scholarly journals Association of plasma total testosterone level and metabolic syndrome in adult males

2019 ◽  
Vol 9 (3) ◽  
pp. e27-e27
Author(s):  
Alireza Hejrati ◽  
Amir Ziaee ◽  
Mohammad Pourmahmudian ◽  
Elham Bayani ◽  
Mehrnaz Ghavamipour ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Testosterone Level ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Plasma Testosterone ◽  
Adult Males ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
The Relationship

Introduction: Low testosterone level has strongly been correlated with body fat accumulation and abdominal obesity in men. Objectives: This study aimed to evaluate testosterone level in men with and without metabolic syndrome to determine the relationship between testosterone and metabolic syndrome. Patients and Methods: This case-control study was conducted on 172 cases of metabolic syndrome and 172 participants as a control group in Rasoul Akram hospital, Tehran, Iran. Demographic characteristics, fasting blood sugar (FBS), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, triglyceride (TG), and testosterone levels were recorded. SPSS version 21.0 and SAS version 9.1 were used for statistical analysis. Level of significance was considered 0.05. Results: The mean age of the two groups were 45.1±9.3 years and 41.5 ±11.2 years, respectively. There was a significant difference in serum testosterone levels between both groups and low testosterone levels were associated with metabolic syndrome (P<0.001). Serum testosterone levels showed a significant negative correlation with age in the metabolic syndrome group (r= -0.16, P=0.02). The relationship between metabolic syndrome and total plasma testosterone level using logistic regression model showed that, by increasing the total plasma testosterone level, the odds ratio for metabolic syndrome was 0.076 (95% CI: 0.027-0.216; P< 0.001). Conclusion: According to the results, low level of testosterone was related to the presence of metabolic syndrome in adult males. Future studies can investigate diagnostic value of testosterone level in this syndrome.

Relationship between serum total testosterone and prostate volume in aging men

2021 ◽  
Author(s):  
Bo-Wen Xia ◽  
Si-Cong Zhao ◽  
Zong-Ping Chen ◽  
Chao Chen ◽  
Tian-Shu Liu ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Prostate Volume ◽  
Serum Testosterone ◽  
Total Testosterone ◽  
Related Factors ◽  
Testosterone Levels ◽  
Aging Men ◽  
Low Testosterone ◽  
The Relationship ◽  
Relevant Factors

Abstract Objectives Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. Materials and methods We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Results Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs 24.06 ± 6.77 p = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all p < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (p = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. Conclusion These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.

scholarly journals Relationship between serum total testosterone and prostate volume in aging men

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bo-Wen Xia ◽  
Si-Cong Zhao ◽  
Zong-Ping Chen ◽  
Chao Chen ◽  
Tian-Shu Liu ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Prostate Volume ◽  
Serum Testosterone ◽  
Total Testosterone ◽  
Related Factors ◽  
Testosterone Levels ◽  
Aging Men ◽  
Low Testosterone ◽  
The Relationship ◽  
Relevant Factors

AbstractTotal testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.

PLASMA LEVELS OF TESTOSTERONE IN BULLS

1978 ◽  
Vol 88 (4) ◽  
pp. 787-792 ◽  
Author(s):  
Anne Sundby ◽  
P. A. Torjesen
Keyword(s):  
Testosterone Level ◽  
Plasma Levels ◽  
Leydig Cells ◽  
Sharp Decrease ◽  
Plasma Testosterone ◽  
Plasma Samples ◽  
Elevated Plasma ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Testosterone Production

ABSTRACT Administration of 6000 IU HCG to 4 bulls was followed by an elevation of plasma testosterone lasting for 9–13 days. When HCG administration was repeated, the testosterone response was shortened to 4–6 days in 3 bulls due to the formation of antibodies against HCG. The appearance of HCG antibodies coincided with a sharp decrease in the plasma testosterone level, indicating that Leydig cells have to be under continuous HCG stimulation to maintain increased testosterone production. No antibody against bovine LH was detected in the plasma samples containing antibodies against HCG. In one bull the response following the second HCG injection was similar to the plasma testosterone pattern following the first. No antibodies against HCG were found in this bull. Five bulls received 750 IU HCG twice. Following the period with elevated plasma testosterone levels, subnormal levels were observed after both injections. One injection led to decreased levels without development of antibodies against HCG while the second HCG injection led to subnormal testosterone levels concomitant with measurable antibodies against HCG.

scholarly journals The association between serum testosterone levels and metabolic syndrome among women

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Junxiao Liang ◽  
Qiaohua Peng ◽  
Xinyun Yang ◽  
Chunbo Yang
Keyword(s):  
Metabolic Syndrome ◽  
Testosterone Level ◽  
Menopausal Status ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Total Serum ◽  
Female Population ◽  
Logistic Regression Models ◽  
Health And Nutrition ◽  
The Relationship

Abstract Background This study aimed to investigate the relationship between total serum testosterone level (TT) and metabolic syndrome (MetS) among adult female population. Subgroup analysis further stratified the population by menopausal status to address the potential hormonal difference in postmenopausal women. Methods A total of 1966 participants from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 cycle was included for analysis in this study. MetS was defined based on the National Cholesterol Education Program Adult Treatment Panel III guidelines. Serum TT was collected during the physical examination of the NHANES program and divided into quartiles (Q) in this analysis. Menopausal status was determined based on NHANES Reproductive Health Questionnaire. Logistic regression models were applied for analysis. Results The odds of MetS in Q2: 12.99–19.38 ng/mL (OR = 0.641, 95%CI 0.493–0.835, P < 0.01), Q3: 19.39–28.38 ng/mL (OR = 0.476, 95%CI 0.362–0.626, P < 0.001), and Q4: ≥28.40 ng/mL (OR = 0.390, 95%CI 0.294–0.517, P < 0.001) were statistically lower compared to the reference Q1: <12.99 ng/mL. For the postmenopausal group, a significantly lower odds of MetS was observed in the Q2 (OR = 0.689, 95%CI 0.486–0.977, P < 0.05) and Q4 (OR = 0.606, 95%CI 0.399–0.922, P < 0.05), while the odds of Q3 (OR = 0.439, 95%CI 0.248–0.779, P < 0.01) and Q4 (OR = 0.464, 95%CI 0.261–0.825, P < 0.01) were significantly lower than the reference Q1 in the premenopausal group. Conclusions Elevated TT levels are associated with incremental reductions in the odds of metabolic syndrome among adult females. Although, serum testosterone level is associated with the occurrence of metabolic syndrome in both the postmenopausal and the premenopausal group, the patterns of the relationship are different.

A CASE OF MALE PSEUDOHERMAPHRODITISM ASSOCIATED WITH ELEVATED LH, NORMAL FSH AND LOW TESTOSTERONE POSSIBLY DUE TO THE SECRETION OF AN ABNORMAL LH MOLECULE

1976 ◽  
Vol 83 (1) ◽  
pp. 173-181 ◽  
Author(s):  
I. James Park ◽  
Lonnie S. Burnett ◽  
Howard W. Jones ◽  
Claude J. Migeon ◽  
Robert M. Blizzard
Keyword(s):  
Testosterone Level ◽  
Chromosome Complement ◽  
External Genitalia ◽  
Male Pseudohermaphroditism ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level ◽  
Stimulation Level ◽  
Level 3 ◽  
Low Testosterone

ABSTRACT A 27 year old female is described who had 46,XY chromosome complement, ambiguous external genitalia with elevated LH, slightly above normal FSH and low testosterone. Her plasma testosterone level increased 15–20 fold after HCG stimulation (5000 IU × 3). then returned to pre-stimulation level 3 months later. This was possibly due to the secretion of an abnormal LH molecule which is immunoreactive but biologically inactive in the human.

scholarly journals Erectile dysfunction and testosterone levels prior to COVID-19 disease: What is the relationship?

2021 ◽  
Vol 93 (4) ◽  
pp. 460-464
Author(s):  
Kadir Karkin ◽  
Ergün Alma
Keyword(s):  
Intensive Care ◽  
Erectile Dysfunction ◽  
Testosterone Level ◽  
Premature Ejaculation ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Testosterone Levels ◽  
Disease Prognosis ◽  
Before And After ◽  
The Relationship

Objective: We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Methods: Between April-December 2020, 70 patients who were admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for varicocele, premature ejaculation, and infertility reasons before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. The questionnaire was arranged to assess the first month before COVID-19 and after COVID-19. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated.Results: It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all patients were statisticaly and significantly different compared to the period before COVID-19 (p < 0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p < 0.05).Conclusions: Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease.

scholarly journals Testosterone Levels and Type 2 Diabetes—No Correlation with Age, Differential Predictive Value in Men and Women

Biomolecules ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 76 ◽  
Author(s):  
Mahir Karakas ◽  
Sarina Schäfer ◽  
Sebastian Appelbaum ◽  
Francisco Ojeda ◽  
Kari Kuulasmaa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Cross Sectional ◽  
Men And Women ◽  
Testosterone Levels ◽  
Increased Risk ◽  
Low Testosterone ◽  
Future Diabetes

Most studies reporting on the association of circulating testosterone levels with type 2 diabetes in men are of cross-sectional design. Reports on the relevance of altered testosterone levels in women are scarce. Here, we evaluate the role of low serum testosterone levels for incident diabetes in men and women in a population setting of 7706 subjects (3896 females). During a mean follow up time of 13.8 years, 7.8% developed type 2 diabetes. Significant correlations of testosterone with high density lipoprotein (HDL)-cholesterol (R = 0.21, p < 0.001), body-mass-index (R = −0.23, p < 0.001), and waist-to-hip-ratio (R = −0.21, p < 0.001) were found in men. No correlation was found with age in men; in women, the correlation was negligible (R = 0.04, p = 0.012). In men, low testosterone levels predicted high risk of type 2 diabetes, while in women this relationship was opposite. Men with low testosterone levels showed increased risk of future diabetes (hazard ratio (HR) 2.66, 95% confidence interval (CI) 1.91–3.72, p < 0.001 in basic model; HR 1.56 95%, CI 1.10–2.21, p = 0.003). In women, low testosterone levels indicated lower risk with (HR 0.53, 95% CI 0.37–0.77, p = 0.003), while the association lost significance in the fully adjusted model (HR 0.72, 95% CI 0.49–1.05, p = 0.09). Low levels of testosterone predicted future diabetes in men. A borderline opposite association was found in women.

THE EFFECT OF MAINTENANCE HAEMODIALYSIS AND RENAL TRANSPLANTATION ON THE PLASMA TESTOSTERONE LEVELS OF MALE PATIENTS IN CHRONIC RENAL FAILURE

1975 ◽  
Vol 80 (3) ◽  
pp. 577-582 ◽  
Author(s):  
J. Alaghband Zadeh ◽  
K. G. Koutsaimanis ◽  
A. P. Roberts ◽  
R. Curtis ◽  
J. R. Daly
Keyword(s):  
Renal Failure ◽  
Circadian Rhythm ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Testosterone Level ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Maintenance Haemodialysis ◽  
Male Patients

ABSTRACT Plasma testosterone levels were measured at the beginning of a 14 h period of haemodialysis, one hour later, midway through the period and at the end, in 18 male patients in chronic renal failure. The level fell from 8.70 ± 2.63 nmol/l at the start to 8.08 ± 3.33 nmol/l at the midpoint, and rose again to 10.12 ± 3.9 nmol/l at the end of a dialysis. All seven of the patients tested on a non-dialysis day showed similar levels at the same time. At the beginning of a 10 h dialysis period 19 other male patients showed a plasma testosterone level of 10.12 ± 3.99 nmol/l and, at the end, of 8.98 ± 4.54 nmol/l. Over the same period the plasma corticosteroids rose from 301 ± 101 nmol/l to 483 ± 199 nmol/l. Eight male patients who had had successful renal transplantation had plasma testosterone levels of 15.08 ± 7.49 nmol/l. It is concluded that the plasma testosterone is low in chronic renal failure, but the circadian rhythm is preserved. Treatment with maintenance haemodialysis does not itself affect the plasma testosterone level, or alter the circadian rhythm despite the procedure's being a stress. Successful renal transplantation restores the plasma testosterone to normal in most cases.

scholarly journals COVID-19 may cause Erectile Dysfunction (ED) and the high level of testosterone is associated with poor prognosis

2021 ◽  
Author(s):  
kadir karkin ◽  
ergün alma ◽  
Hakan Erçil ◽  
keremhan gözükara ◽  
ferhat ortaoğlu ◽  
...  
Keyword(s):  
Intensive Care ◽  
Erectile Dysfunction ◽  
Testosterone Level ◽  
Age Groups ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Age Group ◽  
Testosterone Levels ◽  
High Level ◽  
The Relationship

We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Between April-December 2020, 70 patients who admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for any reason before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. This questionnaire was arranged to present the first month before COVID-19 and after COVID-19. The patients were registered as 20-40 age group 1, 40-60 age group 2 and 60 years and above group 3. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated. It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all three groups were statisticaly and significantly different compared to the period before COVID-19 (p <0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p <0.05). Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease. Keywords COVID-19, erectile dysfunction, testosterone What’s already known about this topic? The relationship between Erectile Dysfunction (ED) and COVID-19 develops due to vasculogenic and hormonal causes which were caused by the primary disease. What does this article add? We showed with this study that COVID-19 causes ED in all age groups, reduces testosterone levels seriously. Moreover, we also presented that the higher the testosterone levels during COVID-19, the more severe the disease progresses.

scholarly journals SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking?

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Stephen J. Winters
Keyword(s):  
Testosterone Level ◽  
Clinical Condition ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Total Testosterone ◽  
Male Hypogonadism ◽  
Adult Onset ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
The Relationship

Abstract Background Adult onset male hypogonadism (AOH) is a common clinical condition whose diagnosis and management are controversial, and is often characterized by a low level of SHBG, but our understanding of why testosterone levels are low when SHBG is low is incomplete. Methods This retrospective chart review was performed to compare the relationship between SHBG and testosterone in the plasma of men presenting for evaluation of AOH with a cohort of men treated chronically with transdermal testosterone. Results The level of SHBG was < 30 nmol/L in 73% of men who presented for evaluation of AOH, and was inversely proportional to BMI in both the untreated and the testosterone-treated men. As in previous populations, the level of SHBG was highly positively correlated (r = 0.71, p < 0.01) with the total testosterone level in untreated men presenting for evaluation of AOH, but no relationship was found between the level of SHBG and total testosterone among men who were being treated with a transdermal testosterone preparation. Conclusions These findings further support the idea that SHBG regulates testicular negative feedback either directly or by modulating the entry of testosterone or estradiol into cells in the hypothalamus and/or pituitary to control gonadotropin synthesis and secretion which explains in part the low testosterone levels in men with AOH. Trial registration Not applicable

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