scholarly journals Ferrogels Ultrasonography for Biomedical Applications

Sensors ◽  
2019 ◽  
Vol 19 (18) ◽  
pp. 3959 ◽  
Author(s):  
Felix A. Blyakhman ◽  
Sergey Yu Sokolov ◽  
Alexander P. Safronov ◽  
Olga A. Dinislamova ◽  
Tatyana F. Shklyar ◽  
...  
Keyword(s):  
Targeted Drug Delivery ◽  
Biomedical Engineering ◽  
Entire Range ◽  
Biomedical Applications ◽  
Medical Ultrasound ◽  
Acoustic Oscillations ◽  
Echo Signal ◽  
Magnetic Composites ◽  
Targeted Drug ◽  
Cylindrical Samples

Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG samples were prepared in various shapes that are suitable for different characterization techniques. Thin cylindrical samples were used to simulate the case of targeted drug delivery test through blood vessels. Samples of larger size that were in the shape of cylindrical plates were used for the evaluation of the FG applicability as substitutes for damaged structures, such as bone or cartilage tissues. Regardless of the shape of the samples and the conditions of their location, the boundaries of FG were confidently visualized over the entire range of concentrations of MNPs while using medical ultrasound. The amplitude of the reflected echo signal was higher for the higher concentration of MNPs in the gel. This result was not related to the influence of the MNPs on the intensity of the reflected echo signal directly, since the wavelength of the ultrasonic effect used is much larger than the particle size. Qualitative theoretical model for the understanding of the experimental results was proposed while taking into account the concept that at the acoustic oscillations of the hydrogel, the macromolecular net, and water in the gel porous structure experience the viscous Stocks-like interaction.

scholarly journals Formulation and Evaluation of Copper Nanoparticles Loaded Microsponges

2019 ◽  
Vol 11 (04) ◽  
Author(s):  
S. Kothai ◽  
R. Umamaheswari
Keyword(s):  
Copper Nanoparticles ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Hibiscus Rosa Sinensis ◽  
Novel Approach ◽  
Targeted Drug ◽  
Antimicrobial And Antioxidant Activity ◽  
Emulsion Solvent Diffusion Method

Microsponges become imperative in the field of targeted drug delivery and in other biomedical applications. There was a clamant need for designing microsponges incorporating with green synthesised metal nanoparticles rather than the chemical drug in order to reduce the side effects of the drug and thus increasing the effectiveness of nature of the whole material. It provokes us to design this novel approach of loading copper nanoparticles into the microsponges. Here in this work, microsponges based on ethyl cellulose and polyvinyl alcohol were synthesised by Quasi-Emulsion Solvent diffusion method in which copper nanoparticles procured from Hibiscus rosa-sinensis leaf extract was incorporated. The Loaded microsponges were characterised by High Resolution Scanning Electron Microscopy (HR-SEM) and Particle size distribution Analyzer (PSA). The Drug content and Entrapment Efficiency of the microsponges were found out. The antimicrobial and antioxidant activity of the loaded microsponges were evaluated.

scholarly journals Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 656 ◽  
Author(s):  
Shi Su ◽  
Peter M. Kang
Keyword(s):  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Systemic Review ◽  
Advantages And Disadvantages ◽  
Literature Source ◽  
Target Sites ◽  
Different Types ◽  
Bio Imaging ◽  
Targeted Drug ◽  
Careful Design

Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

BIOMEDICAL APPLICATIONS OF MAGNETIC NANOPARTICLES

NANO ◽  
2010 ◽  
Vol 05 (05) ◽  
pp. 245-270 ◽  
Author(s):  
AIGUO WU ◽  
PING OU ◽  
LEYONG ZENG
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Therapeutic Agents ◽  
Short Description ◽  
Resonance Imaging ◽  
Drug Delivery Carrier ◽  
Targeted Drug ◽  
Magnetic Resonance Imaging Mri

In this review, the applications of magnetic nanoparticles in biomedicine are summarized and introduced in three parts. (1) A short description of magnetic nanoparticles is explained. (2) Applications of magnetic nanoparticles in biomedicine are summarized. In biology, new progress of the magnetic separation techniques based on magnetic nanoparticles is discussed. In medicine, the magnetic nanoparticles as therapeutic agents (particularly as a hyperthermia agent, a targeted drug delivery carrier, and a magnetofection agent) as well as contrast agents in magnetic resonance imaging (MRI) are explained in detail. (3) A discussion and remarking conclusion of magnetic nanoparticles in biomedical applications are described. Finally, a perspective of the magnetic nanoparticles in biomedicine in future is also described.

Image Guided Automated Non-Prehensile Magnetic Micromanipulation of Cells

2015 ◽  
Author(s):  
Akash Das ◽  
Ajay D. Thakur ◽  
Atul Thakur
Keyword(s):  
Target Cell ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Cell Manipulation ◽  
Target Cells ◽  
Image Guided ◽  
Targeted Drug ◽  
And Control ◽  
Minimal Adverse Effect ◽  
Ferromagnetic Particles

Biomedical applications like cell manipulation and targeted drug delivery require automated micro-manipulation of biological material. Magnetic micro-manipulation has high actuation speed and minimal adverse effect on cell viability. Ferromagnetic particles, actuated via magnetic field, are used to push a target cell. The process is however cumbersome therefore require automation. This paper reports design, fabrication, and control of an image guided automated non-prehensile magnetic micromanipulation system. The developed system consists of ferromagnetic microspheres (henceforth referred to as microbots) which are actuated via independently controlling currents in four solenoids placed in a quadrupole configuration. We use image based localization for determining the microbot and target cell locations. We developed feedback planner which invokes either of the two maneuvers, namely, push or align to move microbot in order to push the cell towards the goal location. Instead of customize microtools we use simple spherical shaped microbots for pushing target cells.

Novel DNA Aptamers Against CCL21 Protein: Characterization and Biomedical Applications for Targeted Drug Delivery to T Cell-Rich Zones

2018 ◽  
Vol 28 (4) ◽  
pp. 242-251 ◽  
Author(s):  
Louis Chonco ◽  
Gerónimo Fernández ◽  
Rahul Kalhapure ◽  
María J. Hernáiz ◽  
Cecilia García-Oliva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
T Cell ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Protein Characterization ◽  
Dna Aptamers ◽  
Targeted Drug

scholarly journals Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

2021 ◽  
Vol 8 (10) ◽  
pp. 134
Author(s):  
Abdulkader Baki ◽  
Frank Wiekhorst ◽  
Regina Bleul
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Diagnostic Imaging ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Fluid ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Targeted Drug

Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesized iron oxide nanoparticles from bacteria. We compare the technologies and resulting MNPs with conventional synthetic routes. Prominent biomedical applications of the MNPs such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery and magnetic actuation in micro/nanorobots will be presented.

Biomolecular-conjugated nanoparticles for biomedical applications

2016 ◽  
Vol 1 (01) ◽  
Author(s):  
Prachi Goyal ◽  
Kamani Parmar ◽  
Sonika Gupta ◽  
Mukesh Sharma ◽  
M. P. Dobhal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Drug Delivery ◽  
Molecular Motors ◽  
Biomedical Applications ◽  
Biological Functions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
Cellular Compartments

Bimolecular-conjugated nanoparticles (NP) demonstrate unique properties with wide-ranging applications in the diagnosis of infectious diseases as well as application in gene therapy and drug delivery therapies. The unique properties and utility of NP arise from a variety of attributes, including the similar size of nanoparticles and biomolecules. Biological functions depend primarily on units that have nanoscale dimensions, such as viruses, ribosomes, molecular motors and components of the extra cellular matrix. In addition, engineered devices at the nanoscale are small enough to interact directly with sub-cellular compartments and to probe intracellular events. This review focuses on the methods of nanoparticle interaction with different biomolecules such as antibodies, DNA, lipids, and proteins. More specifically, there is discussion about bioconjugation linkage and a summary of potential biomedical applications of bio-conjugated nanoparticles as targeted drug delivery vehicles.

scholarly journals Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests

2015 ◽  
Vol 28 (3) ◽  
pp. 533-538 ◽  
Author(s):  
Christian Peters ◽  
Marcus Hoop ◽  
Salvador Pané ◽  
Bradley J. Nelson ◽  
Christofer Hierold
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Targeted Drug Delivery ◽  
Device Fabrication ◽  
Magnetic Composites ◽  
Targeted Drug

scholarly journals Recent Trends in Biomedical Applications of Nanomaterials

2018 ◽  
Vol 15 (2) ◽  
pp. 235-243 ◽  
Author(s):  
Khalid E. Ibrahim ◽  
Amel O. Bakhiet ◽  
Ayaat Khan ◽  
Haseeb A. Khan
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Disease Diagnosis ◽  
Diagnosis And Treatment ◽  
Biomedical Sciences ◽  
Design And Synthesis ◽  
Recent Trends ◽  
Targeted Drug ◽  
New Generation

In recent years, there have been enormous developments in utilizing the potential of nanotechnology in different fields including biomedical sciences. The most remarkable biomedical applications of nanoparticles (NPs) are in the diagnosis and treatment of various diseases. Functionalization of NPs renders them unique properties so that they can be used as contrast agent for dual or triple modal imaging. The design and synthesis of new generation NPs aiming at targeted drug delivery has revolutionized the safe and effective therapies for complex and difficult to treat diseases. The theranostic NPs possess the dual capabilities for disease diagnosis and treatment. This review highlights the biomedical applications of NPs based on recent reports published in this area of research.

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