Biomedical Applications of Layer-by-Layer Self-Assembly for Cell Encapsulation: Current Status and Future Perspectives

2018 ◽  
Vol 8 (1) ◽  
pp. 1800939 ◽  
Author(s):  
Tengfei Liu ◽  
Ying Wang ◽  
Wen Zhong ◽  
Bingyun Li ◽  
Kibret Mequanint ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Current Status ◽  
Layer By Layer ◽  
Future Perspectives

scholarly journals Layer-by-Layer Self-Assembly Composite Coatings for Improved Corrosion and Wear Resistance of Mg Alloy for Biomedical Applications

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 515
Author(s):  
Tongfang Liu ◽  
Song Rui ◽  
Sheng Li
Keyword(s):  
Wear Resistance ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Composite Coatings ◽  
Covalent Bond ◽  
Mg Alloys ◽  
Mg Alloy ◽  
Layer By Layer ◽  
Corrosion Propagation ◽  
Chemical Linkage

Mg alloys are promising biomedical metal due to their natural degradability, good processability, and favorable mechanical properties. However, the poor corrosion resistance limits their further clinical applications. In this study, the combined strategies of surface chemical treatment and layer-by-layer self-assembly were used to prepare composite coatings on Mg alloys to improve the biocorrosion resistance. Specially, alkalized AZ91 Mg alloy generated chemical linkage with silane via Si–O–Mg covalent bond at the interface. Subsequently, Si–OH group from silane formed a crosslinked silane layer by Si–O–Si network. Further chemical assembly with graphene oxide (GO), lengthened the diffusion pathway of corrosive medium. The chemically assembled composite coatings could firmly bond to Mg alloy substrate, which persistently and effectively acted as compact barriers against corrosion propagation. Improved biocorrosion resistance of AZ91 Mg alloy with self-assembly composite coatings of silane/GO was subsequently confirmed by immersion tests. Besides, the Mg alloy exhibited good wear resistance due to outside layer of GO with a lubricant effect. Cell viability of higher than 75% had also been found for the alloy with self-assembly composite coatings, which showed good cytocompatibility.

Phospholipid-based multifunctional coating via layer-by-layer self-assembly for biomedical applications

2020 ◽  
Vol 116 ◽  
pp. 111237 ◽  
Author(s):  
Peichuang Li ◽  
Xiaojing Li ◽  
Wanhao Cai ◽  
Huiqing Chen ◽  
Hang Chen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Layer By Layer

scholarly journals Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3782
Author(s):  
Anupama Devi V. K. ◽  
Rohin Shyam ◽  
Arunkumar Palaniappan ◽  
Amit Kumar Jaiswal ◽  
Tae-Hwan Oh ◽  
...  
Keyword(s):  
Composite Materials ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Self Healing ◽  
3D Bioprinting ◽  
Engineering Systems ◽  
Future Perspectives ◽  
Non Covalent Interactions ◽  
Polymeric Hydrogels ◽  
Covalent Interactions

Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘’smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

scholarly journals Synthesis and characterization of innovative poly(lactide-co-glycolide)-(poly-l-ornithine/fucoidan) core–shell nanocarriers by layer-by-layer self-assembly

RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32786-32794 ◽  
Author(s):  
Jingqian Fan ◽  
Yuangang Liu ◽  
Shibin Wang ◽  
Yulu Liu ◽  
Siming Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Synthesis And Characterization ◽  
Core Shell ◽  
Layer By Layer

Layer-by-Layer (LbL) self-assembly of nanocarriers has garnered the interest of researchers for a wide variety of biomedical applications.

Self-Assembly Technique for Biomedical Applications

Nano LIFE ◽  
2015 ◽  
Vol 05 (02) ◽  
pp. 1542002 ◽  
Author(s):  
Xiao Gong
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Layer By Layer ◽  
Biomedical Materials ◽  
Biomedical Material ◽  
Potential Applications ◽  
Assembly Technique

Layer-by-layer (LbL) self-assembly has attracted extensive attention for its simplicity and versatility. Self-assembly has many potential applications, among which biomedical applications is especially important because it can be used as a means of generating drug delivery and biomedical materials. Based on this, most recent progress in the field of self-assembly technique for drug delivery and biomedical material applications are summarized in this mini review. The remaining challenges are also mentioned.

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