scholarly journals Comparison between lentigo maligna melanoma and other histogenetic types of malignant melanoma of the head and neck

1996 ◽  
Vol 73 (7) ◽  
pp. 940-944 ◽  
Author(s):  
NH Cox ◽  
◽  
TC Aitchison ◽  
JM Sirel ◽  
RM MacKie
Keyword(s):  
Malignant Melanoma ◽  
Head And Neck ◽  
Lentigo Maligna ◽  
Lentigo Maligna Melanoma

scholarly journals Lentigo Maligna Melanoma of the Head and Neck

1993 ◽  
Vol 103 (5) ◽  
pp. 520???524 ◽  
Author(s):  
F. P. Johns Langford ◽  
Samuel R. Fisher ◽  
David W. Molter ◽  
Hilliard F. Seigler
Keyword(s):  
Head And Neck ◽  
Lentigo Maligna ◽  
Lentigo Maligna Melanoma

scholarly journals Malignant Melanoma Metastasis to the Appendix as the First Presentation of Lentigo Maligna Melanoma

2021 ◽  
Vol 24 (4) ◽  
pp. 330-332
Author(s):  
Shokouh Taghipour Zahir ◽  
Koorosh Rahmani ◽  
Seyed Abolfazl Hosseini
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Metastasis ◽  
Lentigo Maligna ◽  
Lentigo Maligna Melanoma

Considerations for Timing of Defect Reconstruction in Cutaneous Melanoma of the Head and Neck

2019 ◽  
Vol 35 (04) ◽  
pp. 404-409 ◽  
Author(s):  
Arya W. Namin ◽  
Georgeanne E. Cornell ◽  
Emily H. Smith ◽  
Robert P. Zitsch
Keyword(s):  
Head And Neck ◽  
Local Excision ◽  
Cutaneous Melanoma ◽  
Wide Local Excision ◽  
Tumor Thickness ◽  
Margin Status ◽  
Lentigo Maligna ◽  
Positive Margins ◽  
Lentigo Maligna Melanoma ◽  
Delayed Reconstruction

AbstractThe objective of this study is to identify the incidence and characteristics of cases with positive margins on wide local excision for cutaneous melanoma of the head and neck (CMHN) and therefore provide a potential basis for selectively delaying reconstruction pending final histological clearance of melanoma. A systematic review of English language articles was performed on studies retrieved from PubMed and Web of Science. Original investigations published between July 1999 and June 2018 reporting on margin status of CMHN wide local excision specimens were included in the review. The incidence of positive margins after definitive resection for cutaneous melanoma in the literature ranges from 6 to 20.9%. The incidence is higher in cases of advanced patient age, diagnosis by shave biopsy, lentigo maligna melanoma subtype, desmoplastic subtype, tumor thickness, and ulceration. Delayed reconstruction remains the most oncologically sound decision, allowing for interpretation of margin status on paraffin-embedded tissue sections. However, resection and the resultant defect closure in a single stage is more expedient and potentially a more efficient use of resources. The risk–benefit ratio of immediate versus delayed reconstruction must be considered for each case. The incidence of positive margins is higher in cases of advanced patient age, diagnosis by shave biopsy, lentigo maligna melanoma subtype, desmoplastic subtype, increasing tumor thickness, and the presence of ulceration; delayed reconstruction should be strongly considered in these cases.

Lentigo Maligna Melanoma

1978 ◽  
Vol 86 (5) ◽  
pp. ORL-743-ORL-746 ◽  
Author(s):  
Fred J. Stucker
Keyword(s):  
Elderly Patient ◽  
Malignant Melanoma ◽  
Good Prognosis ◽  
Premalignant Lesion ◽  
Diagnosis And Treatment ◽  
Lentigo Maligna ◽  
Clinical Pattern ◽  
Lentigo Maligna Melanoma ◽  
Proper Diagnosis ◽  
Slow Growing

Lentigo maligna melanoma is a malignant melanoma with a recognizable clinical pattern. It is a slow-growing, pigmented tumor evolving from a premalignant lesion on the exposed cutaneous surface of an elderly patient. Histologically, it is marked by pleomorphism of melanocytes with evidence of invasion. A case is presented demonstrating the features of this malignant melanoma with an exceptionally good prognosis. The importance of the clinical and histologic correlation is emphasized to ensure proper diagnosis and treatment.

Positive Margins in Cutaneous Melanoma of the Head and Neck: Implications for Timing of Reconstruction

2020 ◽  
pp. 019459982096917
Author(s):  
Arya W. Namin ◽  
Lauren Welby ◽  
Austin T. Baker ◽  
Laura M. Dooley
Keyword(s):  
Surgical Treatment ◽  
Head And Neck ◽  
Cutaneous Melanoma ◽  
Spindle Cell ◽  
National Cancer Database ◽  
Clinicopathologic Features ◽  
Lentigo Maligna ◽  
Positive Margins ◽  
Lentigo Maligna Melanoma ◽  
The Face

Objective The aim of this study is to identify clinicopathologic features associated with positive margins after surgical treatment of cutaneous melanoma of the head and neck (CMHN). Study Design Retrospective cohort study. Setting National Cancer Database. Methods A retrospective analysis of the National Cancer Database was performed of patients diagnosed with CMHN between 2004 and 2016. Univariate and multivariate analyses examining the association of clinicopathologic features with positive margins were performed via logistic regression analysis. Results A total of 101,560 patients met inclusion criteria. The incidence of positive margins was 5.0% (5128/101,560). Patients were significantly more likely to have positive margins with the following: increasing age ( P < .001; odds ratio [OR], 1.028; 95% CI, 1.026-1.031), the lip subsite ( P < .001; OR, 1.664; 95% CI, 1.286-2.154), the eyelid subsite ( P < .001; OR, 2.380; 95% CI, 1.996-2.838), the face subsite ( P < .001; OR, 1.215; 95% CI, 1.133-1.302), the lentigo maligna/lentigo maligna melanoma subtype ( P = .019; OR, 1.099; 95% CI, 1.016-1.188), the desmoplastic subtype ( P < .001; OR, 1.455; 95% CI, 1.261-1.680), the spindle cell subtype ( P = .006; OR, 1.276; 95% CI, 1.073-1.516), and advanced pT classification. Patients with male sex ( P < .001; OR, 0.733; 95% CI, 0.687-0.782) and without ulceration ( P < .001; OR, 0.803; 95% CI, 0.736-0.876) were significantly less likely to have positive margins. Conclusion The following have been identified as clinicopathologic features associated with positive margins after surgical treatment of CMHN: increasing age, female sex, the lip subsite, the eyelid subsite, the face subsite, ulceration, the lentigo maligna/lentigo maligna melanoma subtype, the desmoplastic subtype, the spindle cell subtype, and increasing pT classification.

scholarly journals The radiotherapy of lentigo maligna and lentigo maligna melanoma of the head and neck

Cancer ◽  
1980 ◽  
Vol 45 (9) ◽  
pp. 2279-2283 ◽  
Author(s):  
Frank Dancuart ◽  
Andrew R. Harwood ◽  
Peter J. Fitzpatrick
Keyword(s):  
Head And Neck ◽  
Lentigo Maligna ◽  
Lentigo Maligna Melanoma

scholarly journals Epidemiological aspects of melanoma at a university hospital dermatology center over a period of 20 years

2013 ◽  
Vol 88 (3) ◽  
pp. 344-353 ◽  
Author(s):  
Flavia Vieira Brandao ◽  
Ana Francisca Junqueira Ribeiro Pereira ◽  
Bernardo Gontijo ◽  
Flavia Vasques Bittencourt
Keyword(s):  
Head And Neck ◽  
Hospital Setting ◽  
Histological Type ◽  
University Hospital ◽  
Lentigo Maligna ◽  
Risk Of Death ◽  
Skin Cancers ◽  
Lentigo Maligna Melanoma ◽  
History Of ◽  
Level Of Significance

BACKGROUND: The incidence of melanoma has been steadily rising in past decades. Although it accounts for only 3% of all skin cancers, it is responsible for 75% of deaths. OBJECTIVE: to describe the epidemiological aspects of melanoma in a university hospital setting over a period of 20 years. METHODS: A total of 166 patients were analyzed between January 1990 and January 2010 for clinical and histological variables and correlations between them. A 5% level of significance was adopted. RESULTS: The majority of patients were Caucasians (74%), females (61%), with a mean age at diagnosis of 55. The predominant histological type was lentigo maligna/lentigo maligna melanoma (35.7%) and the head and neck was the most affected site (30.7%). Among non-Caucasians, the acral region was the most affected. Most tumors were in situ (41.1%). Growth of the lesion was the most frequent complaint (58.1%) and bleeding was most frequently associated with melanomas with a depth > 4mm. There were seven deaths (4.2%), with a high risk among men, non-Caucasians and those under 20 years of age, with a Breslow's depth > 2mm, with lentiginous acral melanoma and with a history of growth and bleeding. CONCLUSIONS: Our sample differs from most of the studies in the predominant location (head and neck), histological type (lentigo maligna/ lentigo maligna melanoma) and a major risk of death under the age of 20, which could be with a reflex of regional variation. Broader studies are necessary for validation of the results.

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