Synthesis, characterization and in vivo drug delivery study of a biodegradable nano-structured molecularly imprinted polymer based on cross-linker of fructose

Polymer ◽  
2016 ◽  
Vol 97 ◽  
pp. 226-237 ◽  
Author(s):  
Ebadullah Asadi ◽  
Majid Abdouss ◽  
Roger M. Leblanc ◽  
Noushin Ezzati ◽  
James N. Wilson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cross Linker

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

Molecularly imprinted polymer as drug delivery carrier in alginate dressing

2017 ◽  
Vol 201 ◽  
pp. 46-49 ◽  
Author(s):  
Joanna Kurczewska ◽  
Michał Cegłowski ◽  
Paulina Pecyna ◽  
Magdalena Ratajczak ◽  
Marzena Gajęcka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Drug Delivery Carrier

scholarly journals Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2085 ◽  
Author(s):  
Andreea Elena Bodoki ◽  
Bogdan-Cezar Iacob ◽  
Ede Bodoki
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Drug Delivery Systems ◽  
Value Added ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Severe Toxicity ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cancer Management

Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics’ release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.

Synthesis of a novel cross-linker doubles as a functional monomer for preparing a water compatible molecularly imprinted polymer

2014 ◽  
Vol 6 (23) ◽  
pp. 9483-9489 ◽  
Author(s):  
Xiao Zhang ◽  
Feng Shen ◽  
Zhe Zhang ◽  
Yue Xing ◽  
Xueqin Ren
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Naproxen Sodium ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Bifunctional Monomer ◽  
Cross Linker

A new bifunctional monomer acting as both a cross-linker and a functional monomer was synthesized and applied in the preparation of water-compatible naproxen sodium imprinted polymers.

scholarly journals OPTIMASI PELARUT PENGEKSTRAKSI TEMPLATE MIP (MOLECULAR IMPRINTED POLIMER) FENILBUTAZON DENGAN MONOMER ASAM METAKRILAT

2020 ◽  
Vol 11 (2) ◽  
pp. 161
Author(s):  
Dang Soni ◽  
Shendi Suryana ◽  
Helva Kris Herdianty
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cross Linker

Fenilbutazon merupakan salah satu bahan kimia obat yang banyak ditambahkan ke dalam obat tradisional. Pemakaian bahan kimia obat di dalam sediaan jamu dilarang karena melanggar UU No.23 tahun 1992 tentang Kesehatan dan Undang-Undang No. 8 tahun 1999 tentang Perlindungan Konsumen. Secara umum fenilbutazon dalam sediaan jamu di indentifikasi kandungannya menggunakan metode KLT yang dikombinasi dengan Spektrofotmometri UV, namun metode ini dianggap kurang memiliki sensitifitas yang tinggi. Saat ini dikembangan suatu metode baru yang memiliki sensitifitas lebih tinggi yaitu Molecularly Imprinted Polymer (MIP). MIP adalah suatu metode yang sensitiv dan selektif digunakan untuk mengekstraksi fenilbutazon dari sediaan obat tradisional. Fenilbutazon dari dalam polymer di ekstraksi menggunakan metode soxhletasi. Fenilbutazon akan terekstraksi ke dalam pelarut. Namun terdapat suatu masalah yaitu sulit nya polimer terekstraksi. Maka penelitian ini bertujuan untuk melakukan optimasi pelarut pengekstraksi MIP fenilbutazon. Optimasi ini bertujuan untuk mendapatkan pelarut terbaik dalam mengekstraksi fenilbutazon dari dalam polimer. Penelitian dilakukan dengan tahapan sintesis metode polimerisasi ruah dengan asam metakrilat sebagai monomer, fenilbutazon sebagai template, etilenglikoldimetakrilat sebagai cross-linker, selanjutnya hasil optimasi pelarut yang terbaik dalam mengekstrasi fenilbutazon dari dalam polimer adalah pelarut kloroform-asam asetat dengan perbandingan (99:1) yang dapat mengekstraksi fenilbutazon dari dalam polimer selama 24 jam. Kata Kunci :Molecularly Imprinted, Fenilbutazon, Optimasi

scholarly journals CdTe0.5S0.5/ZnS Quantum Dots Embedded in a Molecularly Imprinted Polymer for the Selective Optosensing of Dopamine

Nanomaterials ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 693 ◽  
Author(s):  
Kiana Khadem-Abbassi ◽  
Hervé Rinnert ◽  
Lavinia Balan ◽  
Zahra Doumandji ◽  
Olivier Joubert ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Ethylene Glycol ◽  
Molecularly Imprinted Polymer ◽  
Limit Of Detection ◽  
Low Cost ◽  
Core Shell ◽  
Selective Detection ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cross Linker

This work describes the preparation of molecularly imprinted polymer (MIP)-modified core/shell CdTe0.5S0.5/ZnS quantum dots (QDs). The QDs@MIP particles were used for the selective and sensitive detection of dopamine (DA). Acrylamide, which is able to form hydrogen bonds with DA, and ethylene glycol dimethylacrylate (EGDMA) as cross-linker were used for the preparation of the MIP. Highly cross-linked polymer particles with sizes up to 1 µm containing the dots were obtained after the polymerization. After the removal of the DA template, MIP-modified QDs (QDs@MIP) exhibit a high photoluminescence (PL) with an intensity similar to that of QDs embedded in the nonimprinted polymer (NIP). A linear PL decrease was observed upon addition of DA to QDs@MIP and the PL response was in the linear ranges from 2.63 µM to 26.30 µM with a limit of detection of 6.6 nM. The PL intensity of QDs@MIP was quenched selectively by DA. The QDs@MIP particles developed in this work are easily prepared and of low cost and are therefore of high interest for the sensitive and selective detection of DA in biological samples.

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