Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy

2021 ◽  
Author(s):  
Qiaoqiao Sun ◽  
Kun Tang ◽  
Liqun Song ◽  
Yanhua Li ◽  
Wei Pan ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Mild Temperature ◽  
Organic Framework

Photothermal therapy effectively ablate tumor by the hyperthermia (>50 °C), which was caused by laser irradiation. However, the hyperthermia may inevitably diffuse to the surrounding healthy tissues and induce additional...

scholarly journals A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy

2020 ◽  
Vol 8 (25) ◽  
pp. 5451-5459 ◽  
Author(s):  
Ying Zhou ◽  
Sainan Liu ◽  
Chunling Hu ◽  
Lihan Cai ◽  
Maolin Pang
Keyword(s):  
Photodynamic Therapy ◽  
Local Recurrence ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Primary Tumors ◽  
Treatment Methods ◽  
Covalent Organic Framework ◽  
Organic Framework

As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence.

Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy

ACS Nano ◽  
2019 ◽  
Vol 13 (11) ◽  
pp. 13304-13316 ◽  
Author(s):  
Qun Guan ◽  
Le-Le Zhou ◽  
Yan-An Li ◽  
Wen-Yan Li ◽  
Shumei Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Organic Framework

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

Template-free synthesis and metalation of hierarchical covalent organic framework spheres for photothermal therapy

2019 ◽  
Vol 55 (95) ◽  
pp. 14315-14318 ◽  
Author(s):  
Yanshu Shi ◽  
Sainan Liu ◽  
Zhixiang Zhang ◽  
Ying Liu ◽  
Maolin Pang
Keyword(s):  
Photothermal Therapy ◽  
Room Temperature ◽  
Covalent Organic Framework ◽  
Template Free ◽  
Organic Framework

Room temperature synthesized hierarchical COF spheres were metalated with Fe3+ and utilized for photothermal therapy.

Cell membrane-anchoring covalent organic framework nanosheets for single-laser-triggered synergistic tumor therapy

2021 ◽  
Author(s):  
Yuanyuan Chen ◽  
Tong Wu ◽  
Shujie Liu ◽  
Wei Pan ◽  
Na Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Laser Irradiation ◽  
Tumor Therapy ◽  
Covalent Organic Framework ◽  
Single Laser ◽  
Membrane Anchoring ◽  
Organic Framework

Herein, pH low insertion peptide (pHLIP) engineered covalent organic framework nanosheets (COF NSs) were developed for cell membrane-anchoring synergistic tumor therapy under single laser irradiation.

Integration of a highly monodisperse covalent organic framework photosensitizer with cation exchange synthesized Ag2Se nanoparticles for enhanced phototherapy

2019 ◽  
Vol 55 (62) ◽  
pp. 9164-9167 ◽  
Author(s):  
Chunling Hu ◽  
Lihan Cai ◽  
Sainan Liu ◽  
Maolin Pang
Keyword(s):  
Cation Exchange ◽  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Se Nanoparticles ◽  
Organic Framework

COF–Ag2Se nanoparticles were synthesized via a cation exchange approach and utilized for combined photodynamic and photothermal therapy.

Fluorescence-enhanced covalent organic framework nanosystem for tumor imaging and photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (21) ◽  
pp. 10429-10438 ◽  
Author(s):  
Yang Liu ◽  
Yapei Zhang ◽  
Xiaomin Li ◽  
Xuefeng Gao ◽  
Xiaoyan Niu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Ph Responsive ◽  
Covalent Organic Framework ◽  
Enhanced Imaging ◽  
Organic Framework

Fluorescence-enhanced imaging and photothermal therapy based on pH-responsive covalent organic framework nanoplatform.

A carbon nanomaterial derived from a nanoscale covalent organic framework for photothermal therapy in the NIR-II biowindow

2020 ◽  
Vol 56 (56) ◽  
pp. 7793-7796 ◽  
Author(s):  
Qun Guan ◽  
Le-Le Zhou ◽  
Li-Na Zhou ◽  
Mengdi Li ◽  
Guo-Xin Qin ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Carbon Nanoparticles ◽  
Carbon Nanomaterial ◽  
Covalent Organic Framework ◽  
Highly Efficient ◽  
Organic Framework

A nanoscale carbon nanomaterial was synthesized through pyrolysis of its NCOF precursor, and the obtained carbon nanoparticles (CNPs) can be highly efficient NIR-II photothermal agents for antitumor treatment via PTT.

Tuning the pore structures and photocatalytic properties of a 2D covalent organic framework with multi-branched photoactive moieties

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16136-16142
Author(s):  
Xuan Wang ◽  
Ming-Jie Dong ◽  
Chuan-De Wu
Keyword(s):  
Photocatalytic Properties ◽  
Effective Strategy ◽  
Covalent Organic Framework ◽  
Highly Efficient ◽  
Pore Structures ◽  
Local Connection ◽  
Organic Framework

An effective strategy to incorporate accessible metalloporphyrin photoactive sites into 2D COFs by establishing a 3D local connection for highly efficient photocatalysis was developed.

NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy

2020 ◽  
Author(s):  
zhihong sun ◽  
Guanjun Deng ◽  
Xinghua Peng ◽  
Xiuli Xu ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Photothermal Therapy ◽  
Whole Body ◽  
Mature Dendritic Cell ◽  
Immune Microenvironment ◽  
Highly Efficient ◽  
Tumor Immune Microenvironment ◽  
Shock Proteins ◽  
Mild Temperature ◽  
Broad Interest

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

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