scholarly journals Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3782
Author(s):  
Anupama Devi V. K. ◽  
Rohin Shyam ◽  
Arunkumar Palaniappan ◽  
Amit Kumar Jaiswal ◽  
Tae-Hwan Oh ◽  
...  
Keyword(s):  
Composite Materials ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Self Healing ◽  
3D Bioprinting ◽  
Engineering Systems ◽  
Future Perspectives ◽  
Non Covalent Interactions ◽  
Polymeric Hydrogels ◽  
Covalent Interactions

Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘’smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

scholarly journals Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1876
Author(s):  
Lorenzo Marsili ◽  
Michele Dal Bo ◽  
Federico Berti ◽  
Giuseppe Toffoli
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Biological Tissues ◽  
Special Focus ◽  
Thermoresponsive Polymers ◽  
Basic Principles ◽  
Natural Polysaccharide ◽  
Non Covalent Interactions ◽  
Covalent Interactions ◽  
Or Applications

Chitosan is a natural polysaccharide that is considered to be biocompatible, biodegradable and non-toxic. The polymer has been used in drug delivery applications for its positive charge, which allows for adhesion with and recognition of biological tissues via non-covalent interactions. In recent times, chitosan has been used for the preparation of graft copolymers with thermoresponsive polymers such as poly-N-vinylcaprolactam (PNVCL) and poly-N-isopropylamide (PNIPAM), allowing the combination of the biodegradability of the natural polymer with the ability to respond to changes in temperature. Due to the growing interest in the utilization of thermoresponsive polymers in the biological context, it is necessary to increase the knowledge of the key principles of thermoresponsivity in order to obtain comparable results between different studies or applications. In the present review, we provide an overview of the basic principles of thermoresponsivity, as well as a description of the main polysaccharides and thermoresponsive materials, with a special focus on chitosan and poly-N-Vinyl caprolactam (PNVCL) and their biomedical applications.

Construction of triple non-covalent interaction-based ultra-strong self-healing polymeric gels via frontal polymerization

2020 ◽  
Vol 8 (40) ◽  
pp. 14083-14091
Author(s):  
Ji-Dong Liu ◽  
Xiang-Yun Du ◽  
Cai-Feng Wang ◽  
Qing Li ◽  
Su Chen
Keyword(s):  
Frontal Polymerization ◽  
Self Healing ◽  
Smart Window ◽  
Covalent Interaction ◽  
Polymeric Gels ◽  
Non Covalent Interactions ◽  
Covalent Interactions

Robust and self-healing polymeric gels based on triple non-covalent interactions have been constructed for generation of a new self-healing thermoresponsive smart window.

scholarly journals Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries

2021 ◽  
Author(s):  
Oju Jeon ◽  
Yu Bin Lee ◽  
Sang Jin Lee ◽  
Nazilya Guliyeva ◽  
Joanna Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
High Resolution ◽  
Biomedical Applications ◽  
Human Mesenchymal Stem Cells ◽  
Complex Geometries ◽  
Complex Structures ◽  
Self Healing ◽  
3D Bioprinting ◽  
Healing Property

Recently, 3D bioprinting has been explored as a promising technology for biomedical applications with the potential to create complex structures with precise features. Cell encapsulated hydrogels composed of materials such as gelatin, collagen, hyaluronic acid, alginate and polyethylene glycol have been widely used as bioinks for 3D bioprinting. However, since most hydrogel-based bioinks may not allow rapid stabilization immediately after 3D bioprinting, achieving high resolution and fidelity to the intended architecture is a common challenge in 3D bioprinting of hydrogels. In this study, we have utilized shear-thinning and self-healing ionically crosslinked oxidized and methacrylated alginates (OMAs) as a bioink, which can be rapidly gelled by its self-healing property after bioprinting and further stabilized via secondary crosslinking. It was successfully demonstrated that stem cell-laden calcium-crosslinked OMA hydrogels can be bioprinted into complicated 3D tissue structures with both high resolution and fidelity. Additional photocrosslinking enables long-term culture of 3D bioprinted constructs for formation of functional tissue by differentiation of encapsulated human mesenchymal stem cells.

Silver-incorporating peptide and protein supramolecular nanomaterials for biomedical applications

2021 ◽  
Author(s):  
Manzar Abbas ◽  
Atia Atiq ◽  
Ruirui Xing ◽  
Xuehai Yan
Keyword(s):  
Biomedical Applications ◽  
Non Covalent Interactions ◽  
Covalent Interactions

The natural biomolecules of peptides and proteins are able to form elegant metal incorporating supramolecular nanomaterials through multiple weak non-covalent interactions.

Robust Supramolecular Nano-Tunnels Built from Molecular Bricks

2020 ◽  
Author(s):  
Peifa Wei ◽  
Zheng Zheng ◽  
Junyi Gong ◽  
Jun Zhang ◽  
Herman H.-Y. Sung ◽  
...  
Keyword(s):  
Single Crystal ◽  
Organic Molecules ◽  
Co2 Adsorption ◽  
Linear Molecule ◽  
Self Healing ◽  
Pi Stacking ◽  
New Methods ◽  
Hydrogen Bonding Interactions ◽  
Non Covalent Interactions ◽  
Covalent Interactions

Chemists are always seeking new methods to construct porous lattice frameworks using simple motifs as the impetus. Different from the extensively reported frameworks which were stabilized by extended bonding, porous crystals of discrete organic molecules is an emerging area of porous materials with dynamic and flexible conformation, consisting exclusively of non-covalent interactions. Herein we report geometrically simple linear molecule that assemble into a supramolecular nano-tunnel through synergy of anionic trident and multiple intermolecular pi-pi stacking interactions. The nano-tunnel crystal exhibit exceptional chemical stability in concentrated HCl and NaOH aqueous solutions, which is rarely been seen in supramolecular organic frameworks and often related to designed extensive hydrogen bonding interactions. Upon thermal treatment, the formed nano-tunnel crystals go through multistage single-crystal-to-single-crystal phase transformations accompanied by thermosalient effect. Aggregation-induced emission joins with the adaptive pores render the crystals with responsive fluorescent change from blue to yellow and visible self-healing porosity transformation upon being stimulated. Furthermore, the desolvated pores exhibit highly selective CO2 adsorption at ambient temperature. <br>

scholarly journals 3D-printable self-healing and mechanically reinforced hydrogels with host–guest non-covalent interactions integrated into covalently linked networks

2019 ◽  
Vol 6 (4) ◽  
pp. 733-742 ◽  
Author(s):  
Zhifang Wang ◽  
Geng An ◽  
Ye Zhu ◽  
Xuemin Liu ◽  
Yunhua Chen ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Self Healing ◽  
Crosslinked Networks ◽  
Non Covalent Interactions ◽  
Covalently Linked ◽  
Covalent Interactions

Novel 3D-printable hydrogels with host–guest non-covalent interactions and covalently crosslinked networks show robust mechanical strength, self-healing performance and excellent biocompatibility.

The structure–property relationship in LAPONITE® materials: from Wigner glasses to strong self-healing hydrogels formed by non-covalent interactions

Soft Matter ◽  
2019 ◽  
Vol 15 (6) ◽  
pp. 1278-1289 ◽  
Author(s):  
Tiago B. Becher ◽  
Carolyne B. Braga ◽  
Diego L. Bertuzzi ◽  
Miguel D. Ramos ◽  
Ayaz Hassan ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Self Healing ◽  
Structure Property ◽  
Potential Measurement ◽  
Absorbance Spectroscopy ◽  
Structure Property Relationship ◽  
Non Covalent Interactions ◽  
Covalent Interactions ◽  
Scanning Electron

Rheology, SAXS, and dynamic light scattering (DLS) analysis, zeta potential measurement, scanning electron microscopy (SEM), and micro-FTIR and absorbance spectroscopy were used to enlighten the controversial literature about LAPONITE® materials.

Biomedical Applications of Layer-by-Layer Self-Assembly for Cell Encapsulation: Current Status and Future Perspectives

2018 ◽  
Vol 8 (1) ◽  
pp. 1800939 ◽  
Author(s):  
Tengfei Liu ◽  
Ying Wang ◽  
Wen Zhong ◽  
Bingyun Li ◽  
Kibret Mequanint ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Current Status ◽  
Layer By Layer ◽  
Future Perspectives

The role of non-covalent interactions in the self-healing mechanism of disulfide-based polymers

2017 ◽  
Vol 19 (28) ◽  
pp. 18461-18470 ◽  
Author(s):  
Elena Formoso ◽  
José M. Asua ◽  
Jon M. Matxain ◽  
Fernando Ruipérez
Keyword(s):  
The Self ◽  
Self Healing ◽  
Non Covalent Interactions ◽  
Covalent Interactions

We have established a theoretical protocol with the aim of predicting the self-healing capacity of disulfides and related materials.

Hydrogel: Polymeric Smart Material in Drug Delivery

2016 ◽  
Vol 875 ◽  
pp. 45-62 ◽  
Author(s):  
Ranjana Das ◽  
Himadri Sekhar Samanta ◽  
Chiranjib Bhattacharjee
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Skin Grafting ◽  
Living System ◽  
Temperature Modulation ◽  
Self Healing ◽  
Natural Polymers ◽  
Ph Change

A ‘biomaterial’, recognizes some materials for biomedical applications like replacement of living system and wound stressing. ‘Biomaterials’ includes different compounds from diverse origins, like polymers, metals, ceramics and composites. Along with conventional natural polymers (polysaccharides, proteins), synthetic and biodegradable polymers like Polyvinyl alcohol, Polyvinylpyrrolidone, Polyetheleneglycol, Polylactic acid, Polyhydroxy acid are promisingly used in drug delivery, tissue engineering, biomedical sensing, skin grafting and medical adhesives. ‘Hydrogel’ a new generation biodegradable polymer typically used for pharmaceutical and medical purposes. Hydrogels are coined as super absorbent with significant function in health care, especially in wound treatment and protection. Unique characteristics features like enhanced hydrophilicity, biocompatibility, zero-toxicity and biodegradability along with soft and rubbery consistency, low interfacial tension and ‘self-healing’ properties make them compatible with living tissues. Hydrogels have been widely investigated as the carrier for drug delivery systems owing to their unusual characteristics like swelling in aqueous medium, pH and temperature sensitivity, or sensitivity towards other stimuli. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in-vivo environment. In present context, development of ‘in situ’ forming systems for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair are emerging. Among several typical hydrogel synthesis approaches like, solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation, the ‘thermosensitive’ approach is advantageous since it does not require use of any organic solvents, co-polymerization agents and externally applied trigger for gelation. This review presents an overview to the advances in hydrogel based drug delivery system with some reconstructive features in the biomedical applications.

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