scholarly journals Can psychobiotics administration influence behavioral responses and physiological stress in healthy rats?

2021 ◽  
Author(s):  
Mohammad Morshedi ◽  
Khadijeh Bavafa Valenlia ◽  
Maryam Saghafi-Asl ◽  
Saeid Hadi ◽  
Vahid Hadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Physiological Stress ◽  
Behavioral Responses ◽  
Control Group ◽  
Beneficial Effects ◽  
Disease States ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
And Control

Background: There is a well-documented cross-talk between the gut and brain. Evidence is accumulating to suggest beneficial effects of psychobiotics [prebiotics, probiotics or synbiotics] on psychological distress in disease states. However, their role in healthy status remains relatively unclear. Objectives: The present study was aimed to clarify if psychobiotics could influence behavioral responses and physiological stress in healthy rats. Methods: In the present experiment, 28 male Wistar rats were divided into four groups (healthy rats treated by Lactobacillus plantarum (L.plantarum), inulin and their combination (synbiotic) and control group). Then, psychobiotics were administered to the intervention groups for 8 weeks. Behavioral tests (Morris water maze, Elevated plus maze, and Forced swimming test) were performed at the endpoint. Then, serum and brain levels of superoxide dismutase, malondialdehyde, glutathione peroxidase, total antioxidant capacity, brain-derived neurotrophic factor (BDNF), and serotonin were measured. Results: Our finding indicated that unlike inulin, the administration of L.plantarum and synbiotic could ameliorate depression and anxiety-like behavior and cognitive performance (P<0.05). Serum and brain oxidative stress markers were significantly improved by synbiotic consumption. Intake of L.plantarum led to decreased oxidative stress in the hippocampus and amygdala (P<0.05). Moreover, a significant increase in hippocampal serotonin and BDNF concentration was observed after synbiotic and L.plantarum intake (P<0.05). In addition, there was a strong correlation of serum and brain markers with behavioral performance (P< 0.05). Conclusion: Our study suggests that psychobiotics therapy may have favorable effects on the amelioration of psychological disorders.

scholarly journals Can Psychobiotics Administration Influence Behavioral Responses and Physiological Stress in Healthy Rats?

2021 ◽  
Author(s):  
Mohamad Morsheedi ◽  
Khadijeh Bavafa Valenlia ◽  
Maryam Saghafi-Asl ◽  
Saeid Hadi ◽  
Vahid Hadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Physiological Stress ◽  
Behavioral Responses ◽  
Depression And Anxiety ◽  
Beneficial Effects ◽  
Disease States ◽  
Stress Markers ◽  
Bidirectional Communication ◽  
Male Wistar Rats ◽  
Brain Oxidative Stress

Abstract Background: Bidirectional communication between gut and brain function is well demonstrated. Evidence is accumulating to suggest that psychobiotics [prebiotics, probiotics or synbiotics)] have beneficial effects of on psychological distress in disease states. However, their role in healthy status remains relatively unclear.Aims: Therefore, we aimed to clarify if psychobiotics (L.plantarum, inulin or their combination) can influence behavioral responses and physiological stress in healthy rats.Methods: Twenty-eight male Wistar rats were divided into four groups. Then, psychobiotics were administered to intervention groups for 8 weeks. Behavioral tests were performed at the end of the intervention.Results: Our finding indicated that unlike inulin, the administration of L.plantarum and synbiotic could ameliorate depression and anxiety-like behavior and cognitive performance. Serum and brain oxidative stress markers were significantly improved by synbiotic consumption. Also, intake of L.plantarum resulted in the decreased oxidative stress in the hippocampus and amygdala. In addition, a significant increase in hippocampal serotonin and BDNF concentration was observed after symbiotic and L.plantarum intake. Furthermore, there is a strong correlation between serum and brain markers with behavioral performances. Conclusion: Our study suggests that administration of psychobiotics therapy may be associated with prevent or ameliorate psychological disorders.

Probable antioxidant therapy of Saffron Crocin in patients with multiple sclerosis: A randomized controlled trial

Biomedicine ◽  
2021 ◽  
Vol 40 (4) ◽  
pp. 516-521
Author(s):  
Sara Ami Ahmadi ◽  
Azin Kazemi ◽  
Mohammadmahdi Sabahi ◽  
Shahab Razipour ◽  
Arash Salehipour ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Controlled Trial ◽  
Stress Factors ◽  
Control Group ◽  
Oxidative Damages ◽  
Significant Difference ◽  
Daily Dose ◽  
Total Antioxidant ◽  
And Control

Introduction and Aim: Multiple Multiple sclerosis (MS) is a complex neurological condition  might emerge as a result ofcomplex combination of genetic risk factors with environmental triggers, including oxidative stress. in this study we aimed to evaluate the effects of oral Crocin on oxidative stress in patients with MS.  Materials and Methods: Adjunct to standard treatment, the Crocin group (20 patients) received 30-mg/day (15 mg twice daily) dose of Crocin and placebo group (20 patients) received for 4 weeks. Saliva and urine samples were collected to determine the levels of total antioxidant capacity (TAC), catalase activity (CAT), total thiol groups (TTG), lipid peroxidation (LPO), were measured at baseline and the end of the study.   Results: At baseline, there were no significant differences of LPO, TAC, CAT, and TTG of urine between the control and case groups. However, a significant difference was found after 4 weeks of Crocin-therapy in TTG,TAC and LPO (p<0.05) except in CAT activity (P>0.05). We found no deffrence in urinary TTG level and CAT activity in control group at the end of intervention (P>0.05), while TAC and LPO level were significantly different at the end of the study as compared with the beginning (P<0.05). Althugh, we found no significant difference in saliva LPO, TTG and TAC levels and the activity of CAT in case and control groups at first (p>0.05), Crocin administration have resulted in a significant increase in saliva TTG and TAC levels as well as CAT activity and markedly decrease in LPO level (p<0.05). Conclusion: According to the results of this study, Crocin can significantly reduce the several oxidative stress factors in MS patients and may contributes to attenuates the oxidative damages.

scholarly journals Oxidative Stress in Children with Chronic Spontaneous Urticaria

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Fatih Dilek ◽  
Deniz Ozceker ◽  
Emin Ozkaya ◽  
Nermin Guler ◽  
Zeynep Tamay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Total Antioxidant Status ◽  
Chronic Spontaneous Urticaria ◽  
Control Group ◽  
Stress Markers ◽  
Extensive Evaluation ◽  
Median Plasma ◽  
Total Antioxidant ◽  
Healthy Control ◽  
The Difference

The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements. The median value of plasma TOS was found to be 10.49 μmol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 μmol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (p=0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp.,p= 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity.

scholarly journals 4-Hydroxy-2-nonenal Statues in Hypertension Patients

2017 ◽  
Author(s):  
Alaa H. Jawad ◽  
Ammal E. Ibrahim ◽  
Ali Hammed ◽  
Zyad Al-Qaisi ◽  
Amamer Redwan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Control Group ◽  
Hypertensive Subject ◽  
Oxidative Stress Markers ◽  
Ideal Weight ◽  
Stress Markers ◽  
Main Factors ◽  
And Control ◽  
The Relationship

The oxidative stress is one of the main cause for cardiovascular diseases&nbsp; (like Hypertension) also one of the results of these diseases.&nbsp; This study involved 56 subjects matched ages&nbsp; and sex divided into two groups; 28 hypertensive subject and 28 healthy subject as control group. The following analysis was done: 4-Hydroxy-2-nonenal(4HNE) and albumin. The results show that there is a significant increase in (4HNE) between patients group and control group. The increase in 4HNE which is a product of lipid peroxidation&nbsp; is attributed to destruction in body cell caused by due to the increase in stress events. It has been concluded that is important nappy on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. The aim of this study was to investigate the relationship between of some oxidative stress markers and cardiovascular diseases.

scholarly journals Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress

2020 ◽  
Vol 8 (2) ◽  
pp. 53-57
Author(s):  
Somayyeh Mohammadi Pasand ◽  
Akram Ranjbar ◽  
Nejat Kheiripour ◽  
Hassan Ghasemi ◽  
Hassan Rafieemehr
Keyword(s):  
Oxidative Stress ◽  
Saline Group ◽  
Control Group ◽  
Aluminum Phosphide ◽  
Daily Group ◽  
Oxidative Stress Level ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Antioxidative Effects ◽  
Almost All

Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AIP. Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving curcumin (100 mg/kg daily); group Nano-cur receiving nanocurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and nanocurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured. Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P<0.05). Curcumin and nanocurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P<0.05). Moreover, in the nanocurcumin-treated groups, compared to a poisoned group, TAC and TTG increased significantly (P<0.01). There were no significant changes in CAT activity improvement. Conclusion: Nanocurcumin and curcumin improved the AIP-induced oxidative damage.

scholarly journals Assessment of dynamic thiol/disulfide homeostasis in patients with asthma

2018 ◽  
Vol 42 (3) ◽  
pp. 99-104
Author(s):  
Rukiye Nar ◽  
Aliye Gamze Çalış
Keyword(s):  
Oxidative Stress ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Reactive Protein ◽  
Total Thiol ◽  
Stress Markers ◽  
Group A ◽  
And Gender ◽  
And Control

Abstract Background: Asthma is a chronic inflammatory lung disease and oxidative stress is an important component in airway inflammation. This study aims to investigate dynamic thiol/disulfide homeostasis in patients with asthma. Methods: A total of 103 subjects, including 56 patients with asthma and 47 healthy controls, of similar age and gender were included in the study. The native thiol, total thiol and disulfide levels and the disulfide-native thiol, disulfide-total thiol and native thiol-total thiol ratios were analyzed and compared between the asthma and control groups using a novel automatized spectrophotometric assay. Results: The levels of native thiol (p<0.001), total thiol (p<0.001) and disulfide (p<0.001) were significantly lower and the C-reactive protein (CRP) levels (p<0.001) were significantly higher in patients with asthma when compared with those in the control group. A negative correlation was detected between CRP levels and native thiol, total thiol and disulfide levels (p<0.05). A significant positive correlation was detected between forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) levels and native thiol and total thiol levels (p<0.01). Conclusions: The thiol/disulfide homeostasis parameters may be used as novel oxidative stress markers in asthma but further studies are needed to investigate the role of thiol/disulfide homeostasis in asthma.

scholarly journals Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Qiaozhen Zhou ◽  
Li Zhu ◽  
Dafeng Zhang ◽  
Ning Li ◽  
Qiao Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Postmenopausal Osteoporosis ◽  
Meta Analysis ◽  
Total Antioxidant Status ◽  
Control Group ◽  
Antioxidant Power ◽  
Total Antioxidant ◽  
Mean Differences ◽  
Meta Analyses ◽  
And Control

Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.

scholarly journals Oxidative stress during rehabilitation from protein malnutrition associated with aerobic exercise in rats

2007 ◽  
Vol 50 (1) ◽  
pp. 45-55 ◽  
Author(s):  
Francisco José Andriotti Prada ◽  
Denise Vaz Macedo ◽  
Maria Alice Rostom de Mello
Keyword(s):  
Oxidative Stress ◽  
Physical Exercise ◽  
Aerobic Exercise ◽  
Body Weight Gain ◽  
Protein Malnutrition ◽  
Protein Diet ◽  
Control Group ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Normal Protein Diet

This study was designed to evaluate biomarkers of oxidative stress in rats with or without aerobic exercise during recovery from protein malnutrition. From the 30th to the 90th day of life, male Wistar rats were fed a low protein diet (LP + 6%) followed by a normal protein diet (NP = 17%) until the 120th day and separated in two groups: sedentary (S) and exercise trained (E = swimming 1h/day, 5 days/week, with from the 90th to the 120th day). Rats fed a normal protein diet were used as controls. Results showed that physical exercise had beneficial effects on body weight gain during nutrition rehabilitation. Erythrocytes catalase and glutathione reductase (biomarkers of the antioxidant system) were significantly reduced in all groups in comparison to the sedentary control group. The plasma concentration of TBARs (biomarkers of the oxidative damage) was also lower in the recovered rats, suggesting that the improvement in body growth after nutritional rehabilitation with physical exercise could be related to a decrease in the oxidative stress level.

scholarly journals Impact of Ileal Transposition Surgical Intervention on Antioxidant Status Measured in Liver Tissue of Obese Zucker Rats (Crl:ZUC-Leprfa)

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Bronisława Skrzep-Poloczek ◽  
Dominika Stygar ◽  
Tomasz Sawczyn ◽  
Ewa Romuk ◽  
Elżbieta Chełmecka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Tissue ◽  
Antioxidant Status ◽  
Zucker Rats ◽  
Control Group ◽  
Ileal Transposition ◽  
Control Groups ◽  
Sham Procedure ◽  
Total Antioxidant ◽  
And Control

Background. The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects. Aims. To assess the effect of ileal transposition (IT) and sham types of bariatric procedures on the antioxidative systems in the liver tissue of Zucker rats (Crl:ZUC Leprfa). Method. 21 animals were divided into the experimental groups: control group (n=7), sham group (n=7), and IT group (n=7). Sham and IT animals underwent selected surgery. The concentration of total antioxidant capacity (TAC), total antioxidant status (TOS), and activity of glutathione reductase (glutathione-disulfide reductase, GR, GSR), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and total superoxide dismutase activity (SOD) were assessed in liver tissue 3 months after surgery. Results. IT procedure significantly increased TAC when compared to sham and the control group. Animals after IT showed higher levels of TOS when compared to sham procedure. The total amount of TOS was similar in IT and control groups. GPx activity was increased in the groups submitted to the sham and IT surgery in relation to control. GR and CAT activities were significantly higher after IT in comparison to control and sham procedures. Total SOD and MnSOD were significantly higher in sham-operated animals in comparison to IT intervention and control groups. Conclusions. IT procedure had a positive impact on the diminishing of oxidative stress measured by TAC and TOS markers. The dynamic, adaptive, and protective mechanisms of enzymatic antioxidant systems were observed after the IT but not sham procedure. Nevertheless, 3 months after surgery, the midterm effect of bariatric surgery was observed, which might not fully balance the antioxidative response.

scholarly journals Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1853
Author(s):  
Lorena Fuentes-Broto ◽  
Lorena Perdices ◽  
Francisco Segura ◽  
Elvira Orduna-Hospital ◽  
Gema Insa-Sánchez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinitis Pigmentosa ◽  
Visual Function ◽  
Age Related Macular Degeneration ◽  
Antioxidant Defenses ◽  
Wild Type ◽  
Beneficial Effects ◽  
Stress Markers ◽  
Age Related ◽  
Total Antioxidant

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidative stress in the retina, aqueous humor, plasma, and liver of RP animal models and patients. Melatonin has beneficial effects against age-related macular degeneration, glaucoma, and diabetic retinopathy, in which oxidative stress plays a key role. In the present study, we used the P23HxLE rat as an animal model of RP. Melatonin treatment (10 mg/kg b.w. daily in drinking water for 6 months) improved the parameters of visual function and decreased the rate of desynchronization of the circadian rhythm, both in P23HxLE and wild-type rats. Melatonin reduced oxidative stress and increased antioxidant defenses in P23HxLE animals. In wild-type animals, melatonin did not modify any of the oxidative stress markers analyzed and reduced the levels of total antioxidant defenses. Treatment with melatonin improved visual function, circadian synchronization, and hepatic oxidative stress in P23HxLE rats, an RP model, and had beneficial effects against age-related visual damage in wild-type rats.

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