Fabrication of pH Responsive Core-Shell Nanosystem with Low-Temperature Photothermal Therapy Effect for Treating Bacterial Biofilm Infection

2021 ◽  
Author(s):  
Dan Peng ◽  
Genhua Liu ◽  
Ye He ◽  
Pengfei Gao ◽  
Shuangquan Gou ◽  
...  
Keyword(s):  
Low Temperature ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Bacterial Biofilm ◽  
Alternative Strategy ◽  
Viable Alternative ◽  
Core Shell ◽  
Ph Responsive ◽  
Therapy Effect ◽  
Biofilm Infection

Recently, photothermal therapy (PTT) has been recognized as a viable alternative strategy against bacterial biofilm infection. However, hyperthermia required for PTT to ablate biofilm usually induced damage of normal tissue/organ...

Highly efficient sunitinib release from pH-responsive mHPMC@Chitosan core-shell nanoparticles

2021 ◽  
Vol 258 ◽  
pp. 117719
Author(s):  
Hessam Jafari ◽  
Gholam Reza Mahdavinia ◽  
Bagher Kazemi ◽  
Hermann Ehrlich ◽  
Yvonne Joseph ◽  
...  
Keyword(s):  
Core Shell ◽  
Ph Responsive ◽  
Shell Nanoparticles ◽  
Highly Efficient ◽  
Core Shell Nanoparticles

ZnxMn1–XFe2O4@SiO2:zNd3+ Core–Shell Nanoparticles for Low-Field Magnetic Hyperthermia and Enhanced Photothermal Therapy with the Potential for Nanothermometry

2021 ◽  
Vol 4 (2) ◽  
pp. 2190-2210
Author(s):  
Marcus Vinícius-Araújo ◽  
Navadeep Shrivastava ◽  
Ailton A. Sousa-Junior ◽  
Sebastiao A. Mendanha ◽  
Ricardo Costa De Santana ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Magnetic Hyperthermia ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Low Field ◽  
Core Shell Nanoparticles

scholarly journals Bacteriophage Encapsulation in pH-Responsive Core-Shell Capsules as an Animal Feed Additive

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1131
Author(s):  
Kerry Richards ◽  
Danish J. Malik
Keyword(s):  
Animal Feed ◽  
Feed Additive ◽  
Core Shell ◽  
Ph Responsive ◽  
Zoonotic Infections ◽  
The Core ◽  
Extrusion Processing ◽  
Food Borne ◽  
Wet Heat ◽  
Food Borne Infections

Increasing antibiotic resistance in bacteria that cause zoonotic infections is a major problem for farmers rearing animals for food as well as for consumers who eat the contaminated meat resulting in food-borne infections. Bacteriophages incorporated in animal feed may help reduce carriage and infections in animals including chickens and pigs. There are, however, unmet challenges in protecting phages from processing stresses e.g., during animal feed pelleting operations and during transit of phages through the acidic gastric environment. Core-shell capsules were produced using a concentric nozzle and commercially available encapsulation equipment to fabricate capsules with phages formulated in an oil-in-water microemulsion in the core. pH-responsive capsules released the encapsulated phage cargo within 10–30 min triggered by changes in local environmental pH typically found in the lower gastrointestinal (GI) tract of animals. Acid stability of phages exposed to pH values as low as pH 1 was demonstrated. Encapsulated phages were able to withstand exposure to 95 °C wet heat thermal stress for up to 120 s, conditions typically encountered during feed pellet extrusion processing. Free phages were inactivated within 15 s under these conditions. The present study demonstrates that encapsulation of bacteriophages in core-shell pH-responsive capsules with water-in-oil emulsified phages in the core significantly improves phage viability upon exposure to processing and environmental stresses that require consideration during production of animal feed and application in animals for biocontrol. The results from this study should help guide future development of phage formulations suitable for use in animal feed for animal biocontrol applications.

Core-Shell Pd@Au Nanoplates as Theranostic Agents for In-Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Ct Imaging ◽  
Core Shell ◽  
Theranostic Agents

Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery

2015 ◽  
Vol 51 (14) ◽  
pp. 2999-3002 ◽  
Author(s):  
Yin Wang ◽  
Jianwei Du ◽  
Youxiang Wang ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Drug Delivery ◽  
Acidic Condition ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Aggregate Behavior ◽  
Therapy Effect

A novel type of dual pH-responsive supramolecular prodrug micelles based on pillar[5]arene was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.

Nano-Goethite (α-FeOOH) Magnetic Structure Investigated Using Ising Core-Shell Model: Preliminary Study

2021 ◽  
Vol 1028 ◽  
pp. 193-198
Author(s):  
Budi Adiperdana ◽  
Nadya Larasati Kartika ◽  
Risdiana
Keyword(s):  
High Temperature ◽  
Low Temperature ◽  
Shell Model ◽  
Magnetic Structure ◽  
Paramagnetic State ◽  
Core Shell ◽  
The Core ◽  
Preliminary Study

Ising core-shell model was proposed to reconstruct superparamagnetism hysteresis in nano-goethite (α-FeOOH). Core and shell set as antiferromagnetic and paramagnetic state respectively. Core and shell radius varies until the theoretical hysteresis fit with experiment hysteresis. At low temperature, the hysteresis reconstructed nicely with 55% antiferromagnetic core contribution and 45% paramagnetic shell contribution. At high temperature, the core-shell model show unrealistic result compared to the pure paramagnetic state.

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