scholarly journals Reply to the Letter of Charre et al. “Mis-Genotyping of Some Hepatitis D Virus Genotype 2 and 5 Sequences Using HDVdb”

Viruses ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1278
Author(s):  
Zainab Usman ◽  
Stoyan Velkov ◽  
Ulrike Protzer ◽  
Michael Roggendorf ◽  
Dmitrij Frishman ◽  
...  
Keyword(s):  
Human Error ◽  
Virus Genotype ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
Genotype 2

We thank Charre and colleagues for spotting the mis-annotation of sequences in our database, which was caused by human error [...]

scholarly journals Mis-Genotyping of Some Hepatitis D Virus Genotype 2 and 5 Sequences Using HDVdb

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1066
Author(s):  
Caroline Charre ◽  
Frédéric le Gal ◽  
Paul Dény ◽  
Caroline Scholtès
Keyword(s):  
Liver Fibrosis ◽  
Treatment Response ◽  
Virus Genotype ◽  
Hepatitis D ◽  
Beneficial Use ◽  
Hepatitis D Virus ◽  
Genotype 2 ◽  
Hdv Infection ◽  
Beta Version ◽  
Hdv Genotype

Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong genotyping results. The current HDVdb algorithm should be carefully considered as a “beta-version” and warrants algorithm core corrections, as soon as possible, for an optimal and beneficial use.

scholarly journals Complete Genome Sequence of a Hepatitis D Virus Genotype 1 Strain Isolated in Guangdong, China

2015 ◽  
Vol 3 (6) ◽  
Author(s):  
Baolin Liao ◽  
Weilie Chen ◽  
Qu Ping ◽  
Haiyan Shi ◽  
Haolan He ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Mainland China ◽  
Guangdong Province ◽  
Sequence Information ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hepatitis D ◽  
Hepatitis D Virus

Here, we report the first complete genome sequence of a hepatitis D virus genotype 1 strain, GZ37, isolated in Guangzhou, Guangdong Province, China, in 2014. The sequence information provided here will help us understand the molecular epidemiology of hepatitis D virus and contribute to disease control in mainland China.

scholarly journals Alpha Interferon and Ribavirin Combination Therapy of Chronic Hepatitis D

2005 ◽  
Vol 49 (3) ◽  
pp. 1135-1138 ◽  
Author(s):  
Sabahattin Kaymakoglu ◽  
Cetin Karaca ◽  
Kadir Demir ◽  
Sule Poturoglu ◽  
Ahmet Danalioglu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Combination Therapy ◽  
Alpha Interferon ◽  
Virus Genotype ◽  
Genotype I ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
Biochemical Responses ◽  
End Of Treatment

ABSTRACT The success of alpha interferon (IFN-α) monotherapy for the treatment of chronic hepatitis D is very limited. In this study, the efficacy of IFN-α and ribavirin combination therapy for chronic hepatitis D was investigated. Nineteen patients (15 males; mean age ± standard deviation, 36.8 ± 12.8 years) with chronic hepatitis D who were treated with IFN-α2b (10 million U, three times/week, subcutaneously) and ribavirin (1,000 to 1,200 mg/day, orally) for 24 months were studied. All patients had compensated liver disease (15 were precirrhotic), elevated transaminase levels, and hepatitis D virus RNA positivity at baseline. Genotypic analyses revealed hepatitis D virus genotype I and hepatitis B virus genotype D. All patients completed the 24 months of treatment and at least 6 months (7 to 19 months) of a follow-up period. Biochemical responses were observed in eight patients (42.1%) at the end of treatment and in seven patients (36.8%) at the end of follow-up. Eight patients (42.1%) at the end of treatment and four patients (21%) at the end of follow-up had virological responses. In conclusion, combination treatment of IFN-α and ribavirin for chronic hepatitis D is not able to induce virological responses at a sufficient rate, despite its partial effectiveness in improving biochemical responses, and is not superior to IFN-α monotherapy.

scholarly journals Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela

2001 ◽  
Vol 82 (9) ◽  
pp. 2183-2189 ◽  
Author(s):  
Tatsunori Nakano ◽  
Craig N. Shapiro ◽  
Stephan C. Hadler ◽  
John L. Casey ◽  
Masashi Mizokami ◽  
...  
Keyword(s):  
Hypervariable Region ◽  
Editing Site ◽  
Genome Sequences ◽  
Virus Genotype ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
Genotype Iii ◽  
D Antigen ◽  
Hdv Genotype

The complete genome sequences of hepatitis D virus (HDV) strains isolated from three Yucpa Amerindians in Venezuela were determined and found to be genotype III. Comparison of these three genotype III sequences demonstrated the presence of a hypervariable region containing numerous substitutions, insertions/deletions and a highly conserved region containing the self-cleavage domains, which have been reported previously for genotypes I and II. Amino acid changes within the first 90 amino acids of the hepatitis D antigen (HDAg) were found in the genotype III sequences, while the remainder of the HDAg-coding sequence was conserved. The secondary structure for the RNA-editing site differed between genotypes I and III. It was concluded that the serious delta hepatitis outbreaks characterized epidemiologically in the Yucpa Amerindians were caused by HDV genotype III isolates that were related to HDV genotype III isolates from other regions of South America.

Genetic diversity of hepatitis D virus genotype‐1 in Europe allows classification into subtypes

2019 ◽  
Vol 26 (7) ◽  
pp. 900-910 ◽  
Author(s):  
Hadi Karimzadeh ◽  
Zainab Usman ◽  
Dmitrij Frishman ◽  
Michael Roggendorf
Keyword(s):  
Genetic Diversity ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hepatitis D ◽  
Hepatitis D Virus
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