scholarly journals Swept-Source-Based Chromatic Confocal Microscopy

Sensors ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 7347
Author(s):  
Dawoon Jeong ◽  
Se Jin Park ◽  
Hansol Jang ◽  
Hyunjoo Kim ◽  
Jaesun Kim ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
High Speed ◽  
Imaging System ◽  
Three Dimensional ◽  
Chromatic Aberration ◽  
Cover Glass ◽  
Focal Distance ◽  
Swept Source ◽  
Surface Profiling ◽  
Novel Concept

Chromatic confocal microscopy (CCM) has been intensively developed because it can exhibit effective focal position scanning based on the axial chromatic aberration of broadband light reflected from a target. To improve the imaging speed of three-dimensional (3D) surface profiling, we have proposed the novel concept of swept-source-based CCM (SS-CCM) and investigated the usefulness of the corresponding imaging system. Compared to conventional CCM based on a broadband light source and a spectrometer, a swept-source in the proposed SS-CCM generates light with a narrower linewidth for higher intensity, and a single photodetector employed in the system exhibits a fast and sensitive response by immediately obtaining spectrally encoded depth from a chromatic dispersive lens array. Results of the experiments conducted to test the proposed SS-CCM system indicate that the system exhibits an axial chromatic focal distance range of approximately 360 μm for the 770–820 nm swept wavelength range. Moreover, high-speed surface profiling images of a cover glass and coin were successfully obtained with a short measurement time of 5 ms at a single position.

High-Speed Three-Dimensional Swept Source Optical Coherence Tomography System Based on LabVIEW

2014 ◽  
Vol 41 (7) ◽  
pp. 0704001 ◽  
Author(s):  
王玲 Wang Ling ◽  
朱海龙 Zhu Hailong ◽  
涂沛 Tu Pei ◽  
吴开华 Wu Kaihua
Keyword(s):  
Optical Coherence Tomography ◽  
High Speed ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Swept Source ◽  
Optical Coherence Tomography System ◽  
Tomography System

Three-Dimensional Morphology Study of Capsule in Pseudophakic Eyes with High-Speed Swept-Source Optical Coherence Tomography

2019 ◽  
Vol 44 (6) ◽  
pp. 607-613
Author(s):  
Ding Xixia ◽  
Chang Pingjun ◽  
Zhang Hongfang ◽  
Savini Giacomo ◽  
Huang Jinhai ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Speed ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Swept Source ◽  
Morphology Study

scholarly journals Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics

2020 ◽  
Author(s):  
Denise Valente ◽  
Kari V. Vienola ◽  
Robert J. Zawadzki ◽  
Ravi S. Jonnal
Keyword(s):  
Adaptive Optics ◽  
High Speed ◽  
Imaging System ◽  
Optical Design ◽  
Attractive Potential ◽  
Swept Source ◽  
Full Field ◽  
Common Path ◽  
Cmos Sensor ◽  
Volumetric Images

AbstractA retinal imaging system was designed for full-field (FF) swept-source (SS) optical coherence tomography (OCT) with cellular resolution. The system incorporates a real-time adaptive optics (AO) subsystem and a very high speed CMOS sensor, and is capable of acquiring volumetric images of the retina at rates up to 1 kHz. While digital aberration correction (DAC) is an attractive potential alternative to AO, it has not yet been shown to provide resolution of cones in the fovea, where early detection of functional deficits is most critical. Here we demonstrate that FF-SS-OCT with hardware AO permits resolution of foveal cones, with volume rates adequate to measure light-evoked changes in photoreceptors. With the reference arm blocked, the system can operate as kilohertz AO flood illumination fundus camera with adjustable temporal coherence and is expected to allow measurement of light-evoked changes caused by common path interference in photoreceptor outer segments (OS). In this work, we describe the system’s optical design, characterize its performance, and demonstrate its ability to produce images of the human photoreceptor mosaic.

scholarly journals Improved Enumeration of Weakly Fluorescent CD4+ T-lymphocytes by Confining Cells in a Spinning Sample Cartridge with a Helical Minichannel

Micromachines ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 618
Author(s):  
Subin Kim ◽  
Jakir Hossain Imran ◽  
Mohiuddin Khan Shourav ◽  
Jung Kyung Kim
Keyword(s):  
T Lymphocytes ◽  
High Speed ◽  
Imaging System ◽  
Three Dimensional ◽  
Focal Depth ◽  
Smartphone Application ◽  
Sample Volume ◽  
Cylindrical Sample ◽  
Cd4 Cells ◽  
Cd4 Cell Count

The CD4 (cluster of differentiation 4) counting method is used to measure the number of CD4+ T-lymphocytes per microliter of blood and to evaluate the timing of the initiation of antiretroviral therapy as well as the effectiveness of treatment in patients with human immunodeficiency virus. We developed a three-dimensional helical minichannel-based sample cartridge in which a thread-like microgroove formed in the cylindrical surface and configured a particle-positioning and imaging system equipped with a single DC (direct current) motor that can be controlled by a smartphone application. Confinement and enrichment of CD4 cells within a sharp focal depth along the helical minichannel is accomplished by spinning the cylindrical sample cartridge at high speed before acquiring cell images and thus CD4+ cells with weak fluorescence intensity can be detected even in a channel much deeper than existing two-dimensional flat chambers without an autofocusing module. By detecting more cells in a larger sample volume, the accuracy of the CD4 cell count is improved by a factor of 5.8 with a channel of 500 μm depth and the precision is enhanced by a factor of 1.5 with a coefficient of variation of 2.6%.

scholarly journals 87. Real-Time Three-Dimensional Diagnostic Imaging System Using High-Speed TCT-900S CT Scanner

1990 ◽  
Vol 46 (8) ◽  
pp. 1061
Author(s):  
Tetsurou Hada ◽  
Ichirou Yamagishi ◽  
Yoshiki Hirao ◽  
Hiroshi Aradate ◽  
Hiroyuki Kura ◽  
...  
Keyword(s):  
Diagnostic Imaging ◽  
Real Time ◽  
High Speed ◽  
Imaging System ◽  
Three Dimensional ◽  
Ct Scanner

scholarly journals Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments

2005 ◽  
Vol 13 (26) ◽  
pp. 10652 ◽  
Author(s):  
Yoshiaki Yasuno ◽  
Violeta Dimitrova Madjarova ◽  
Shuichi Makita ◽  
Masahiro Akiba ◽  
Atsushi Morosawa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Speed ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Swept Source
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