A CASE OF MALE PSEUDOHERMAPHRODITISM ASSOCIATED WITH ELEVATED LH, NORMAL FSH AND LOW TESTOSTERONE POSSIBLY DUE TO THE SECRETION OF AN ABNORMAL LH MOLECULE

1976 ◽  
Vol 83 (1) ◽  
pp. 173-181 ◽  
Author(s):  
I. James Park ◽  
Lonnie S. Burnett ◽  
Howard W. Jones ◽  
Claude J. Migeon ◽  
Robert M. Blizzard
Keyword(s):  
Testosterone Level ◽  
Chromosome Complement ◽  
External Genitalia ◽  
Male Pseudohermaphroditism ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level ◽  
Stimulation Level ◽  
Level 3 ◽  
Low Testosterone

ABSTRACT A 27 year old female is described who had 46,XY chromosome complement, ambiguous external genitalia with elevated LH, slightly above normal FSH and low testosterone. Her plasma testosterone level increased 15–20 fold after HCG stimulation (5000 IU × 3). then returned to pre-stimulation level 3 months later. This was possibly due to the secretion of an abnormal LH molecule which is immunoreactive but biologically inactive in the human.

scholarly journals Association of plasma total testosterone level and metabolic syndrome in adult males

2019 ◽  
Vol 9 (3) ◽  
pp. e27-e27
Author(s):  
Alireza Hejrati ◽  
Amir Ziaee ◽  
Mohammad Pourmahmudian ◽  
Elham Bayani ◽  
Mehrnaz Ghavamipour ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Testosterone Level ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Plasma Testosterone ◽  
Adult Males ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
The Relationship

Introduction: Low testosterone level has strongly been correlated with body fat accumulation and abdominal obesity in men. Objectives: This study aimed to evaluate testosterone level in men with and without metabolic syndrome to determine the relationship between testosterone and metabolic syndrome. Patients and Methods: This case-control study was conducted on 172 cases of metabolic syndrome and 172 participants as a control group in Rasoul Akram hospital, Tehran, Iran. Demographic characteristics, fasting blood sugar (FBS), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, triglyceride (TG), and testosterone levels were recorded. SPSS version 21.0 and SAS version 9.1 were used for statistical analysis. Level of significance was considered 0.05. Results: The mean age of the two groups were 45.1±9.3 years and 41.5 ±11.2 years, respectively. There was a significant difference in serum testosterone levels between both groups and low testosterone levels were associated with metabolic syndrome (P<0.001). Serum testosterone levels showed a significant negative correlation with age in the metabolic syndrome group (r= -0.16, P=0.02). The relationship between metabolic syndrome and total plasma testosterone level using logistic regression model showed that, by increasing the total plasma testosterone level, the odds ratio for metabolic syndrome was 0.076 (95% CI: 0.027-0.216; P< 0.001). Conclusion: According to the results, low level of testosterone was related to the presence of metabolic syndrome in adult males. Future studies can investigate diagnostic value of testosterone level in this syndrome.

Infantile acne associated with a high plasma testosterone level in a 21-month-old boy

1995 ◽  
Vol 33 (4) ◽  
pp. 676-678 ◽  
Author(s):  
Nobuko Tabata ◽  
Tadashi Terui ◽  
Mariko Watanabe ◽  
Hachiro Tagami
Keyword(s):  
Testosterone Level ◽  
High Plasma ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level

THE EFFECT OF CYPROTERONE ACETATE ON THE PLASMA GONADOTROPHIN RESPONSE TO GONADOTROPHIN RELEASING HORMONE

1976 ◽  
Vol 81 (3) ◽  
pp. 680-684 ◽  
Author(s):  
Richard A. Donald ◽  
Eric A. Espiner ◽  
R. John Cowles ◽  
Joy E. Fazackerley
Keyword(s):  
Testosterone Level ◽  
Cyproterone Acetate ◽  
Luteinising Hormone ◽  
Follicle Stimulating Hormone ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level ◽  
Releasing Hormone ◽  
Lh Release ◽  
Gonadotrophin Releasing Hormone ◽  
Male Patients

ABSTRACT Cyproterone acetate (100–150 mg daily) was administered to 8 male patients with excessive libido. Within 3 months a significant fall (P < 0.02) in plasma testosterone was demonstrated. The plasma luteinising hormone (LH) and follicle stimulating hormone (FSH) responses to gonadotrophin releasing hormone (LH/FSH-RH) were also significantly impaired (P < 0.05). A direct correlation between the resting plasma testosterone level and the LH response to LH/FSH-RH was demonstrated (r = 0.743). It is concluded that the fall in plasma testosterone levels in patients receiving cyproterone acetate may be attributed to suppression of LH release, rather than an antiandrogen effect on the testis or hypothalamus.

scholarly journals Male pseudohermaphroditism in dogs: three case reports

2008 ◽  
Vol 52 (No. 2) ◽  
pp. 74-78 ◽  
Author(s):  
M.R. Alam ◽  
Y.G. Cho ◽  
S.J. Cho ◽  
J.I. Lee ◽  
H.B. Lee ◽  
...  
Keyword(s):  
Undescended Testis ◽  
Case Reports ◽  
External Genitalia ◽  
Male Pseudohermaphroditism ◽  
Congenital Defects ◽  
Seminiferous Tubules ◽  
National University ◽  
Mullerian Ducts ◽  
Low Testosterone ◽  
Male Karyotype

Three Cocker Spaniel dogs, 2&minus;3 months old, weighing 3&minus;4 kg, were presented to the Chonbuk Animal Medical Centre, Chonbuk National University, with intersex anomalies. Physical, radiological, gross, histological, hormonal and cytogenetic studies were performed. Physical examination of the external genitalia revealed that the dogs possessed the vulva with an enlarged clitoris protruding from the vulvar juncture and the scrotum with an undescended testis in Case 1 and 2, and both testes remained undescended in Case 3. Hyperoestrogenaemia and low testosterone serum concentrations were found. Laparotomy revealed persistent Mullerian ducts (PMD) in Case 1 and 2, and abdominally located testicle(s) in all the cases. Histological examinations of the gonads revealed inactive seminiferous tubules. Cytogenetic analysis showed 78XY male karyotype in Case 1 and 2, whereas Case 3 showed 79XX female karyotype. The congenital defects were diagnosed as male pseudohermaphroditism (MPH) and PMD in Case 1 and 2, and XX sex reversal MPH in Case 3.

scholarly journals The Effect of Eurycoma longifolia on Sperm Quality of Male Rats

2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Kit-Lam Chan ◽  
Bin-Seng Low ◽  
Chin-Hoe Teh ◽  
Prashanta K. Das
Keyword(s):  
Testosterone Level ◽  
Sperm Quality ◽  
Sperm Count ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Seminiferous Tubules ◽  
Albino Rats ◽  
Meoh Extract ◽  
Plasma Testosterone Level ◽  
Etoac Fraction

The present study investigated the effects of a standardized methanol extract of E. longifolia Jack containing the major quassinoid constituents of 13α(21)-epoxyeurycomanone (1), eurycomanone (2), 13α,21-dihydroeurycomanone (3) and eurycomanol (4) on the epididymal spermatozoa profile of normal and Andrographis paniculata induced infertile rats. The standardized MeOH extract at doses of 50, 100 and 200 mg/kg, the EtOAc fraction (70 mg/kg), and standardized MeOH extract at 200 mg/kg co-administered with the EtOAc fraction of A. paniculata at 70 mg/kg were each given orally to male Sprague-Dawley albino rats for 48 consecutive days. The spermatozoa count, morphology, motility, plasma testosterone level and Leydig cell count of the animals were statistically analyzed by ANOVA with a post-hoc Tukey HSD test. The results showed that the sperm count of rats given the standardized MeOH extract alone at doses of 50, 100 and 200 mg/kg were increased by 78.9, 94.3 and 99.2 %, respectively when compared with that of control (p < 0.01). The low count, poor motility and abnormal morphology of the spermatozoa induced by the A. paniculata fraction were significantly reversed by the standardized MeOH extract of E. longifolia (p < 0.001). The plasma testosterone level of the rats treated with the standardized MeOH extract at 200 mg/kg was significantly increased (p < 0.01) when compared with that of the control and infertile animals. The spermatocytes in the seminiferous tubules and the Leydig cells appeared normal. Testosterone level was significantly higher in the testes (p < 0.01) than in the plasma after 30 days of oral treatment with the standardized MeOH extract. Interestingly, eurycomanone (2) alone was detected in the rat testis homogenates by HPLC-UV and confirmed by LC/MS, and may have contributed towards the improvement of sperm quality. Thus, the plant may potentially be suitable for the management of male infertility.

174 EFFECTS OF SMOKING ON PLASMA TESTOSTERONE LEVEL AND ERECTILE FUNCTION IN MALE RATS

2010 ◽  
Vol 9 (2) ◽  
pp. 86-87
Author(s):  
M.G. Park ◽  
K.W. Ko ◽  
M.M. Oh ◽  
D.K. Yoon ◽  
J.J. Kim ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Erectile Function ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level

Effect of ethyl alcohol on plasma testosterone level in mice

Steroids ◽  
1974 ◽  
Vol 23 (6) ◽  
pp. 921-928 ◽  
Author(s):  
Fouad M. Badr ◽  
Andrzej Bartke
Keyword(s):  
Ethyl Alcohol ◽  
Testosterone Level ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level
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