scholarly journals Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Ocular Therapy

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3649
Author(s):  
Andreea E. Bodoki ◽  
Bogdan-C. Iacob ◽  
Elena Dinte ◽  
Oliviu Vostinaru ◽  
Ovidiu Samoila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Avant Garde ◽  
Internal Structures ◽  
Molecular Imprinting Technology ◽  
Ocular Therapy

Although the human eye is an easily accessible sensory organ, it remains a challenge for drug administration due to the presence of several anatomical and physiological barriers which limit the access of drugs to its internal structures. Molecular imprinting technology may be considered the avant-garde approach in advanced drug delivery applications and, in particular, in ocular therapy. In fact, molecularly imprinted polymers hold the promise to compensate for the current shortcomings of the available arsenal of drug delivery systems intended for ocular therapy. The present manuscript aims to review the recent advances, the current challenges and most importantly to raise awareness on the underexplored potential and future perspectives of molecularly imprinted polymer-based drug delivery systems intended for the treatment of eye diseases.

scholarly journals Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2085 ◽  
Author(s):  
Andreea Elena Bodoki ◽  
Bogdan-Cezar Iacob ◽  
Ede Bodoki
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Drug Delivery Systems ◽  
Value Added ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Severe Toxicity ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cancer Management

Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics’ release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

Synthesis, characterization and in vivo drug delivery study of a biodegradable nano-structured molecularly imprinted polymer based on cross-linker of fructose

Polymer ◽  
2016 ◽  
Vol 97 ◽  
pp. 226-237 ◽  
Author(s):  
Ebadullah Asadi ◽  
Majid Abdouss ◽  
Roger M. Leblanc ◽  
Noushin Ezzati ◽  
James N. Wilson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cross Linker

Molecularly imprinted polymer as drug delivery carrier in alginate dressing

2017 ◽  
Vol 201 ◽  
pp. 46-49 ◽  
Author(s):  
Joanna Kurczewska ◽  
Michał Cegłowski ◽  
Paulina Pecyna ◽  
Magdalena Ratajczak ◽  
Marzena Gajęcka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Drug Delivery Carrier

scholarly journals Rapid and selective recognition of Vibrio parahaemolyticus assisted by perfluorinated alkoxysilane modified molecularly imprinted polymer film

RSC Advances ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 14305-14312 ◽  
Author(s):  
Kaiyue Fu ◽  
Huiwen Zhang ◽  
Yuanyuan Guo ◽  
Juan Li ◽  
Heran Nie ◽  
...  
Keyword(s):  
Polymer Film ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Vibrio Parahaemolyticus ◽  
Selective Recognition ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
High Affinity ◽  
Molecular Imprinting Technology

Molecular imprinting technology offers a means of tailor-made materials with high affinity and selectivity for certain analysts.

Synthesis and Evaluation of Molecularly Imprinted Polymer for Oxalic Acid

2012 ◽  
Vol 622-623 ◽  
pp. 229-235
Author(s):  
Kiran Kumar Tadi ◽  
Ramani V. Motghare
Keyword(s):  
Oxalic Acid ◽  
Molecularly Imprinted Polymer ◽  
Synthetic Receptors ◽  
Binding Parameters ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Convenient Approach ◽  
Ft Ir

Molecular imprinting technology is a convenient approach for preparing synthetic receptors that possesses user defined recognition properties. Oxalic acid imprinted bulk polymer was synthesized by thermal initiated free radical co-polymerization of oxalic acid (template) with two different functional monomers (acrylamide and methacrylic acid) and ethylene glycol dimethacrylate as crosslinker, using acetonitrile (porogen) as solvent. Scanning electron microscopy and FT-IR spectra confirmed the formation of molecularly imprinted polymer (MIP) with acrylamide. The synthesized MIP(ACR)efficiently adsorbed oxalic acid from aqueous solutions. The binding parameters of molecularly imprinted polymer and non-imprinted polymer were compared by Langmuir-Freundlich adsorption (LF) isotherm.

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