Novel DNA Aptamers Against CCL21 Protein: Characterization and Biomedical Applications for Targeted Drug Delivery to T Cell-Rich Zones

2018 ◽  
Vol 28 (4) ◽  
pp. 242-251 ◽  
Author(s):  
Louis Chonco ◽  
Gerónimo Fernández ◽  
Rahul Kalhapure ◽  
María J. Hernáiz ◽  
Cecilia García-Oliva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
T Cell ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Protein Characterization ◽  
Dna Aptamers ◽  
Targeted Drug

scholarly journals Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

2021 ◽  
Vol 8 (10) ◽  
pp. 134
Author(s):  
Abdulkader Baki ◽  
Frank Wiekhorst ◽  
Regina Bleul
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Diagnostic Imaging ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Fluid ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Targeted Drug

Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesized iron oxide nanoparticles from bacteria. We compare the technologies and resulting MNPs with conventional synthetic routes. Prominent biomedical applications of the MNPs such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery and magnetic actuation in micro/nanorobots will be presented.

Biomolecular-conjugated nanoparticles for biomedical applications

2016 ◽  
Vol 1 (01) ◽  
Author(s):  
Prachi Goyal ◽  
Kamani Parmar ◽  
Sonika Gupta ◽  
Mukesh Sharma ◽  
M. P. Dobhal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Drug Delivery ◽  
Molecular Motors ◽  
Biomedical Applications ◽  
Biological Functions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
Cellular Compartments

Bimolecular-conjugated nanoparticles (NP) demonstrate unique properties with wide-ranging applications in the diagnosis of infectious diseases as well as application in gene therapy and drug delivery therapies. The unique properties and utility of NP arise from a variety of attributes, including the similar size of nanoparticles and biomolecules. Biological functions depend primarily on units that have nanoscale dimensions, such as viruses, ribosomes, molecular motors and components of the extra cellular matrix. In addition, engineered devices at the nanoscale are small enough to interact directly with sub-cellular compartments and to probe intracellular events. This review focuses on the methods of nanoparticle interaction with different biomolecules such as antibodies, DNA, lipids, and proteins. More specifically, there is discussion about bioconjugation linkage and a summary of potential biomedical applications of bio-conjugated nanoparticles as targeted drug delivery vehicles.

scholarly journals Recent Trends in Biomedical Applications of Nanomaterials

2018 ◽  
Vol 15 (2) ◽  
pp. 235-243 ◽  
Author(s):  
Khalid E. Ibrahim ◽  
Amel O. Bakhiet ◽  
Ayaat Khan ◽  
Haseeb A. Khan
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Disease Diagnosis ◽  
Diagnosis And Treatment ◽  
Biomedical Sciences ◽  
Design And Synthesis ◽  
Recent Trends ◽  
Targeted Drug ◽  
New Generation

In recent years, there have been enormous developments in utilizing the potential of nanotechnology in different fields including biomedical sciences. The most remarkable biomedical applications of nanoparticles (NPs) are in the diagnosis and treatment of various diseases. Functionalization of NPs renders them unique properties so that they can be used as contrast agent for dual or triple modal imaging. The design and synthesis of new generation NPs aiming at targeted drug delivery has revolutionized the safe and effective therapies for complex and difficult to treat diseases. The theranostic NPs possess the dual capabilities for disease diagnosis and treatment. This review highlights the biomedical applications of NPs based on recent reports published in this area of research.

Engineered Nanoparticles for Prevention against CoVID-19 Infection

2021 ◽  
Vol 1166 ◽  
pp. 41-55
Author(s):  
Raghav Dwivedi ◽  
Meetkamal ◽  
Rajesh Kumar Dwivedi
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Antibacterial Properties ◽  
Therapeutic Agents ◽  
Engineered Nanoparticles ◽  
Diagnostic Measures ◽  
Targeted Drug ◽  
Novel Coronavirus ◽  
Toxicity Effects

The sudden emergence of novel coronavirus CoVID-19 in China during the end of last year and its outburst all around the globe thereafter have raised serious questions about their instant management and diagnostic measures as it is infecting humans around in an exponential manner. The implementation of nanotechnology could perhaps ingenerate the rising distress due to the spread of the disease as the conventional antiviral drugs just control the symptoms. Nanoparticles drug delivery systems are engineered technologies that use nanoparticles for targeted drug delivery and controlled release of therapeutic agents. Nanoparticles based approach can replace the treatment with a more promising one that could meet these challenges. Understanding molecular pathogenesis of CoVID-19 infection is very important to exploit the nanoparticles to fight against it. A lot of nanostructures have been developed with antiviral and antibacterial properties for a variety of drug delivery and biomedical applications. The need of the hour is to exploit nano research to develop effective diagnostics tools, drugs, vaccines to treat and prohibit infection. In this paper an attempt has been made to understand the role and potential of various nanoparticles to inhibit CoVID-19 infection and its toxicity effects.

scholarly journals Biomedical Applications of Targeted Drug Delivery, Nanotheranostic and Nuclear Medicine

2021 ◽  
Author(s):  
Idris Sadiq ◽  
Fatima Sadiq Abubakar ◽  
Hassan Aliyu Hassan
Keyword(s):  
Drug Delivery ◽  
Nuclear Medicine ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Inorganic Nanoparticles ◽  
Radioactive Isotopes ◽  
Target Tissue ◽  
Systemic Distribution ◽  
Novel Method ◽  
Targeted Drug

Background: Convectional methods for drug delivery often faces setbacks due to systemic distribution, short half-life and degradation of therapeutics and therefore reduce concentrations of drug available to target tissue. Nanotheranostic provide a novel method for treating and diagnosing diseases Methodology: collection and review of relevant literatureResult: while nanotheranostic offer advantage of personalized medicine and often combines diagnosis and therapy using single molecular approach, nuclear medicine relies on radioactive isotopes to diagnosed and destroys cancer cells. In both cases, nanocarriers such as lipid-based, polymer-based, drug-conjugate, inorganic nanoparticles are used to deliver drugs/probes/isotopes to target site, generating images and thereafter chemotherapy/radiotherapy begins.Conclusion: Nanotheranostic plays important role in diseases diagnostic, therapy, imaging, monitoring of disease progression / response through the use of nanocarriers. This is made possible through nanoparticles/nanocarriers that delivers drug to the target tissues/cells.

Regulating Motion of Magnetic Capsules in Microfluidic Systems

2010 ◽  
Author(s):  
Hassan Masoud ◽  
Alexander Kilimnik ◽  
Alexander Alexeev
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Viscous Fluids ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Forces ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Magnetic microcapsules are often used as vesicles in targeted drug delivery systems, where focused magnetic field propels the capsules to highly specific locations in tissue. To fully realize this potential it is important to understand the dynamics of magnetically-responsive micrometer sized particles in viscous fluids and the effect of boundaries on particle motion. Furthermore, for practical biomedical applications, it could be useful to create synthetic micrometer-sized vesicles able to perform controlled self-propelled motion. Herein, using computer simulations, we examine the motion of magnetically-responsive synthetic microcapsules that able to crawl along walls in microchannels filled with a viscous fluid. The compliant fluid-filled capsules considered in this study encompass superparamagnetic nanoparticles in their solid shells and, therefore, can be manipulated by alternating magnetic forces.

scholarly journals Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications

2017 ◽  
Vol 53 (8) ◽  
pp. 1405-1408 ◽  
Author(s):  
J. Han ◽  
A. Schmidt ◽  
T. Zhang ◽  
H. Permentier ◽  
G. M. M. Groothuis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Targeted Drug

Supramolecular metallacages hold promise for targeted drug delivery.

Laponite-based Nanomaterials for Biomedical Applications: A Review

2019 ◽  
Vol 25 (4) ◽  
pp. 424-443 ◽  
Author(s):  
Sabya S. Das ◽  
Neelam ◽  
Kashif Hussain ◽  
Sima Singh ◽  
Afzal Hussain ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Adhesion ◽  
Targeted Drug Delivery ◽  
Biomedical Applications ◽  
Biodegradable Materials ◽  
Clay Material ◽  
Research Directions ◽  
Targeted Drug ◽  
Cell Adhesion And Proliferation

Laponite based nanomaterials (LBNMs) are highly diverse regarding their mechanical, chemical, and structural properties, coupled with shape, size, mass, biodegradability and biocompatibility. These ubiquitous properties of LBNMs make them appropriate materials for extensive applications. These have enormous potential for effective and targeted drug delivery comprised of numerous biodegradable materials which results in enhanced bioavailability. Moreover, the clay material has been explored in tissue engineering and bioimaging for the diagnosis and treatment of various diseases. The material has been profoundly explored for minimized toxicity of nanomedicines. The present review compiled relevant and informative data to focus on the interactions of laponite nanoparticles and application in drug delivery, tissue engineering, imaging, cell adhesion and proliferation, and in biosensors. Eventually, concise conclusions are drawn concerning biomedical applications and identification of new promising research directions.

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