THE EFFECT OF MAINTENANCE HAEMODIALYSIS AND RENAL TRANSPLANTATION ON THE PLASMA TESTOSTERONE LEVELS OF MALE PATIENTS IN CHRONIC RENAL FAILURE

1975 ◽  
Vol 80 (3) ◽  
pp. 577-582 ◽  
Author(s):  
J. Alaghband Zadeh ◽  
K. G. Koutsaimanis ◽  
A. P. Roberts ◽  
R. Curtis ◽  
J. R. Daly
Keyword(s):  
Renal Failure ◽  
Circadian Rhythm ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Testosterone Level ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Maintenance Haemodialysis ◽  
Male Patients

ABSTRACT Plasma testosterone levels were measured at the beginning of a 14 h period of haemodialysis, one hour later, midway through the period and at the end, in 18 male patients in chronic renal failure. The level fell from 8.70 ± 2.63 nmol/l at the start to 8.08 ± 3.33 nmol/l at the midpoint, and rose again to 10.12 ± 3.9 nmol/l at the end of a dialysis. All seven of the patients tested on a non-dialysis day showed similar levels at the same time. At the beginning of a 10 h dialysis period 19 other male patients showed a plasma testosterone level of 10.12 ± 3.99 nmol/l and, at the end, of 8.98 ± 4.54 nmol/l. Over the same period the plasma corticosteroids rose from 301 ± 101 nmol/l to 483 ± 199 nmol/l. Eight male patients who had had successful renal transplantation had plasma testosterone levels of 15.08 ± 7.49 nmol/l. It is concluded that the plasma testosterone is low in chronic renal failure, but the circadian rhythm is preserved. Treatment with maintenance haemodialysis does not itself affect the plasma testosterone level, or alter the circadian rhythm despite the procedure's being a stress. Successful renal transplantation restores the plasma testosterone to normal in most cases.

THE EFFECT OF CYPROTERONE ACETATE ON THE PLASMA GONADOTROPHIN RESPONSE TO GONADOTROPHIN RELEASING HORMONE

1976 ◽  
Vol 81 (3) ◽  
pp. 680-684 ◽  
Author(s):  
Richard A. Donald ◽  
Eric A. Espiner ◽  
R. John Cowles ◽  
Joy E. Fazackerley
Keyword(s):  
Testosterone Level ◽  
Cyproterone Acetate ◽  
Luteinising Hormone ◽  
Follicle Stimulating Hormone ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level ◽  
Releasing Hormone ◽  
Lh Release ◽  
Gonadotrophin Releasing Hormone ◽  
Male Patients

ABSTRACT Cyproterone acetate (100–150 mg daily) was administered to 8 male patients with excessive libido. Within 3 months a significant fall (P < 0.02) in plasma testosterone was demonstrated. The plasma luteinising hormone (LH) and follicle stimulating hormone (FSH) responses to gonadotrophin releasing hormone (LH/FSH-RH) were also significantly impaired (P < 0.05). A direct correlation between the resting plasma testosterone level and the LH response to LH/FSH-RH was demonstrated (r = 0.743). It is concluded that the fall in plasma testosterone levels in patients receiving cyproterone acetate may be attributed to suppression of LH release, rather than an antiandrogen effect on the testis or hypothalamus.

PLASMA LEVELS OF TESTOSTERONE IN BULLS

1978 ◽  
Vol 88 (4) ◽  
pp. 787-792 ◽  
Author(s):  
Anne Sundby ◽  
P. A. Torjesen
Keyword(s):  
Testosterone Level ◽  
Plasma Levels ◽  
Leydig Cells ◽  
Sharp Decrease ◽  
Plasma Testosterone ◽  
Plasma Samples ◽  
Elevated Plasma ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Testosterone Production

ABSTRACT Administration of 6000 IU HCG to 4 bulls was followed by an elevation of plasma testosterone lasting for 9–13 days. When HCG administration was repeated, the testosterone response was shortened to 4–6 days in 3 bulls due to the formation of antibodies against HCG. The appearance of HCG antibodies coincided with a sharp decrease in the plasma testosterone level, indicating that Leydig cells have to be under continuous HCG stimulation to maintain increased testosterone production. No antibody against bovine LH was detected in the plasma samples containing antibodies against HCG. In one bull the response following the second HCG injection was similar to the plasma testosterone pattern following the first. No antibodies against HCG were found in this bull. Five bulls received 750 IU HCG twice. Following the period with elevated plasma testosterone levels, subnormal levels were observed after both injections. One injection led to decreased levels without development of antibodies against HCG while the second HCG injection led to subnormal testosterone levels concomitant with measurable antibodies against HCG.

Vitamin a and its Transport Proteins in Patients with Chronic Renal Failure Receiving Maintenance Haemodialysis and after Renal Transplantation

1983 ◽  
Vol 65 (6) ◽  
pp. 619-626 ◽  
Author(s):  
J. Kelleher ◽  
C. S. Humphrey ◽  
Dana Homer ◽  
A. M. Davison ◽  
G. R. Giles ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Vitamin A ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Retinol Binding Protein ◽  
Maintenance Haemodialysis ◽  
Protein Levels ◽  
Normal Individuals

1. Serum vitamin A, retinol binding protein, prealbumin and transferrin have been studied in chronic renal failure patients receiving maintenance haemodialysis and after renal transplantation. 2. Vitamin A and retinol binding protein were uniformly raised in haemodialysis patients and this was unrelated to the period on dialysis. There was a molar excess of retinol binding protein to both vitamin A and prealbumin as compared with normal individuals. 3. Renal transplantation significantly reduces serum vitamin A and retinol binding protein concentrations but has no effect on prealbumin concentrations. The reduction in vitamin A and retinol binding protein is variable in individual patients and cannot be predicted either by the allograft function or time since transplantation. 4. Several years after transplantation, with normal serum creatinine, both serum vitamin A and retinol binding protein levels may still be greatly increased. Despite the very high vitamin A and retinol binding protein concentrations, the close correlation between the two seen in normal individuals is well maintained. 5. The continuing high vitamin A and retinol binding protein levels in patients with satisfactorily functioning transplants is unexplained.

scholarly journals Association of plasma total testosterone level and metabolic syndrome in adult males

2019 ◽  
Vol 9 (3) ◽  
pp. e27-e27
Author(s):  
Alireza Hejrati ◽  
Amir Ziaee ◽  
Mohammad Pourmahmudian ◽  
Elham Bayani ◽  
Mehrnaz Ghavamipour ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Testosterone Level ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Plasma Testosterone ◽  
Adult Males ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
The Relationship

Introduction: Low testosterone level has strongly been correlated with body fat accumulation and abdominal obesity in men. Objectives: This study aimed to evaluate testosterone level in men with and without metabolic syndrome to determine the relationship between testosterone and metabolic syndrome. Patients and Methods: This case-control study was conducted on 172 cases of metabolic syndrome and 172 participants as a control group in Rasoul Akram hospital, Tehran, Iran. Demographic characteristics, fasting blood sugar (FBS), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, triglyceride (TG), and testosterone levels were recorded. SPSS version 21.0 and SAS version 9.1 were used for statistical analysis. Level of significance was considered 0.05. Results: The mean age of the two groups were 45.1±9.3 years and 41.5 ±11.2 years, respectively. There was a significant difference in serum testosterone levels between both groups and low testosterone levels were associated with metabolic syndrome (P<0.001). Serum testosterone levels showed a significant negative correlation with age in the metabolic syndrome group (r= -0.16, P=0.02). The relationship between metabolic syndrome and total plasma testosterone level using logistic regression model showed that, by increasing the total plasma testosterone level, the odds ratio for metabolic syndrome was 0.076 (95% CI: 0.027-0.216; P< 0.001). Conclusion: According to the results, low level of testosterone was related to the presence of metabolic syndrome in adult males. Future studies can investigate diagnostic value of testosterone level in this syndrome.

A Case of Living-Donor Renal Transplantation for Chronic Renal Failure Caused by Secondary Amyloidosis

2011 ◽  
Vol 43 (6) ◽  
pp. 2418-2420 ◽  
Author(s):  
K. Sakai ◽  
M. Okamoto ◽  
K. Koshino ◽  
T. Suzuki ◽  
S. Nobori ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Living Donor ◽  
Secondary Amyloidosis

Neuropeptide Y as a plasma marker for phaeochromocytoma, ganglioneuroblastoma and neuroblastoma

1992 ◽  
Vol 83 (2) ◽  
pp. 205-211 ◽  
Author(s):  
Toraichi Mouri ◽  
Masahiko Sone ◽  
Kazuhiro Takahashi ◽  
Keiichi Itoi ◽  
Kazuhito Totsune ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Neuropeptide Y ◽  
Healthy Adult ◽  
Plasma Samples ◽  
Normal Range ◽  
Maintenance Haemodialysis ◽  
Upper Limits ◽  
Highly Sensitive ◽  
Plasma Marker

1. We investigated the usefulness of neuropeptide Y as a plasma marker for phaeochromocytoma, ganglioneuroblastoma and neuroblastoma using a simple and highly sensitive r.i.a. for human neuropeptide Y. 2. Plasma immunoreactive neuropeptide Y concentrations were measured without extraction in plasma samples (100 μl) from patients with various diseases. 3. The plasma immunoreactive neuropeptide Y concentration in patients with phaeochromocytoma (172.3 ± 132.4 pmol/l, mean ± sd, n = 23) was significantly higher than that in healthy adult subjects (40.1 ± 10.1 pmol/l, n = 40, P<0.0001). The plasma immunoreactive neuropeptide Y concentrations in patients with ganglioneuroblastoma (590.7 ± 563.6 pmol/l, n = 6) and patients with neuroblastoma (566.9 ± 524.4 pmol/l, n = 15) were significantly higher than those in control children (1–9 years old, 82.2 ± 39.9 pmol/l, n = 72, P<0.0001). 4. The plasma immunoreactive neuropeptide Y concentration in patients with essential hypertension (34.0 ± 3.7 pmol/l, n = 18) was within the normal range, but in patients with chronic renal failure undergoing maintenance haemodialysis (192.1 ± 68.0 pmol/l, n = 25) and in non-dialysed patients with chronic renal failure (85.1 ± 23.1 pmol/l, n = 7) it was significantly higher than that in healthy adult subjects (P<0.0001). 5. Eighty-seven per cent of the patients with phaeochromocytoma, 67% of the patients with ganglioneuroblastoma and 80% of the patients with neuroblastoma showed plasma immunoreactive neuropeptide Y concentrations higher than the upper limits in the control subjects [62 pmol/l (adult) and 160 pmol/l (children)]. 6. These results suggest that neuropeptide Y is a useful plasma marker for these tumours in addition to other factors unless the patients have renal failure.

High Prevalence of Hypogonadism in Male Patients with Chronic Renal Failure

2011 ◽  
pp. P3-215-P3-215
Author(s):  
Walter Reinhardt ◽  
Vasili Bouronikou ◽  
Sebastian Dolff ◽  
Martina Broecker ◽  
Klaus Mann ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
High Prevalence ◽  
Male Patients

Infantile acne associated with a high plasma testosterone level in a 21-month-old boy

1995 ◽  
Vol 33 (4) ◽  
pp. 676-678 ◽  
Author(s):  
Nobuko Tabata ◽  
Tadashi Terui ◽  
Mariko Watanabe ◽  
Hachiro Tagami
Keyword(s):  
Testosterone Level ◽  
High Plasma ◽  
Plasma Testosterone ◽  
Plasma Testosterone Level
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