scholarly journals Low-Temperature Photothermal Therapy: Strategies and Applications

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-38
Author(s):  
Xiulin Yi ◽  
Qiu-Yi Duan ◽  
Fu-Gen Wu
Keyword(s):  
Low Temperature ◽  
Photothermal Therapy ◽  
Combined Treatments ◽  
Excellent Performance ◽  
Cancer Treatments ◽  
Future Directions ◽  
Excessive Heat ◽  
Therapeutic Modalities ◽  
Therapy Strategies ◽  
Mild Temperature

Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.

scholarly journals Nanomedicine-enabled chemotherapy-based synergetic cancer treatments

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Wencheng Wu ◽  
Yinying Pu ◽  
Jianlin Shi
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Application ◽  
Research Area ◽  
Chemotherapeutic Agents ◽  
Therapeutic Modality ◽  
Toxic Substances ◽  
Cancer Treatments ◽  
Therapeutic Modalities ◽  
Malignant Solid Tumor ◽  
Underlying Mechanisms

AbstractChemotherapy remains one of the most prevailing regimens hitherto in the fight against cancer, but its development has been being suffering from various fatal side effects associated with the non-specific toxicity of common chemical drugs. Advances in biomedical application of nanomedicine have been providing alternative but promising approaches for cancer therapy, by leveraging its excellent intrinsic physicochemical properties to address these critical concerns. In particular, nanomedicine-enabled chemotherapy has been established as a safer and promising therapeutic modality, especially the recently proposed nanocatalytic medicine featuring the capabilities to generate toxic substances by initiating diverse catalytic reactions within the tumor without directly relying on highly toxic but non-selective chemotherapeutic agents. Of special note, under exogenous/endogenous stimulations, nanomedicine can serve as a versatile platform that allows additional therapeutic modalities (photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), etc.) to be seamlessly integrated with chemotherapy for efficacious synergistic treatments of tumors. Here, we comprehensively review and summarize the representative studies of multimodal synergistic cancer treatments derived from nanomedicine and nanocatalytic medicine-enabled chemotherapy in recent years, and their underlying mechanisms are also presented in detail. A number of existing challenges and further perspectives for nanomedicine-synergized chemotherapy for malignant solid tumor treatments are also highlighted for understanding this booming research area as comprehensively as possible. Graphical Abstract

NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy

2020 ◽  
Author(s):  
zhihong sun ◽  
Guanjun Deng ◽  
Xinghua Peng ◽  
Xiuli Xu ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Photothermal Therapy ◽  
Whole Body ◽  
Mature Dendritic Cell ◽  
Immune Microenvironment ◽  
Highly Efficient ◽  
Tumor Immune Microenvironment ◽  
Shock Proteins ◽  
Mild Temperature ◽  
Broad Interest

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

Leukemia Support Groups: How Are They Doing?

1997 ◽  
Vol 4 (5) ◽  
pp. 407-412
Author(s):  
Donna Corwin Moss
Keyword(s):  
Quality Of Life ◽  
Support Groups ◽  
Age Groups ◽  
Cancer Treatments ◽  
Future Directions ◽  
Course Of Illness ◽  
New Concepts ◽  
Sources Of Support ◽  
Practical Impact

Background Support groups help their participants to cope with the emotional and practical impact of their illnesses. Methods The effectiveness of the Leukemia Society of America support groups in enhancing the quality of life for their participants is reviewed. The groundwork, purpose, and structure of such groups, as well as alternate sources of support, are presented. Evaluation and future directions for oncology groupwork are discussed. Results Support groups complement the therapies provided by clinical practitioners and scientists by addressing the additional needs of cancer patients over the course of illness and survival. Conclusions New concepts and methods that address the needs of specific age-groups and incorporate the newly generated data on cancer treatments will further enhance the benefits provided by support groups.

scholarly journals Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions

2021 ◽  
Vol 20 ◽  
pp. 483-496
Author(s):  
Mitchel J.R. Ruigrok ◽  
Henderik W. Frijlink ◽  
Barbro N. Melgert ◽  
Peter Olinga ◽  
Wouter L.J. Hinrichs
Keyword(s):  
Gene Therapy ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Future Directions ◽  
Recent Advances ◽  
Therapy Strategies

Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy

2021 ◽  
Author(s):  
Qiaoqiao Sun ◽  
Kun Tang ◽  
Liqun Song ◽  
Yanhua Li ◽  
Wei Pan ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Mild Temperature ◽  
Organic Framework

Photothermal therapy effectively ablate tumor by the hyperthermia (>50 °C), which was caused by laser irradiation. However, the hyperthermia may inevitably diffuse to the surrounding healthy tissues and induce additional...

Fabrication of pH Responsive Core-Shell Nanosystem with Low-Temperature Photothermal Therapy Effect for Treating Bacterial Biofilm Infection

2021 ◽  
Author(s):  
Dan Peng ◽  
Genhua Liu ◽  
Ye He ◽  
Pengfei Gao ◽  
Shuangquan Gou ◽  
...  
Keyword(s):  
Low Temperature ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Bacterial Biofilm ◽  
Alternative Strategy ◽  
Viable Alternative ◽  
Core Shell ◽  
Ph Responsive ◽  
Therapy Effect ◽  
Biofilm Infection

Recently, photothermal therapy (PTT) has been recognized as a viable alternative strategy against bacterial biofilm infection. However, hyperthermia required for PTT to ablate biofilm usually induced damage of normal tissue/organ...

1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy

2017 ◽  
Vol 29 (40) ◽  
pp. 1703588 ◽  
Author(s):  
Yu Yang ◽  
Wenjun Zhu ◽  
Ziliang Dong ◽  
Yu Chao ◽  
Lai Xu ◽  
...  
Keyword(s):  
Low Temperature ◽  
Coordination Polymer ◽  
Photothermal Therapy ◽  
Polymer Nanofibers ◽  
1D Coordination Polymer
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