scholarly journals Malignant Melanoma Metastasis to the Appendix as the First Presentation of Lentigo Maligna Melanoma

2021 ◽  
Vol 24 (4) ◽  
pp. 330-332
Author(s):  
Shokouh Taghipour Zahir ◽  
Koorosh Rahmani ◽  
Seyed Abolfazl Hosseini
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Metastasis ◽  
Lentigo Maligna ◽  
Lentigo Maligna Melanoma

Lentigo Maligna Melanoma

1978 ◽  
Vol 86 (5) ◽  
pp. ORL-743-ORL-746 ◽  
Author(s):  
Fred J. Stucker
Keyword(s):  
Elderly Patient ◽  
Malignant Melanoma ◽  
Good Prognosis ◽  
Premalignant Lesion ◽  
Diagnosis And Treatment ◽  
Lentigo Maligna ◽  
Clinical Pattern ◽  
Lentigo Maligna Melanoma ◽  
Proper Diagnosis ◽  
Slow Growing

Lentigo maligna melanoma is a malignant melanoma with a recognizable clinical pattern. It is a slow-growing, pigmented tumor evolving from a premalignant lesion on the exposed cutaneous surface of an elderly patient. Histologically, it is marked by pleomorphism of melanocytes with evidence of invasion. A case is presented demonstrating the features of this malignant melanoma with an exceptionally good prognosis. The importance of the clinical and histologic correlation is emphasized to ensure proper diagnosis and treatment.

Pagetoid malignant melanoma and lentigo maligna melanoma of toe

1978 ◽  
Vol 262 (3) ◽  
pp. 275-283 ◽  
Author(s):  
Takafumi Morishima ◽  
Toyonaga Ishikawa ◽  
Mikio Endo ◽  
Yoshiaki Tsujiguchi
Keyword(s):  
Malignant Melanoma ◽  
Lentigo Maligna ◽  
Lentigo Maligna Melanoma

scholarly journals Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion

2017 ◽  
Vol 5 (4) ◽  
pp. 458-461 ◽  
Author(s):  
Uwe Wollina ◽  
Gesina Hansel ◽  
Nadine Schmidt ◽  
Jacqueline Schönlebe ◽  
Thomas Kittner ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Three Dimensional ◽  
Surgical Excision ◽  
Lentigo Maligna ◽  
Skull Roof ◽  
Complete Surgical Excision ◽  
Lentigo Maligna Melanoma ◽  
First Relapse ◽  
One Year ◽  
Serial Excision

BACKGROUND: Lentigo malignant melanoma is a melanoma subtype of chronic sun-damaged skin in elderly Caucasians. Amelanotic variants of lentigo malignant are extremely rare.CASE PRESENTATION: This is a case report of an 80-year-old male patient who presented with a non-pigmented exophytic tumour of his bald head. After complete surgical excision under the suspicion of squamous cell carcinoma, three-dimensional histologic examination confirmed an amelanotic lentigo malignant melanoma with a tumour thickness of 1.76 mm, resected R0. Five years later he developed the first relapse, the other year a satellite metastasis was surgically removed. One year later, this patient had developed a large relapsing lentigo malignant melanoma with skull roof invasion. There was no evidence of distant metastatic spread. Amelanotic lentigo malignant melanoma is a very rare tumour.CONCLUSIONS: Serial excision or slow Mohs and Mohs micrographic surgery are the treatments of choice especially in the head and neck area. These tumours may be locally very aggressive as it is shown by skull invasion in the present case.

scholarly journals Chondrosarcomatous Differentiation in a Large Malignant Melanoma of the Scalp

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Colin S. Alderson ◽  
Helen E. Douglas ◽  
Rebecca Rollett ◽  
Bipin Mathew ◽  
Paolo Matteucci
Keyword(s):  
Malignant Melanoma ◽  
Female Patient ◽  
Delayed Diagnosis ◽  
Primary Resection ◽  
Metastatic Spread ◽  
Patient Treatment ◽  
Lentigo Maligna ◽  
Rare Phenomenon ◽  
Divergent Differentiation ◽  
Lentigo Maligna Melanoma

Background. Divergent differentiation in malignant melanoma is a rare phenomenon, which can lead to delayed diagnosis or misdiagnosis, impacting upon patient treatment and outcome, as well as the understanding of tumour behaviour. Case. We present the case of a large long-standing tumour on the scalp of a 72-year-old female patient, which when excised and examined histologically was revealed to be a nodular malignant melanoma displaying chondrosarcomatous differentiation. Foci suggestive of lentigo maligna were also present. Rapid metastatic spread of the tumour was observed shortly after the primary resection. Discussion. To our knowledge, this is the first reported case in the literature of chondrosarcomatous differentiation in a lentigo maligna melanoma. The clinical and histopathological details and images of this case are presented alongside a discussion regarding such tumours and patterns of similar tumour behaviour.

scholarly journals Deuterium Oxide (D2O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 605
Author(s):  
Jana Jandova ◽  
Anh B. Hua ◽  
Jocelyn Fimbres ◽  
Georg T. Wondrak
Keyword(s):  
Gene Expression ◽  
Stress Response ◽  
Malignant Melanoma ◽  
Tumor Growth ◽  
Deuterium Oxide ◽  
Human Melanoma ◽  
Pharmacological Intervention ◽  
Melanoma Metastasis ◽  
Response Gene ◽  
Stress Response Gene

There are two stable isotopes of hydrogen, protium (1H) and deuterium (2H; D). Cellular stress response dysregulation in cancer represents both a major pathological driving force and a promising therapeutic target, but the molecular consequences and potential therapeutic impact of deuterium (2H)-stress on cancer cells remain largely unexplored. We have examined the anti-proliferative and apoptogenic effects of deuterium oxide (D2O; ‘heavy water’) together with stress response gene expression profiling in panels of malignant melanoma (A375V600E, A375NRAS, G361, LOX-IMVI), and pancreatic ductal adenocarcinoma (PANC-1, Capan-2, or MIA PaCa-2) cells with inclusion of human diploid Hs27 skin fibroblasts. Moreover, we have examined the efficacy of D2O-based pharmacological intervention in murine models of human melanoma tumor growth and metastasis. D2O-induction of apoptosis was substantiated by AV-PI flow cytometry, immunodetection of PARP-1, and pro-caspase 3 cleavage, and rescue by pan-caspase inhibition. Differential array analysis revealed early modulation of stress response gene expression in both A375 melanoma and PANC-1 adenocarcinoma cells elicited by D2O (90%; ≤6 h) (upregulated: CDKN1A, DDIT3, EGR1, GADD45A, HMOX1, NFKBIA, or SOD2 (up to 9-fold; p < 0.01)) confirmed by independent RT-qPCR analysis. Immunoblot analysis revealed rapid onset of D2O-induced stress response phospho-protein activation (p-ERK, p-JNK, p-eIF2α, or p-H2AX) or attenuation (p-AKT). Feasibility of D2O-based chemotherapeutic intervention (drinking water (30% w/w)) was demonstrated in a severe combined immunodeficiency (SCID) mouse melanoma metastasis model using luciferase-expressing A375-Luc2 cells. Lung tumor burden (visualized by bioluminescence imaging) was attenuated by D2O, and inhibition of invasiveness was also confirmed in an in vitro Matrigel transwell invasion assay. D2O supplementation also suppressed tumor growth in a murine xenograft model of human melanoma, and median survival was significantly increased without causing adverse effects. These data demonstrate for the first time that systemic D2O administration impairs growth and metastasis of malignant melanoma through the pharmacological induction of deuterium (2H)-stress.

scholarly journals Impaired Alignment of Bone Matrix Microstructure Associated with Disorganized Osteoblast Arrangement in Malignant Melanoma Metastasis

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 131
Author(s):  
Aira Matsugaki ◽  
Yumi Kimura ◽  
Ryota Watanabe ◽  
Fumihito Nakamura ◽  
Ryo Takehana ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cell Activation ◽  
Ex Vivo ◽  
Bone Matrix ◽  
Melanoma Metastasis ◽  
Mineral Density ◽  
High Fracture ◽  
Matrix Microstructure ◽  
Metastasis Model

Malignant melanoma favors spreading to bone, resulting in a weakened bone with a high fracture risk. Here, we revealed the disorganized alignment of apatite crystals in the bone matrix associated with the homing of cancer cells by developing an artificially controlled ex vivo melanoma bone metastasis model. The ex vivo metastasis model reflects the progressive melanoma cell activation in vivo, resulting in decreased bone mineral density and expression of MMP1-positive cells. Moreover, less organized intercellular connections were observed in the neighboring osteoblasts in metastasized bone, indicating the abnormal and randomized organization of bone matrix secreted by disconnected osteoblasts. Our study revealed that the deteriorated microstructure associated with disorganized osteoblast arrangement was a determinant of malignant melanoma-related bone dysfunction.

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