberapa pasien yang mengalami perubahan makroskopis.Pada pemeriksaan warna, pemakaian rifampisin menyebabkan urin berwarna jingga. Simpulan: dari hasil penelitian dapat disimpulkan bahwa antara pemeriksaan makroskopis urin dengan pasien tuberkulosis paru dewasa baik yang dirawat inap maupun rawat jalan menunjukan hampir semua tidak ada kelainan. Kata kunci: tuberkulosis paru, urinalisis, pemeriksaan makroskopis

scholarly journals Gambaran bilirubin dan urobilinogen urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Faleriano Makay ◽  
Glady I. Rambert ◽  
Mayer F. Wowor
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Normal Level ◽  
Random Sampling ◽  
Descriptive Study ◽  
Tuberculosis Patient ◽  
Inclusion Criteria ◽  
Tuberculosis Patients ◽  
Observational Descriptive Study ◽  
Hepatotoxic Drug

Abstract: Tuberculosis is an infectious disease caused by the bacillus Mycobacterium tuberculosis. Antituberculosis drugs prescribed to TB patients is hepatotoxic drug. Liver damage caused by side effects of the drugs will cause an alteration in urinary bilirubin and urobilinogen level. This study was aimed to obtain the profile of urinary bilirubin and urobilinogen in adult pulmonary tuberculosis patients at Prof. Dr. R. D. Kandou Hospital Manado from October to November 2016. This was an observational descriptive study. Samples obtained by using random sampling urine from all pulmonary tuberculosis patient that met the inclusion criteria. The results showed that according to urinary bilirubin and urobilinogen examination in 30 patients, most of them were in normal level. Only 6 out of 30 patients has bilirubinuria in this urinary bilirubin examination. In urinary urobilinogen examination, all results is in normal level. Conclusion: Urinary bilirubin and urobilinogen examination in this research was normal in general, bilirubinemia was found only in some patients.Keywords: pulmonary tuberculosis, urinary bilirubin, urinary urobilinogen Abstrak: Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh basil Mycobacterium tuberculosis. Obat antituberkulosis yang diberikan pada pasien TB bersifat hepatotoksik. Kerusakan hepar yang disebabkan oleh efek samping obat tersebut akan menyebabkan perubahan pada kadar bilirubin dan urobilinogen urin. Tujuan penelitian untuk mengetahui gambaran bilirubin dan urobilinogen urin pada pasien tuberkulosis paru dewasa di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif observasional, untuk mendapatkan data tentang bilirubin dan urobilinogen urin pada pasien tuberkulosis paru dewasa di RSUP. Prof. Dr. R. D. Kandou Manado pada Oktober-November 2016. Sampel penelitian adalah sampel urin sewaktu dari semua pasien tuberkulosis paru yang memenuhi kriteria inklusi. Hasil penelitian memperlihatkan berdasarkan pemeriksaan bilirubin dan urobilinogen urin pada 30 pasien, sebagian besar kadarnya normal. Hanya 6 dari 30 pasien yang mengalami bilirubinuria pada pemeriksaan bilirubin urin. Pada pemeriksaan urobilinogen urin semua hasil dalam batas normal. Simpulan: Pemeriksaan bilirubin dan urobilinogen urin pada umumnya normal, hanya beberapa pasien yang mengalami bilirubinuria.Kata kunci: tuberkulosis paru, bilirubin urin, urobilinogen urin

Detection of Mycobacterium tuberculosis in smear negative sputum by PCR

2012 ◽  
Vol 6 (2) ◽  
pp. 2-6 ◽  
Author(s):  
Mohammad Jobayer ◽  
SM Shamsuzzaman ◽  
Kazi Zulfiquer Mamun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Accurate Method ◽  
Major Health Problem ◽  
Major Health ◽  
Tuberculosis Patients ◽  
Diagnostic Potential ◽  
Total Death ◽  
Smear Negative ◽  
Negative Sputum

Pulmonary tuberculosis is a major health problem in Bangladesh that is responsible for about 7% of total death in a year. This study was conducted to isolate and identify Mycobacterium tuberculosis from sputum and to evaluate the efficacy of PCR as a modern diagnostic tool, for diagnosis of pulmonary tuberculosis, especially in the smear negative cases. One hundred and fifty suspected pulmonary TB patients (male/ female: 97/53) were included in this study. Single morning sputum was collected from each patient and diagnostic potential of PCR was compared with staining and culture. Twenty five (16.7%) sputum were positive by ZN stained smear. Among 125 smear negative samples, 13 (10.4%) yielded growth in culture in LJ media and 21 (16.8%) samples were positive by PCR. The sensitivity and specificity of PCR in smear negative cases was 100% and 92.9% respectively. Mean detection time in PCR was 24 hours. PCR detected M. tuberculosis in 21 smear negative and 9 culture negative samples. For diagnosis of tuberculosis in smear negative cases, PCR directly from sputum was a very sensitive and accurate method. In conclusion, PCR may be done, especially in clinically suspected pulmonary tuberculosis patients who remain negative by conventional methods.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19368 Bangladesh J Med Microbiol 2012; 06(02): 2-6

Determination some Immunological Aspects in Pulmonary Tuberculosis Patients in Qadisiyah Province

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Syoof Khowman Alramahy ◽  
Akram Hadi Hamza
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Statistical Difference ◽  
Positive Culture ◽  
Control Group ◽  
Tuberculosis Patients ◽  
Significant Difference ◽  
Lowenstein Jensen ◽  
The Mean ◽  
Igg Level

This study was carried out to study of some immunological aspects among the pulmonary Tuberculosis patients infected with causative agent, Mycobacterium tuberculosis. A Total of 200 sputum samples were collected from patients attending the consultant Clinic for Chest and Respiratory disease center, Diwaniya. Control group (No=15) also included. According to acid fast stain of sputum, the patients were classified as positive (No=91,45.5%) and negative (No=109,54.5, Lowenstein Jensen medium used for the cultivation of samples, on which 70% of sputum samples where positive culture for this microorganism. The grown microorganism were identified as M. tuberculosis, based on positive A.F.B, Niacin producers ,negative for catlase at 68c. The mean IgG level was l184.053±76.684 mg/100 ml in tuberculosis group compared with 1016.533 ± 44.882 mg/100ml in control group, rendering the statistical difference significant. For IgA and IgM levels, they were at mean of 315.880±38.552 mg/100 ml and 119.527±8.464 mg/100 ml in control group compared with 396.358±38.776 mg/100 ml and 134.207±11.696 mg/100 ml in patients group respectively with significant difference

scholarly journals Treatment of Tuberculosis in South Kazakhstan: Clinical and Economical Aspects

Medicina ◽  
2013 ◽  
Vol 49 (7) ◽  
pp. 52 ◽  
Author(s):  
Talgat Maimakov ◽  
Laura Sadykova ◽  
Zhanna Kalmataeva ◽  
Kural Kurakpaev ◽  
Kastytis Šmigelskas
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Treatment Outcomes ◽  
Financial Resources ◽  
Drug Resistant ◽  
Test Results ◽  
Negative Results ◽  
Resistant Tuberculosis ◽  
Extensively Drug Resistant ◽  
Positive Treatment ◽  
Positive Results

Background and Objective. Since 1990, the tuberculosis incidence rate in Eastern Europe and post-Soviet republics has been increasing in many countries including Kazakhstan. This problem is particularly important in Kazakhstan regions with limited financial resources, among them – in South Kazakhstan province. The aim of this study was to investigate the main clinical and antibiotic-related economic aspects of tuberculosis treatment in South Kazakhstan province. Material and Methods. In total, 502 patients participated in the study. They were hospitalized to the tuberculosis dispensary of Sayram district (South Kazakhstan province) in 2007–2013. Statistical analysis included logistic regression for better treatment outcomes and analysis of antibiotic treatment costs. Results. Two-thirds of patients had infiltrative tuberculosis (67%). Positive treatment outcomes were determined in 85% of cases. The patients were mostly treated with cycloserine, protionamide, capreomycin, and ofloxacin. The majority of antibiotic costs were related to the treatment with capreomycin. In case of the positive results of the test for Mycobacterium tuberculosis, antibiotic expenses were almost 3 times greater than in case of negative test results (P<0.001). Conclusions. The majority of patients had extensively drug-resistant tuberculosis. The negative results of the test for Mycobacterium tuberculosis at discharge were not related to pretreatment factors. Antibiotic-related costs were significantly higher in case of the positive results of the test of Mycobacterium tuberculosis, but were not associated with gender, residence place, hospitalization recurrence, or main blood test results before treatment.

Sign in / Sign up

Export Citation Format

Share Document